Skip to main content

Harmane-3-carboxamide

ADVERTISEMENT
Identification
Molecular formula
C13H11N3O
CAS number
15422-20-3
IUPAC name
1-methyl-2H-pyrido[3,4-b]indole-3-carboxamide
State
State

The compound is typically in a solid state at room temperature. It is stable under standard conditions of storage and handling, but as with most organic compounds, it should be stored in a cool, dry place and kept away from direct light and moisture to maintain its integrity.

Melting point (Celsius)
252.00
Melting point (Kelvin)
525.15
Boiling point (Celsius)
372.00
Boiling point (Kelvin)
645.15
General information
Molecular weight
211.25g/mol
Molar mass
211.2250g/mol
Density
1.3550g/cm3
Appearence

Harmane-3-carboxamide typically appears as a white to light brown solid. The crystalline nature may vary depending on purity and the environment in which it is formed or stored. The compound's appearance is indicative of a class of structures that are often derived from indole alkaloids.

Comment on solubility

Solubility of 1-methyl-2H-pyrido[3,4-b]indole-3-carboxamide

The solubility of 1-methyl-2H-pyrido[3,4-b]indole-3-carboxamide in various solvents plays a crucial role in its potential applications in pharmaceutical and chemical research. Here are some key points regarding its solubility:

  • Solvent Compatibility: The compound typically exhibits varying degrees of solubility in polar and non-polar solvents. It is generally more soluble in organic solvents like DMSO and ethanol, while showing limited solubility in water.
  • pH Dependence: The solubility may be influenced by the pH of the solution. The presence of carboxamide functional groups can lead to changes in solubility based on ionization.
  • Temperature Effects: Increasing temperature often enhances solubility for many compounds. Thus, heating solutions could improve the dissolution rates of 1-methyl-2H-pyrido[3,4-b]indole-3-carboxamide.
  • Formulation Considerations: For practical applications, understanding the solubility profile is essential for formulating effective drug delivery systems or other applications.

In summary, while 1-methyl-2H-pyrido[3,4-b]indole-3-carboxamide may show promising solubility characteristics in specific solvents, it remains essential to assess these properties in the context of the intended use. As is often stated, "The right solvent can make all the difference!"

Interesting facts

Overview of 1-methyl-2H-pyrido[3,4-b]indole-3-carboxamide

1-methyl-2H-pyrido[3,4-b]indole-3-carboxamide, often abbreviated as MPIC, is a fascinating compound in the realm of organic chemistry. It exhibits significant biological activity, making it a compound of interest for medicinal chemistry researchers. Here are some intriguing facts about this compound:

Biological Significance

  • Potential Therapeutic Uses: MPIC has shown promise in studies suggesting potential roles in treating various disorders, particularly those involving neuroinflammation.
  • Effects on the Nervous System: The compound's structure is thought to interact with neurotransmitter receptors, which makes it a candidate for neuropharmacological applications.
  • Natural Occurrence: Some indole derivatives have been found in natural sources, hinting at the possibilities of environmental and ecological roles.

Synthesis Aspects

  • Synthetic Pathways: The synthesis of MPIC typically involves multi-step reactions, showcasing the creativity required in organic synthesis and the importance of understanding reaction mechanisms.
  • Structure-Activity Relationship: Investigating how variations in the chemical structure affect biological activity provides insights into drug design and development.

Research Directions

Ongoing research in this field seeks to:

  • Uncover the complete mechanism of action of MPIC in biological systems.
  • Evaluate its efficacy and safety in clinical trials.
  • Explore analogs of MPIC to enhance therapeutic properties.

In conclusion, 1-methyl-2H-pyrido[3,4-b]indole-3-carboxamide represents a significant compound with great potential in the field of medicinal chemistry. The blend of its intriguing structure, biological relevance, and synthetic challenges makes it an exemplary subject for study in both academic and pharmaceutical research settings.