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Metamizole

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Identification
Molecular formula
C13H17N3O2
CAS number
68-89-3
IUPAC name
1-methyl-1-[2-[o-tolyl(phenyl)methoxy]ethyl]guanidine
State
State

At room temperature, metamizole is a solid. It is stable under normal temperature and pressure conditions, making it suitable for pharmaceutical preparations and storage.

Melting point (Celsius)
197.00
Melting point (Kelvin)
470.20
Boiling point (Celsius)
558.50
Boiling point (Kelvin)
831.70
General information
Molecular weight
311.38g/mol
Molar mass
311.3750g/mol
Density
1.1520g/cm3
Appearence

Metamizole is typically encountered as a white or yellowish crystalline powder. It is often provided in pharmaceutical grade, appearing in the form of granules or fine powder. It is generally odorless or may have a slight specific odor.

Comment on solubility

Solubility of 1-methyl-1-[2-[o-tolyl(phenyl)methoxy]ethyl]guanidine

The solubility of 1-methyl-1-[2-[o-tolyl(phenyl)methoxy]ethyl]guanidine can be influenced by various factors such as its molecular structure, temperature, and polarity. Generally, the solubility of organic compounds like this guanidine derivative can be categorized as follows:

  • Polar Solvents: Compounds containing guanidine groups typically exhibit some degree of solubility in polar solvents like water or alcohols due to their ability to form hydrogen bonds.
  • Non-Polar Solvents: Given the presence of aromatic rings in the structure, 1-methyl-1-[2-[o-tolyl(phenyl)methoxy]ethyl]guanidine may also show increased solubility in non-polar solvents such as hexane or toluene.
  • Temperature Effects: Like many organic compounds, the solubility of this guanidine may increase with temperature, which can help overcome intermolecular interactions.

It is essential to note that solubility can also be affected by:

  • pH Levels: Adjustments in pH can significantly impact the ionization state of guanidine, thus affecting solubility.
  • Concentration: High concentrations may lead to precipitation, demonstrating that solubility is not merely a fixed property.

In summary, while 1-methyl-1-[2-[o-tolyl(phenyl)methoxy]ethyl]guanidine is likely to possess moderate solubility characteristics in a variety of solvents, its specific solubility would require empirical testing under defined conditions.

Interesting facts

Interesting Facts about 1-methyl-1-[2-[o-tolyl(phenyl)methoxy]ethyl]guanidine

1-methyl-1-[2-[o-tolyl(phenyl)methoxy]ethyl]guanidine is a fascinating compound with intriguing properties and potential applications in various fields of chemistry and pharmacology. Here are some noteworthy details about this compound:

  • Structure and Function: The unique structure of this compound features a guanidine core, which is known for its basicity and ability to form stable interactions with various biological targets. The presence of the o-tolyl and phenyl groups contributes to its lipophilicity, potentially enhancing its ability to penetrate biological membranes.
  • Biological Activity: Compounds in the guanidine family are often investigated for their pharmacological properties. This specific compound is of interest due to its potential as a neuromodulator or in other therapeutic areas, potentially relating to its ability to interact with neurotransmitter systems.
  • Applications in Research: The structure-activity relationship (SAR) studies of guanidine derivatives like this one shed light on how different substituents can alter biological activity, offering valuable information for drug development.
  • Synthetic Pathways: The synthesis of this compound can be quite intriguing for organic chemists. The methodologies used to obtain this compound often showcase various techniques in organic synthesis, including substitution reactions and functional group manipulations.
  • Cross-disciplinary Relevance: This compound has implications not only in medicinal chemistry but also in materials science. For instance, structural analogs are often explored for their potential use in developing new materials or as catalysts.

In summary, 1-methyl-1-[2-[o-tolyl(phenyl)methoxy]ethyl]guanidine is more than just a chemical formula; it represents a stepping stone into understanding complex biochemical interactions and advancing medicinal chemistry. Its dual interest to both synthetic and applied chemists makes it a valuable compound worthy of further investigation.