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Clemastine

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Identification
Molecular formula
C21H26ClNO2
CAS number
15686-51-8
IUPAC name
(1-ethylpyrrolidin-2-yl)methyl 2-cyclopentyl-2-hydroxy-2-phenyl-acetate;hydrochloride
State
State

At room temperature, Clemastine hydrochloride is in the solid state. It usually exists as crystalline powder and is stable under normal conditions when stored in a dry, well-sealed container away from light and moisture.

Melting point (Celsius)
214.00
Melting point (Kelvin)
487.15
Boiling point (Celsius)
315.00
Boiling point (Kelvin)
588.15
General information
Molecular weight
459.94g/mol
Molar mass
461.3280g/mol
Density
1.1360g/cm3
Appearence

Clemastine hydrochloride is a white to off-white crystalline powder. It may appear as colorless crystals. In solution form, it is typically clear and without any color.

Comment on solubility

Solubility of (1-ethylpyrrolidin-2-yl)methyl 2-cyclopentyl-2-hydroxy-2-phenyl-acetate;hydrochloride

The solubility of the compound (1-ethylpyrrolidin-2-yl)methyl 2-cyclopentyl-2-hydroxy-2-phenyl-acetate;hydrochloride can be quite intriguing due to its unique structure. This compound, being a hydrochloride salt, typically exhibits higher solubility in polar solvents compared to its base form. Here are some key points regarding its solubility:

  • Polar Solvent Compatibility: The presence of the hydrochloride group suggests good solubility in water and other polar solvents due to ion-dipole interactions.
  • Hydrophobic Regions: The cyclopentyl and phenyl groups contribute to hydrophobic characteristics, which may limit solubility in purely aqueous environments.
  • Temperature Dependence: Solubility can also be influenced by temperature; typically, higher temperatures increase solubility in many cases.
  • pH Sensitivity: The solubility may vary with changes in pH, especially as it undergoes dissociation in different environments.

In conclusion, for practical applications, understanding the solubility behavior of this compound is crucial. As noted, “the solubility of a compound dictates its bioavailability and activity in various formulations”, making studies into its solubility a vital aspect of its chemical profile.

Interesting facts

Interesting Facts About (1-ethylpyrrolidin-2-yl)methyl 2-cyclopentyl-2-hydroxy-2-phenyl-acetate;hydrochloride

(1-ethylpyrrolidin-2-yl)methyl 2-cyclopentyl-2-hydroxy-2-phenyl-acetate;hydrochloride is a fascinating compound with potential applications in various fields. Here are some key points to consider:

  • Pharmaceutical Potential: This compound is of interest in medicinal chemistry for its structural features, which can influence biological activity. Its unique arrangement might contribute to its potential as a therapeutic agent.
  • Structural Diversity: The structure of this compound includes a pyrrolidine ring, which is known for its presence in many important natural products and drugs. Pyrrolidine derivatives often exhibit interesting pharmacological properties.
  • Chirality: Being a compound with stereogenic centers, it can exist in multiple stereoisomeric forms, which might have different activities. This makes studying its stereochemistry important for drug design.
  • Applications in Neuroscience: Given the presence of the pyrrolidinyl group, this compound could potentially interact with neurotransmitter systems, making it a candidate for further investigation in neuropharmacology.

As the field of chemistry continues to evolve, exploring compounds like (1-ethylpyrrolidin-2-yl)methyl 2-cyclopentyl-2-hydroxy-2-phenyl-acetate;hydrochloride opens the door to innovations in drug discovery and development. The intricate chemistry related to such compounds underscores the importance of continued research in this area.

Synonyms
E3XF1ZS4VK
2001-91-4
N-Ethyl-2-pyrrolidylmethyl phenylcyclopentylglycolate hydrochloride
UNII-E3XF1ZS4VK
N-Ethyl-2-pyrrolidylmethylphenylcyclopentyl-glycollate
DTXSID50941994
(1-Ethyl-2-pyrrolidinyl)methyl alpha-cyclopentyl-alpha-hydroxybenzeneacetate hydrochloride
Mandelic acid, .alpha.-cyclopentyl-, (1-ethyl-2-pyrrolidinyl)methyl ester hydrochloride
Benzeneacetic acid, alpha-cyclopentyl-alpha-hydroxy-, (1-ethyl-2-pyrrolidinyl)methyl ester, hydrochloride
N-ethyl-2 pyrrolidylmethyl phenylcyclopentylglycolate hydrochloride
(1-Ethylpyrrolidin-2-yl)methyl cyclopentyl(hydroxy)phenylacetate--hydrogen chloride (1/1)
N-ETHYL-2-PYRROLIDINYLMETHYL-ALPHA-PHENYLCYCLOPENTYL GLYCOLATE HYDROCHLORIDE
BENZENEACETIC ACID, .ALPHA.-CYCLOPENTYL-.ALPHA.-HYDROXY-, (1-ETHYL-2-PYRROLIDINYL)METHYL ESTER, HYDROCHLORIDE (1:1)