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Metronidazole carbamate

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Identification
Molecular formula
C7H10N4O4
CAS number
65786-07-4
IUPAC name
(1-methyl-5-nitro-imidazol-2-yl)methyl carbamate
State
State

At room temperature, this compound exists as a stable crystalline solid. It is not volatile under normal conditions.

Melting point (Celsius)
145.00
Melting point (Kelvin)
418.20
Boiling point (Celsius)
540.40
Boiling point (Kelvin)
813.50
General information
Molecular weight
218.18g/mol
Molar mass
217.1920g/mol
Density
1.4988g/cm3
Appearence

The compound is typically a crystalline solid and may appear as a pale yellow or slightly beige powder. It may be sensitive to light, causing a deeper coloration when exposed. The texture is generally consistent with that of an organic crystalline powder.

Comment on solubility

Solubility of (1-methyl-5-nitro-imidazol-2-yl)methyl carbamate

The solubility of (1-methyl-5-nitro-imidazol-2-yl)methyl carbamate, with the chemical formula C7H10N4O4, is influenced by several factors including its molecular structure and the presence of functional groups. Factors that typically affect its solubility include:

  • Polarity: The presence of nitro (-NO2) and carbamate (-COO) groups generally increases the polarity of the molecule, which can enhance solubility in polar solvents like water.
  • Hydrogen bonding: The ability of the carbamate group to form hydrogen bonds with water molecules significantly affects solubility.
  • Molecular weight: Smaller molecules tend to be more soluble; thus, the relatively moderate molecular weight of this compound may facilitate good solubility.
  • pH of the solvent: The ionization state of the compound can change with pH, further influencing solubility.

Overall, it is suggested that (1-methyl-5-nitro-imidazol-2-yl)methyl carbamate possesses a moderate solubility in water due to its polar characteristics. As noted in solubility studies, "the efficacy of drug compounds often correlates with their solubility in biological fluids." Therefore, understanding the solubility of this compound is crucial for assessing its potential applications in pharmaceuticals.


In summary, the solubility features of (1-methyl-5-nitro-imidazol-2-yl)methyl carbamate can be crucial for its performance and usability in various fields.

Interesting facts

Interesting Facts about (1-methyl-5-nitro-imidazol-2-yl)methyl carbamate

(1-methyl-5-nitro-imidazol-2-yl)methyl carbamate is a fascinating compound with several notable attributes.
It belongs to the class of imidazole derivatives, which are particularly significant in medicinal chemistry due to their biological activity.

Applications in Medicine

This compound, like other derivatives of imidazole, has been investigated for various pharmacological properties. Some potential uses include:

  • Antimicrobial Activity: Compounds containing imidazole rings exhibit strong antifungal and antibacterial properties.
  • Anti-inflammatory Effects: Research suggests that imidazole derivatives may help reduce inflammation.
  • Applications in Cancer Research: Some studies are exploring the efficacy of imidazole derivatives in targeting cancer cells.

Structural Significance

The structure of this compound is particularly interesting:

  • The presence of the nitro group enhances its reactivity and biological potential.
  • The imidazole ring itself contributes to unique interactions with biological molecules, making it a focus in drug design.

Quote from Research

As noted in various studies, "The versatility of imidazole derivatives in medicinal chemistry cannot be overstated; they often serve as a core structure for drug discovery." This highlights the importance of compounds like (1-methyl-5-nitro-imidazol-2-yl)methyl carbamate.

Environmental Considerations

Furthermore, the environmental impact of such compounds is under scrutiny. As scientists delve deeper into their chemical behavior, understanding their stability and degradation pathways in ecosystems becomes crucial.

In conclusion, (1-methyl-5-nitro-imidazol-2-yl)methyl carbamate is not just a chemical formula; it's a gateway to exploring innovative solutions in medicine and environmental science.

