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Doxepin hydrochloride

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Identification
Molecular formula
C19H23Cl2N2
CAS number
1229-29-4
IUPAC name
1-methyl-4-[3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propyl]piperazine-1,4-diium;dichloride
State
State

At room temperature, doxepin hydrochloride is a crystalline solid.

Melting point (Celsius)
206.00
Melting point (Kelvin)
479.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
316.32g/mol
Molar mass
316.2210g/mol
Density
1.2003g/cm3
Appearence

Doxepin hydrochloride typically appears as a crystalline solid, either white or almost white in color.

Comment on solubility

Solubility of 1-methyl-4-[3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propyl]piperazine-1,4-diium;dichloride

The compound 1-methyl-4-[3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propyl]piperazine-1,4-diium;dichloride exhibits unique solubility characteristics due to its intricate structure. Understanding the solubility of such complex compounds can be both fascinating and challenging. Here are some key points to consider:

  • Polar vs. Non-Polar: The presence of multiple functional groups influences the overall polarity of the compound, affecting its solubility in water and organic solvents.
  • Solvent Compatibility: It tends to dissolve better in organic solvents like ethanol or dimethyl sulfoxide (DMSO) due to its non-polar tricyclic structure.
  • Water Solubility: As a general rule, compounds with multiple ionic charges can have increased solubility in polar solvents like water; however, in the case of this compound, its overall structure may hinder such solubility.
  • Temperature Influence: Solubility can be affected by temperature changes, where increased temperatures may enhance solubility in specific solvents.

It's crucial to note that the solubility profile of this compound could vary significantly based on factors such as pH and ionic strength of the solution. As always, comprehensive solubility testing is recommended to draw definitive conclusions about its behavior in different environments.

Interesting facts

Interesting Facts about 1-methyl-4-[3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propyl]piperazine-1,4-diium; dichloride

This compound, with a rather complex name, represents an intriguing intersection of organic chemistry and medicinal chemistry. Its structure incorporates various elements that are worth exploring:

  • Complex Molecular Architecture: The presence of a tricyclic structure paired with piperazine showcases the numerous synthetic pathways available in organic synthesis, allowing chemists to explore intricate molecular designs.
  • Potential Biological Activity: Compounds with piperazine moieties are often studied for their pharmacological properties, including anti-anxiety and antipsychotic effects. This suggests a potential role in drug development.
  • Non-linear Conjugation: The tricyclic component linked by the propyl group indicates a system with possible electron delocalization. Such systems can exhibit unique optical and electronic properties that are of great interest in materials science.
  • Divided in Two: Notably, the "diium" in its name suggests a dicationic nature, indicating that the compound carries a positive charge that may enhance its solubility and reactivity in various environments.

This compound serves as an exemplary model of the innovative approaches taken in the synthesis of compounds that bridge structural chemistry and biological application. As scientists investigate its properties, there is much to unlock about its reactivity, interaction with biological systems, and potential application in scientific research.

As one quotation goes: "The beauty of chemistry lies in the ability to create the unthinkable.” This compound is a testament to that creativity in the realm of chemical science.

Synonyms
4467-97-4
5H-Dibenzo(a,d)cycloheptene, 10,11-dihydro-5-(3-(4-methylpiperazinyl)propylidene)-, dihydrochloride