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1-methyl-3-(4-piperidylmethyl)indole

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Identification
Molecular formula
C15H20N2
CAS number
37148-48-4
IUPAC name
1-methyl-3-(4-piperidylmethyl)indole
State
State

At room temperature, 1-methyl-3-(4-piperidylmethyl)indole is a solid. It maintains a stable form under typical conditions, exhibiting the crystalline features common to organic compounds of similar nature.

Melting point (Celsius)
114.00
Melting point (Kelvin)
387.15
Boiling point (Celsius)
435.00
Boiling point (Kelvin)
708.15
General information
Molecular weight
240.33g/mol
Molar mass
240.3330g/mol
Density
1.1400g/cm3
Appearence

The compound typically appears as a white to off-white crystalline solid. Its general appearance is characterized by small, regular crystals that may slightly vary in shade depending on purity and specific conditions of synthesis.

Comment on solubility

Solubility of 1-methyl-3-(4-piperidylmethyl)indole

The solubility of 1-methyl-3-(4-piperidylmethyl)indole is an intriguing aspect of its chemical behavior. This compound, being a derivative of indole, possesses unique properties that can influence its solubility in various solvents. Here are some key points to consider:

  • Polarity: The polarity of the functional groups present in the molecule affects its ability to dissolve in polar or non-polar solvents.
  • Solvent Compatibility: It generally demonstrates greater solubility in organic solvents such as ethanol, dimethyl sulfoxide (DMSO), and methanol, while exhibiting limited solubility in water.
  • Influencing Factors: Factors such as temperature and pH can significantly impact the solubility behavior of this compound. For instance:
    • Increasing temperature often enhances solubility.
    • A shift in pH can result in ionization of certain groups, thereby affecting solubility.

As a rule of thumb, *“like dissolves like”*, implying that the solubility is favored when the solvent's characteristics are similar to those of the solute. Understanding these solubility trends is crucial for applications in pharmaceuticals and chemical synthesis.

Interesting facts

Interesting Facts about 1-methyl-3-(4-piperidylmethyl)indole

1-methyl-3-(4-piperidylmethyl)indole, often abbreviated as a complex structure, is a fascinating compound that showcases the intricate relationship between indole and piperidine moieties. Below are some noteworthy points regarding its significance:

  • Biological Relevance: This compound is of particular interest in medicinal chemistry, as derivatives of indole are frequently found in various pharmaceutical agents. They exhibit a range of biological activities, including anti-inflammatory, analgesic, and anti-cancer properties.
  • Structural Complexity: The integration of the piperidine ring provides unique steric and electronic properties, potentially influencing the compound's interaction with biological targets. The piperidyl group can enhance solubility and permeability, essential factors in drug design.
  • Research Applications: Given its structural characteristics, this compound is often utilized in neuroscience research to explore its effects on neurotransmitter systems, particularly in relation to serotonin and dopamine.
  • Potential Therapeutic Avenues: Compounds similar to 1-methyl-3-(4-piperidylmethyl)indole have shown promise in treating disorders such as depression and anxiety, highlighting its importance in ongoing pharmacological studies.
  • In-depth Characterization: Chemists are keen on characterizing this compound using various spectroscopic techniques such as NMR and mass spectrometry, elucidating its properties and mechanisms of action.

In summary, 1-methyl-3-(4-piperidylmethyl)indole is not only intriguing from a structural standpoint but also plays a crucial role in current chemical research and therapeutic development. As emphasized by chemists, “the synthesis of such compounds opens new horizons in medicinal chemistry, ultimately leading to advancements in healthcare."

Synonyms
1-methyl-3-(piperidin-4-ylmethyl)-1h-indole
801979-86-2
1-methyl-3-[(piperidin-4-yl)methyl]-1H-indole
DB-276826
EN300-1847677
INDOLE, 1-METHYL-3-(4-PIPERIDYLMETHYL)-