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Niacin

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Identification
Molecular formula
C6H5NO2
CAS number
59-67-6
IUPAC name
1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid
State
State
At room temperature, niacin is typically a solid, appearing as a white or slightly yellowish powder.
Melting point (Celsius)
236.60
Melting point (Kelvin)
509.75
Boiling point (Celsius)
295.00
Boiling point (Kelvin)
568.15
General information
Molecular weight
137.14g/mol
Molar mass
137.1390g/mol
Density
1.4730g/cm3
Appearence

Niacin appears as a white or slightly yellowish crystalline powder. It is odorless or may have a slight odor. The compound may also appear as small needles or as a crystalline powder.

Comment on solubility

Solubility of 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid

1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid is known for its unique solubility characteristics. Its solubility can vary significantly depending on the solvent used. Here are some key points to consider:

  • Polar solvents: This compound shows reasonable solubility in polar solvents such as water and methanol. The presence of the carboxylic acid functional group enhances its ability to interact with polar solvents.
  • Non-polar solvents: In contrast, solubility in non-polar solvents like hexane or toluene is much lower, due to the lack of significant interactions between the compound's structure and non-polar molecules.
  • Temperature effects: As with many organic compounds, the solubility of 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid can increase with rising temperatures, allowing for greater flexibility in applications that require dissolution.
  • Concentration dependence: The equilibrium solubility can also be influenced by the concentration of the solution, which is important to consider in both laboratory and industrial settings.

In summary, the solubility of 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid is primarily determined by the polarity of the solvent and the temperature. This emphasizes the importance of selecting the appropriate solvent system when working with this compound for effective dissolution.

Interesting facts

Interesting Facts about 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid

1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid, often referred to in the realm of organic chemistry, presents a fascinating intersection of structure and function. Here are some noteworthy insights into this compound:

  • Structural Significance: This compound belongs to the pyridine family, characterized by its six-membered aromatic ring system with nitrogen. The unique arrangement of its methyl and carboxylic acid functional groups contributes to its reactivity and potential applications.
  • Biological Relevance: Compounds structurally related to 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid are often studied for their biological activities. They may play a role in various physiological processes, highlighting their potential as pharmaceuticals or biochemical markers.
  • Synthesis Insights: Its synthesis typically involves intricate organic reactions that highlight the beauty of chemical transformations. The compound can be synthesized through several methodologies, including cyclization reactions that form the pyridine structure.
  • Research Potential: The compound's structure suggests various avenues for research, particularly in medicinal chemistry. Scientists are interested in exploring its properties, which may lead to the discovery of new drugs or therapeutic agents.
  • Environmental Considerations: Understanding the environmental impact of such compounds is crucial. As many chemical reactions can yield by-products, research into greener synthetic methods is a growing field.

In summary, 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid offers a rich tapestry of possibilities that enthralls both chemists and students alike. Its intriguing structure and the breadth of applications serve as a reminder of the creativity and innovation inherent in the world of chemistry.

Synonyms
Arecaidine
499-04-7
Methylguvacine
Arecaine
1-Methyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid
N-Methylguvacine
1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid
1,2,5,6-Tetrahydro-1-methylnicotinic acid
NSC 76017
1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarboxylic acid
UNII-0S8YEV0D4O
0S8YEV0D4O
BRN 0112366
NICOTINIC ACID, 1,2,5,6-TETRAHYDRO-1-METHYL-
ARECAIDINE [MI]
NSC-76017
3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl-
DTXSID60198139
5-22-01-00322 (Beilstein Handbook Reference)
1,2,5,6-Tetrahydro-1-methyl-Nicotinic acid
1-methyl-5,6-dihydro-2H-pyridine-3-carboxylic acid
DTXCID40120630
3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl-(9CI)
dnjftxksfamxqf-uhfffaoysa-n
CHEBI:2813
CHEMBL432561
NSC76017
Methylguvacin
SCHEMBL336164
GTPL9487
ALBB-031706
HY-N2368
BDBM50000107
MSK169080
STL565165
AKOS004912635
DA-42310
MS-22815
1ST169080
CS-0022549
Nicotinic acid,2,5,6-tetrahydro-1-methyl-
C15864
Q9159393
3-Pyridinecarboxylic acid,2,5,6-tetrahydro-1-methyl-
1-Methyl-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid
1-Methyl-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid #