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Harmol

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Identification
Molecular formula
C12H12N2O
CAS number
520-34-3
IUPAC name
1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indol-7-ol
State
State

Harmol is typically found in a solid state at room temperature. It has a crystalline form and is usually manipulated as a powder in laboratory settings.

Melting point (Celsius)
242.00
Melting point (Kelvin)
515.15
Boiling point (Celsius)
311.00
Boiling point (Kelvin)
584.15
General information
Molecular weight
198.24g/mol
Molar mass
198.2270g/mol
Density
1.1880g/cm3
Appearence

Harmol typically appears as a yellowish crystalline solid. It is often described as having a fibrous structure and can form plate-like crystals.

Comment on solubility

Solubility of 1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indol-7-ol

The solubility of a compound is a crucial property that influences its behavior in various chemical and biological environments. For the compound 1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indol-7-ol (C12H12N2O), several factors can impact its solubility:

  • Polarity: With the presence of hydroxyl groups in its structure, this compound possesses some polar characteristics.
  • Intermolecular Interactions: Hydrogen bonding can enhance solubility in polar solvents such as water.
  • Solvent Choice: It is likely to be more soluble in organic solvents like ethanol and methanol compared to non-polar solvents.

As with many indole derivatives, the degree of solubility can significantly vary, potentially making it soluble in moderate to high amounts in specific solvents, yet insoluble or poorly soluble in others. The favorable interaction with water molecules due to its functional groups enriches its solubility profile.

In summary, understanding the solubility of 1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indol-7-ol is essential for its applications in fields ranging from pharmaceuticals to material science.

Interesting facts

Interesting Facts about 1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indol-7-ol

This fascinating compound, 1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indol-7-ol, belongs to the class of pyridoindoles. Pyridoindoles are known for their unique fused ring systems, making them a subject of interest in various fields of chemistry, particularly in drug development.

Applications and Importance

  • Pharmacological Potential: Research indicates that compounds like this can exhibit significant biological activity, including neuroprotective properties.
  • Significance in Organic Synthesis: Pyridoindoles often serve as valuable intermediates in organic synthesis, providing platforms for designing novel therapeutic agents.
  • Natural Sources: Some compounds in this category are derived from natural sources, showcasing the intricate chemistry found in nature.

Structural Features

The structure of this compound showcases an intricate arrangement of nitrogen and carbon atoms that contribute to its chemical properties. Notable features include:

  • A fused indole-pyridine ring system, typical of other biologically active indoles.
  • The presence of hydroxyl (–OH) functionality, which may enhance solubility and biological reactivity.

Research Insights

Ongoing research on 1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indol-7-ol delves into its mechanisms of action, particularly regarding its effects on cellular pathways. Scientists are eager to explore:

  • The potential for this compound to serve as a neuroprotective agent in neurodegenerative diseases.
  • Its visual and cognitive effects, linked to its bioactive properties.

As science continues to unravel the complexities of compounds like 1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indol-7-ol, it becomes evident that there is much more to learn about the potential applications and implications of this intriguing chemical entity.

Synonyms
harmalol
525-57-5
Harmidol
Harmolol
1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indol-7-ol
1-Methyl-4,9-dihydro-3H-beta-carbolin-7-ol
EINECS 208-375-4
UNII-2NQN80556Q
CHEBI:27943
4,9-Dihydro-1-methyl-3H-pyrido(3,4-b)indol-7-ol
2NQN80556Q
3H-Pyrido[3,4-b]indol-7-ol, 4,9-dihydro-1-methyl-
HARMALOL [MI]
NSC 72293
NSC-72293
Harmalol hydrochloride dihydrate
CHEMBL129177
DTXSID50894870
11-Hydroxyharmalan; NSC 72293
3H-Pyrido(3,4-b)indol-7-ol, 4,9-dihydro-1-methyl-
4,9-Dihydro-1-methyl-3H-pyrido[3,4-b]indol-7-ol
1-Methyl-4,9-dihydro-3H-beta-carbolin-7-ol hydrochloride
3,4-DIHYDRO-1-METHYL-9H-PYRIDO(3,4-B)INDOL-7-OL
MLS002153909
1-methyl-4,9-dihydro-3H-pyrido(3,4-b)indol-7-ol
SMR001233258
SR-01000636961
4,9-Dihydro-1-methyl-3H-pyrido[3,4-b]indol-7-ol; 11-Hydroxyharmalan; NSC 72293;
Spectrum_000421
1-methyl-3,4-dihydrobeta-carbolin-7-ol
HARMALINE_met004
Prestwick0_000611
Prestwick1_000611
Prestwick2_000611
Prestwick3_000611
Spectrum2_000556
Spectrum3_000721
Spectrum4_000767
Spectrum5_001307
bmse000988
bmse001010
BSPBio_000542
BSPBio_002242
KBioGR_001154
KBioSS_000901
BIDD:ER0514
DivK1c_000998
SCHEMBL555401
SPBio_000631
SPBio_002761
BPBio1_000598
SCHEMBL15821030
BDBM60980
KBio1_000998
KBio2_000901
KBio2_003469
KBio2_006037
KBio3_001462
DTXSID90975692
cid_16667410
NINDS_000998
DTXCID101324432
NSC72293
TNP00138
BDBM50132101
MFCD00152093
STL565316
AKOS005202957
FH57648
SDCCGMLS-0066705.P001
IDI1_000998
SMP1_000145
3H-Pyrido[3, 4,9-dihydro-1-methyl-
NCGC00017249-01
NCGC00017249-02
NCGC00142520-01
NCI60_013481
TS-09883
1-Methyl-4,9-dihydro-3H-?-carbolin-7-ol
3,4-Dihydro-7-hydroxy-1-methyl-b-carboline
CS-0023033
NS00042837
C06537
A1-00785
SR-01000636961-5
3,4-Dihydro-1-methyl-2H-Pyrido[3,4-b]indol-7-ol
BRD-K14756138-001-01-9
BRD-K14756138-003-02-3
BRD-K14756138-310-03-0
Q15138221
2H-Pyrido[3,4-b]indol-7-ol, 3,4-dihydro-1-methyl-
4,9-Dihydro-1-methyl-3H-pyrido[3,4-b]indol-7-ol, 9CI
1-Methyl-2,3,4,9-tetrahydro-7H-pyrido[3,4-b]indol-7-one
3H-Pyrido(3,4-b)indol-7-ol, 4,9-dihydro-1-methyl-(8CI)
3H-Pyrido(3,4-b)indol-7-ol, 4,9-dihydro-1-methyl-(8CI)(9CI)
1-methyl-2,3,4,9-tetrahydro-beta-carbolin-7-one;hydrate;hydrochloride
1-methyl-2,3,4,9-tetrahydropyrido[3,4-b]indol-7-one;hydrate;hydrochloride
208-375-4