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Trimethobenzamide hydrochloride

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Identification
Molecular formula
C24H31ClN2O8
CAS number
138-56-7
IUPAC name
[1-methyl-2-[4-(3,4,5-trimethoxybenzoyl)piperazin-1-ium-1-yl]ethyl] 3,4,5-trimethoxybenzoate;chloride
State
State

Trimethobenzamide hydrochloride is solid at room temperature. It is typically supplied in a crystalline powder form for medicinal or laboratory use.

Melting point (Celsius)
130.00
Melting point (Kelvin)
403.15
Boiling point (Celsius)
290.00
Boiling point (Kelvin)
563.15
General information
Molecular weight
484.98g/mol
Molar mass
484.9510g/mol
Density
1.2507g/cm3
Appearence

Trimethobenzamide hydrochloride appears as a white to off-white crystalline powder. It is typically odorless or may have a slight characteristic odor. It is also hygroscopic, meaning it can absorb moisture from the air.

Comment on solubility

Solubility of 1-methyl-2-[4-(3,4,5-trimethoxybenzoyl)piperazin-1-ium-1-yl]ethyl 3,4,5-trimethoxybenzoate;chloride

The solubility of 1-methyl-2-[4-(3,4,5-trimethoxybenzoyl)piperazin-1-ium-1-yl]ethyl 3,4,5-trimethoxybenzoate;chloride can be influenced by several factors, including its ionic nature and the presence of functional groups. Here are some key points to consider:

  • Ionic Character: The presence of the piperazinium and chloride ions typically enhances solubility in polar solvents.
  • Polyfunctional Groups: The compound's multiple methoxy groups can increase the solubility in various organic solvents due to their electron-donating properties.
  • Hydrophobic and Hydrophilic Balance: The balance between hydrophobic (aromatic rings) and hydrophilic groups affects overall solubility. The trimethoxybenzoyl component adds complexity to the solubility profile.
  • Temperature Effects: Generally, increased temperature can lead to higher solubility; thus, this compound might see enhanced solubility at elevated temperatures.
  • Potential Solvents: Possible solvents could include water, methanol, and ethanol.

An important note is that while the chloride salt form may enhance solubility compared to its free base, practical solubility can vary based on conditions such as pH, ionic strength, and the presence of other solutes.

In conclusion, the solubility of this compound is expected to be favorable in polar solvents due to its ionic and multiple functional group characteristics, although empirical testing is essential for precise quantification.

Interesting facts

Interesting Facts about 1-methyl-2-[4-(3,4,5-trimethoxybenzoyl)piperazin-1-ium-1-yl]ethyl 3,4,5-trimethoxybenzoate;chloride

This unique compound belongs to a class of compounds known for their diverse pharmacological activities. Here are some fascinating aspects to consider:

  • Pharmaceutical Relevance: Compounds featuring piperazine moieties, like this one, are often leveraged in medicinal chemistry for the development of novel pharmaceuticals.
  • Structural Diversity: The presence of multiple methoxy groups provides significant electronic effects, which can influence the compound’s biological activity and its behavior in chemical reactions.
  • Potential Applications: With its complex structure, this compound could be investigated further for applications in areas such as drug design, particularly in targeting neurotransmitter systems.
  • Research Interest: The study of compounds like this often attracts attention in academic and clinical research due to their potential to provide insights into therapeutic mechanisms and to facilitate the discovery of new drugs.

As noted in various studies, such compounds can have remarkable synergistic effects when combined with other therapeutic agents. A common phrase among chemists is, “The whole is greater than the sum of its parts,” which aptly applies to the exploration of multi-functional compounds.

Moreover, with advancements in computational chemistry and molecular modeling techniques, predicting the interactions and biological activities of such complex structures is becoming increasingly feasible, paving the way for more tailored drug development approaches.

In summary, the exploration of 1-methyl-2-[4-(3,4,5-trimethoxybenzoyl)piperazin-1-ium-1-yl]ethyl 3,4,5-trimethoxybenzoate;chloride is rich with potential, reflecting the ongoing advancements within the field of medicinal chemistry and its contributions to improving human health.

Synonyms
NSC172132
991-30-0
Benzoic acid, 3,4,5-trimethoxy-, 1-methyl-2-(4-(3,4,5-trimethoxybenzoyl)-1-piperazinyl)ethyl ester, monohydrochloride
NSC 172132
T-134
Benzoic acid, 3,4,5-trimethoxy-, 1-(4-(3,4,5-trimethoxybenzoyl)piperazzinylmethyl)ethyl ester,hydrochloride
Benzoic acid, 3,4,5-trimethoxy-, ester with alpha-methyl-4-(3,4,5-trimethoxybenzoyl)-1-piperazineethanol,monohydrochloride