Synonyms
ronidazole
7681-76-7
Ronidazol
Ridzol
Ridzol P
Ridazole
Dugro
(1-Methyl-5-nitroimidazol-2-yl)methyl carbamate
(1-Methyl-5-nitro-1H-imidazol-2-yl)methyl carbamate
Ronidazolum
1H-Imidazole-2-methanol, 1-methyl-5-nitro-, carbamate (ester)
Ronidazol-pharmachim
Ronidazol [INN-Spanish]
Ronidazolum [INN-Latin]
1-Methyl-5-nitroimidazole-2-methanol carbamate ester
EINECS 231-675-1
NSC-757865
BRN 0886221
DTXSID6045400
UNII-E01R4M1063
AI3-27430
1-Methyl-5-nitro-1H-imidazole-2-methanol carbamate ester
E01R4M1063
1-Methyl-5-nitro-1H-imidazole-2-methanol 2-Carbamate
MLS000028665
Carbamidsaeure-((1-methyl-5-nitroimidazol-2-yl)methyl)ester
DTXCID4025400
CHEBI:141154
5-23-10-00553 (Beilstein Handbook Reference)
Ronidazole (USAN)
NSC 757865
NCGC00016685-05
SMR000058887
CAS-7681-76-7
Ronidazol (INN-Spanish)
RONIDAZOLE [USAN]
Ronidazolum (INN-Latin)
RONIDAZOLE (MART.)
RONIDAZOLE [MART.]
carbamic acid (1-methyl-5-nitro-2-imidazolyl)methyl ester
Ronidazole (1000 ug/mL in Methanol)
MCMN
Ronidazol-pharmachim [Bulgarian]
SR-01000000287
Ronidazole; (1-Methyl-5-nitro-imidazol-2-yl)methyl carbamate
Ronidazole [USAN:INN:BAN]
(1-methyl-5-nitro-imidazol-2-yl)methyl carbamate
MFCD00133801
Ronidazole (Standard)
Spectrum_001147
RONIDAZOLE [MI]
RONIDAZOLE [INN]
Opera_ID_1383
Prestwick0_001115
Prestwick1_001115
Prestwick2_001115
Prestwick3_001115
Spectrum2_001037
Spectrum3_001461
Spectrum4_000450
Spectrum5_001151
1-Methyl-2-carbamoyloxymethyl-5-nitroimidazole
1-Methyl-2-(carbamoyloxymethyl)-5-nitroimidazole
BSPBio_001250
BSPBio_002981
KBioGR_000840
KBioSS_001627
DivK1c_000927
SCHEMBL635714
SPECTRUM1501154
SPBio_001253
SPBio_003115
Ronidazole, analytical standard
BPBio1_001375
CHEMBL290299
CHEBI:94804
HMS502O09
HY-B0565R
KBio1_000927
KBio2_001627
KBio2_004195
KBio2_006763
KBio3_002481
NINDS_000927
HMS1571O12
HMS1921L13
HMS2092H21
HMS2098O12
HMS2236G04
HMS3370P07
HMS3652I06
HMS3715O12
Pharmakon1600-01501154
HY-B0565
Tox21_110560
Tox21_303404
CCG-40249
NSC757865
AKOS016014971
Tox21_110560_1
FR27752
IDI1_000927
NCGC00016685-01
NCGC00016685-02
NCGC00016685-03
NCGC00016685-04
NCGC00016685-06
NCGC00016685-07
NCGC00016685-11
NCGC00021749-03
NCGC00021749-04
NCGC00021749-05
NCGC00257484-01
AS-10175
DA-57510
SBI-0051664.P002
AB00052226
NS00000699
S4062
SW197236-3
D05752
AB00052226_14
AB00052226_15
Imidazole-2-methanol, 1-methyl-5-nitro-, carbamate
Q7365706
SR-01000000287-2
SR-01000000287-3
BRD-K94266545-001-15-9
BRD-K94266545-001-23-3
BRD-K94266545-001-24-1
(1-Methyl-5-nitro-1H-imidazol-2-yl)methyl carbamate #
1H-Imidazole-2-methanol, 1-methyl-5-nitro-, carbamate
1-methyl-5-nitro-1H-imidazole-2-methanol carbamate ester
231-675-1
Ronidazole;(1-Methyl-5-nitroimidazol-2-yl)methyl carbamate;1-Methyl-2-carbamoyloxymethyl-5-nitroimidazole