Skip to main content

Isopropylmethylphenylquinazolinone

ADVERTISEMENT
Identification
Molecular formula
C18H20N2O
CAS number
Not available
IUPAC name
1-isopropyl-7-methyl-4-phenyl-quinazolin-2-one
State
State

At room temperature, Isopropylmethylphenylquinazolinone is in a solid state. It is stable under normal conditions, showing characteristics typical of organic crystalline substances, including a defined melting range which indicates purity.

Melting point (Celsius)
191.00
Melting point (Kelvin)
464.20
Boiling point (Celsius)
545.70
Boiling point (Kelvin)
818.90
General information
Molecular weight
292.37g/mol
Molar mass
292.3690g/mol
Density
1.2154g/cm3
Appearence

The compound appears as a crystalline solid, typically white to off-white in color. Its crystalline nature is indicative of an ordered molecular arrangement, which may lead to the formation of sharp-edged crystal structures.

Comment on solubility

Solubility Characteristics of 1-isopropyl-7-methyl-4-phenyl-quinazolin-2-one

The solubility of 1-isopropyl-7-methyl-4-phenyl-quinazolin-2-one is an intriguing aspect of its chemical behavior. Understanding its solubility is vital for applications in pharmaceuticals and other fields. Key points include:

  • Organic Solvents: This compound is generally more soluble in organic solvents due to its hydrophobic properties, owing to its aromatic and alkyl groups.
  • Aqueous Solubility: It exhibits low solubility in water, which is common for many quinazolinone derivatives, highlighting the importance of solvent choice in formulation.
  • Temperature Influence: Solubility may increase with temperature; hence, higher temperatures could enhance its dissolution in the appropriate solvents.

Moreover, it is essential to consider factors such as:

  • pH levels - Certain pH conditions may favor or hinder solubility.
  • Presence of cosolvents - Mixtures with other solvents can modify solubility behavior.
  • Hydrogen bonding - Interactions with solvent molecules can greatly affect solubility.

In conclusion, while 1-isopropyl-7-methyl-4-phenyl-quinazolin-2-one has limited water solubility, its behavior in organic solvents opens windows for various applications. Further studies may shed light on optimizing its solubility characteristics for diverse uses.

Interesting facts

Interesting Facts about 1-Isopropyl-7-methyl-4-phenyl-quinazolin-2-one

1-Isopropyl-7-methyl-4-phenyl-quinazolin-2-one is a fascinating compound that exhibits a variety of intriguing properties and potential applications. This compound belongs to the quinazolinone family, which has gained significant attention in medicinal chemistry. Here are some interesting insights:

  • Versatile Neuropharmacology: Quinazolinones, including this compound, have been explored for their potential as neuroprotective agents. Research suggests that they may help in addressing neurodegenerative diseases, making them a promising area for therapeutic development.
  • Anticancer Potential: This particular compound has also shown promise in studies aimed at anticancer activity. The structural features of the quinazolinone moiety are believed to enhance its ability to inhibit cancer cell proliferation.
  • Synthesis and Structural Diversity: The synthesis of quinazolinones often involves various strategies, allowing for the introduction of diverse substituents, which can fine-tune their biological activity. The incorporation of an isopropyl group and a phenyl moiety in this compound showcases the versatility in its design.
  • Mechanistic Studies: Ongoing research is focused on understanding the mechanisms through which 1-isopropyl-7-methyl-4-phenyl-quinazolin-2-one exerts its biological effects. Insights into these mechanisms could lead to the development of more effective drugs.
  • Potential Role in Inflammation: Some studies have suggested that quinazolinones may possess anti-inflammatory properties, which could be beneficial for conditions characterized by chronic inflammation.

As researchers continue to investigate the multifaceted characteristics of 1-isopropyl-7-methyl-4-phenyl-quinazolin-2-one, it is clear that this compound holds substantial significance in both academic and pharmaceutical fields. Its unique structure paves the way for numerous applications that could revolutionize therapeutic strategies.

Synonyms
PROQUAZONE
22760-18-5
Arthrex
Proquazonum
Procuazona
42VPJ2980S
DTXSID4021210
RefChem:869875
1-isopropyl-4-phenyl-7-methyl-2-(1H)-quinazoline
DTXCID801210
M01AX13
245-203-7
7-Methyl-1-(1-methylethyl)-4-phenyl-2(1H)-quinazolinone
7-methyl-4-phenyl-1-propan-2-ylquinazolin-2-one
2(1H)-Quinazolinone, 1-isopropyl-7-methyl-4-phenyl-
1-Isopropyl-7-methyl-4-phenyl-2(1H)-quinazolinone
Biarison
Anthrex; Biarison;RU 43-715; SAN 43-715
7-methyl-1-(1-methylethyl)-4-phenylquinazolin-2(1H)-one
Proquazona
7-methyl-4-phenyl-1-(propan-2-yl)-1,2-dihydroquinazolin-2-one
Proquazonum [INN-Latin]
Sandoz 43-715
Proquazona [INN-Spanish]
SaH 43-715
EINECS 245-203-7
BRN 0889725
RU 43715
Proquazone [USAN:INN:BAN]
UNII-42VPJ2980S
Isopropyl-7-methyl-4-phenyl-2(1H)-quinazolinone
1-isopropyl-7-methyl-4-phenylquinazolin-2(1H)-one
Arthrex (TN)
2(1H)-Quinazolinone, 7-methyl-1-(1-methylethyl)-4-phenyl-
PROQUAZONE [MI]
PROQUAZONE [INN]
PROQUAZONE [JAN]
Proquazone (USAN/INN)
PROQUAZONE [USAN]
PROQUAZONE [MART.]
PROQUAZONE [WHO-DD]
Oprea1_335846
SCHEMBL25341
CHEMBL268501
orb1304942
SCHEMBL29508590
CHEBI:135151
BDBM50225112
MFCD00866169
AKOS030227983
DB13649
AS-69800
HY-17491
RU-43715
NS00027255
A10892
D05638
1-isopropyl-7-methyl-4-phenyl-quinazolin-2-one
1-isopropyl-4-phenyl-7-methyl-2[1H]quinazolinone
SR-01000945079
1-Isopropyl-4-phenyl-7-methyl-2(1H)-quinazolinone
7-methyl-1-isopropyl-4-phenyl-2(1H)-quinazolinone
Q7250480
SR-01000945079-1
7-methyl-1-isopropyl-4-phenyl-quinazolin-2(1H)-one
BRD-K54339150-001-01-8
Proquazone; 2(1H)-Quinazolinone, 7-methyl-1-(1-methylethyl)-4-phenyl-; 2(1H)-Quinazolinone, 1-isopropyl-7-methyl-4-phenyl- (8CI); 7-Methyl-1-(1-methylethyl)-4-phenyl-2(1H)-quinazolinone; 1-Isopropyl-4-phenyl-7-methyl-2(1H)-quinazolinone; 1-Isopropyl-7-methyl-4-phenyl