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Furazolidone

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Identification
Molecular formula
C8H7N3O5S
CAS number
67-45-8
IUPAC name
1-(hydroxymethyl)-3-[(5-nitro-2-furyl)methyleneamino]imidazolidine-2-thione
State
State

Furazolidone is typically a solid at room temperature. As a powder, it is stable and does not undergo phase changes under standard laboratory conditions.

Melting point (Celsius)
259.00
Melting point (Kelvin)
532.15
Boiling point (Celsius)
360.00
Boiling point (Kelvin)
633.15
General information
Molecular weight
225.22g/mol
Molar mass
225.1570g/mol
Density
1.4600g/cm3
Appearence

Furazolidone is a yellow solid. It typically appears as a crystalline powder, which may take on a range of shades from yellow to orange. This coloration is characteristic of many nitrofuran compounds, which absorb light in the visible spectrum.

Comment on solubility

Solubility of 1-(hydroxymethyl)-3-[(5-nitro-2-furyl)methyleneamino]imidazolidine-2-thione

The solubility of 1-(hydroxymethyl)-3-[(5-nitro-2-furyl)methyleneamino]imidazolidine-2-thione is influenced by multiple factors related to its structure and intermolecular interactions. Here are some key points to consider:

  • Polarity: The presence of hydroxymethyl and nitro functional groups suggests that the compound may exhibit polar characteristics, potentially leading to increased solubility in polar solvents like water.
  • Hydrogen Bonding: The hydroxymethyl group can engage in hydrogen bonding, which can enhance solubility in polar media, increasing interactions with solvent molecules.
  • Solvent Compatibility: This compound may show varying solubility in organic solvents. While it could be soluble in polar solvents, it might have limited solubility in nonpolar solvents due to its polar functional groups.

In conclusion, the solubility of this compound is likely to be higher in polar solvents compared to nonpolar solvents, making it suitable for applications in various aqueous environments. However, definitive solubility data should be obtained experimentally to understand its behavior across different conditions.

Interesting facts

Interesting Facts about 1-(Hydroxymethyl)-3-[(5-Nitro-2-Furyl)methyleneamino]imidazolidine-2-thione

This compound is a fascinating example of how organic chemistry can be utilized to create heterocyclic structures with potential biological significance. Here are some interesting facts that highlight its importance:

  • Complex Structure: The compound features a unique fusion of a furan ring and an imidazolidine structure, showcasing the ingenuity involved in organic synthesis.
  • Biological Activity: Compounds like this one are often studied for their potential pharmacological effects. The presence of both nitro and thione functional groups may confer interesting biological properties.
  • Applications: This structure is of interest in medicinal chemistry, particularly in relation to anti-cancer, anti-inflammatory, and anti-microbial research. As scientists explore compounds with these functional groups, they may uncover new therapeutic agents.
  • Innovation in Synthesis: The methods developed to synthesize such compounds can lead to advances in synthetic organic chemistry, providing pathways to create similar derivatives that may possess enhanced activity.
  • Multifunctional Potential: The presence of a hydroxymethyl group along with the imidazolidine core allows for further modifications, which can result in a library of compounds with diversified biological profiles.

In the words of famous chemist Marie Curie, “Nothing in life is to be feared, it is only to be understood.” This principle embodies the journey of understanding such compounds and their potential in promoting human health and scientific innovation.


In summary, 1-(hydroxymethyl)-3-[(5-nitro-2-furyl)methyleneamino]imidazolidine-2-thione represents a complex, biologically relevant molecule that invites further exploration and understanding within the realms of chemistry and medicine.