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Etanidazole

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Identification
Molecular formula
C7H11N3O4
CAS number
91917-65-6
IUPAC name
1-methoxy-3-(2-nitroimidazol-1-yl)propan-2-ol
State
State
At room temperature, Etanidazole is a solid, typically encountered as a powder.
Melting point (Celsius)
121.00
Melting point (Kelvin)
394.15
Boiling point (Celsius)
245.50
Boiling point (Kelvin)
518.65
General information
Molecular weight
187.16g/mol
Molar mass
187.1550g/mol
Density
1.5172g/cm3
Appearence
Etanidazole usually appears as a pale yellow to off-white crystalline powder.
Comment on solubility

Solubility of 1-methoxy-3-(2-nitroimidazol-1-yl)propan-2-ol

The solubility of 1-methoxy-3-(2-nitroimidazol-1-yl)propan-2-ol in various solvents is an intriguing aspect worth noting. This compound, due to its unique structure, exhibits varying solubility characteristics that can be pivotal in its application.

Factors Influencing Solubility

Several factors play a role in determining the solubility of this compound:

  • Polarity: The presence of the methoxy group and the nitroimidazole moiety contribute to its polar character, making it more soluble in polar solvents.
  • Hydrogen Bonding: The -OH group can participate in hydrogen bonding, which enhances solubility in solvents capable of such interactions.
  • Molecular Weight: This factor can affect the solubility; larger, heavier molecules often have lower solubility in common solvents compared to lighter counterparts.

Generally, compounds with similar functional groups tend to exhibit comparable solubility behaviors. As quoted, "Like dissolves like," which emphasizes the importance of intermolecular interactions in solvation processes.

Practical Implications

Understanding the solubility profile of 1-methoxy-3-(2-nitroimidazol-1-yl)propan-2-ol is critical for its usage in:

  • Pharmaceutical applications where solubility affects bioavailability.
  • Laboratory conditions for optimal reactivity and stability.
  • Formulation of chemical compounds in various industries.

In conclusion, while specific solubility data for this compound may vary, its structural attributes suggest a propensity for solubility in polar environments, facilitating its potential utility in diverse applications.

Interesting facts

Interesting Facts about 1-Methoxy-3-(2-nitroimidazol-1-yl)propan-2-ol

1-Methoxy-3-(2-nitroimidazol-1-yl)propan-2-ol is a fascinating compound that bridges the realms of chemistry and pharmacology. This compound contains both a methoxy group and a nitroimidazole moiety, contributing to its intriguing biological properties.

Key Features

  • Antimicrobial Activity: The nitroimidazole portion is known for its effectiveness against anaerobic bacteria and protozoa, making this compound a candidate for research in antibiotic development.
  • Mechanism of Action: Nitroimidazoles are thought to work by forming free radicals that damage DNA and inhibit nucleic acid synthesis, leading to cell death in susceptible organisms.
  • Applications in Cancer Therapy: Research has shown that nitroimidazole derivatives may enhance the effectiveness of radiotherapy and chemotherapy by selectively targeting hypoxic tumor cells.
  • Drug Formulation: The methoxy group can improve solubility and stability, making it a valuable feature for pharmaceutical formulations.

Potential for Future Research

The unique structure of 1-methoxy-3-(2-nitroimidazol-1-yl)propan-2-ol makes it a significant subject of interest in medicinal chemistry. Scientists are excited about:

  • Investigating its potential as a therapeutic agent against resistant strains of bacteria.
  • Exploring its efficacy as a radiosensitizer in cancer treatment.
  • Developing derivatives that enhance its pharmacokinetic properties.

"Understanding the chemistry behind such compounds opens doors to novel therapeutic strategies that could change lives."

With its promising biological activity and potential applications, 1-methoxy-3-(2-nitroimidazol-1-yl)propan-2-ol exemplifies the exciting intersection of chemistry and medicine, promising a bright future for research and potential drug development.

Synonyms
Misonidazole
13551-87-6
Misonidazol
Ro 7-0582
Misonidazolum
NSC-261,037
NSC-261037
Ro 07-0582
8FE7LTN8XE
Ro-7-0582
alpha-(Methoxymethyl)-2-nitro-1H-imidazole-1-ethanol
NSC261037
Ro-70582
Ro-07-0582
1H-Imidazole-1-ethanol, alpha-(methoxymethyl)-2-nitro-
Ro 70582
Ro 070582
Ro 7 0582
Ro 07 0582
1-(alpha-methoxymethyl ethanol)-2-Nitroimidazole
236-931-6
1-methoxy-3-(2-nitroimidazol-1-yl)propan-2-ol
1-methoxy-3-(2-nitro-1H-imidazol-1-yl)propan-2-ol
SRI 1354
1-(2-Hydroxy-3-methoxypropyl)-2-nitroimidazole
alpha-(Methoxymethyl)-2-nitroimidazole-1-ethanol
1-(2-NITRO-1-IMIDAZOLYL)-3-METHOXY-2-PROPANOL
MLS003115361
Ro 7-0582; SR 1354
1H-Imidazole-1-ethanol, .alpha.-(methoxymethyl)-2-nitro-
95120-44-8
Misonidazol [INN-Spanish]
Misonidazolum [INN-Latin]
(+-)-Misonidazole
CCRIS 1160
EINECS 236-931-6
UNII-8FE7LTN8XE
SR 1354
BRN 0613655
Misonidazole [USAN:INN:BAN]
1-(2'-hydroxy-3'-methoxypropyl)-2-nitroimidazole
Misonidazole (USAN/INN)
MISONIDAZOLE [INN]
MISONIDAZOLE [USAN]
(2S)-1-methoxy-3-(2-nitro-1H-imidazol-1-yl)propan-2-ol
SCHEMBL51943
MISONIDAZOLE [MART.]
CHEMBL42161
MISONIDAZOLE [WHO-DD]
orb1306161
DTXSID80864420
CHEBI:230671
95120-45-9
NAA55187
VDA12045
VDA12046
AKOS027322846
DB11716
NCGC00241115-01
DA-55501
NCI60_002086
SMR001830939
TS-08213
HY-105061
CS-0024849
NS00053408
D05052
EN300-180393
G89726
.alpha.-(Methoxymethyl)-2-nitroimidazole-1-ethanol
Q6875874
1-methoxy-3-(2-nitro-1H-imidazol-1-yl)-2-propanol
BRD-A16263897-001-06-6
Imidazole-1-ethanol, .alpha.-(methoxymethyl)-2-nitro-