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Rivastigmine

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Identification
Molecular formula
C14H22N2O2
CAS number
123441-03-2
IUPAC name
(1-ethylpyrrolidin-2-yl)methyl N-(2,6-dimethylphenyl)carbamate
State
State

At room temperature, Rivastigmine is typically in a solid state, commonly distributed as a powder or in encapsulated form for medicinal use.

Melting point (Celsius)
123.20
Melting point (Kelvin)
396.35
Boiling point (Celsius)
407.90
Boiling point (Kelvin)
681.05
General information
Molecular weight
250.33g/mol
Molar mass
250.3330g/mol
Density
1.0052g/cm3
Appearence

Rivastigmine is typically found as a crystalline solid, either as off-white or a light yellow powder. It is odorless and is often marketed as a tartrate salt to improve its solubility and handling characteristics for pharmaceutical formulations.

Comment on solubility

Solubility of (1-ethylpyrrolidin-2-yl)methyl N-(2,6-dimethylphenyl)carbamate

The solubility of the compound (1-ethylpyrrolidin-2-yl)methyl N-(2,6-dimethylphenyl)carbamate (C14H22N2O2) is influenced by the nature of its chemical structure and functional groups. Here are some key points regarding its solubility:

  • Polarity: The presence of both hydrophilic (carbamate group) and hydrophobic (phenyl and ethyl groups) elements suggests that this compound may exhibit moderate solubility in polar solvents like water.
  • Solvent Compatibility: It is likely to dissolve well in organic solvents such as ethanol, methanol, or acetone, due to its non-polar characteristics from the aromatic and alkyl substituents.
  • Temperature Effects: Solubility can vary significantly with temperature; typically, increased temperatures enhance the solubility of many organic compounds.
  • pH Influence: The solubility may also be affected by the pH of the solution, as changes in ionic form or hydrogen bonding can impact dissolution.

In summary, the solubility of (1-ethylpyrrolidin-2-yl)methyl N-(2,6-dimethylphenyl)carbamate is expected to be moderate, with distinct behaviors in different solvents and conditions. Understanding these solubility characteristics is crucial for practical applications and further experimental designs.

Interesting facts

Interesting Facts about (1-ethylpyrrolidin-2-yl)methyl N-(2,6-dimethylphenyl)carbamate

(1-ethylpyrrolidin-2-yl)methyl N-(2,6-dimethylphenyl)carbamate is a fascinating chemical compound with several notable aspects:

  • Dual Activity: This compound features both a pyrrolidine ring and a carbamate functional group, highlighting its potential for diverse biological activities. Such compounds are often studied for their roles in pharmacology and medicinal chemistry.
  • Potential Applications: Due to its unique structure, this compound may show promise as a lead in drug design. Compounds with ethyl or methyl substitutions often exhibit altered pharmacokinetic properties, suggesting they could lead to better therapeutic agents.
  • Research Opportunities: Scientists are continuously exploring carbamate derivatives for their utility in various fields, particularly in the development of fertilizers, pesticides, and pharmaceuticals. The presence of a bulky dimethylphenyl group can influence the compound's interaction with biological targets.
  • Synthesis Challenges: The synthesis of such complex compounds can be quite challenging. Synthetic chemists often utilize multi-step reactions, and understanding the reactivity of both the pyrrolidine and carbamate moieties requires a deep understanding of organic reaction mechanisms.
  • Structure-Activity Relationship (SAR): Exploring how variations in the structure affect the biological activity is crucial. Researchers often modify the side chains or alter the substituents to improve efficacy and reduce side effects.

As research continues on (1-ethylpyrrolidin-2-yl)methyl N-(2,6-dimethylphenyl)carbamate, it illustrates the intriguing interplay between chemical structure and biological function, presenting exciting avenues for exploration in chemistry and drug development.

Synonyms
(1-Ethyl-2-pyrrolidinyl)methyl 2,6-dimethylcarbanilate
20930-77-2
BRN 1480465
DTXSID10943212
2,6-Dimethylcarbanilic acid (1-ethyl-2-pyrrolidinyl)methyl ester
CARBANILIC ACID, 2,6-DIMETHYL-, (1-ETHYL-2-PYRROLIDINYL)METHYL ESTER
(1-Ethylpyrrolidin-2-yl)methyl hydrogen (2,6-dimethylphenyl)carbonimidate