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Brotizolam

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Identification
Molecular formula
C15H15BrN2OS
CAS number
57801-81-7
IUPAC name
1-methyl-5-phenyl-2,3-dihydro-1,4-benzodiazepin-7-amine
State
State

At room temperature, Brotizolam is in a solid state, typically as a crystalline powder.

Melting point (Celsius)
163.00
Melting point (Kelvin)
436.15
Boiling point (Celsius)
343.20
Boiling point (Kelvin)
616.35
General information
Molecular weight
343.21g/mol
Molar mass
343.2110g/mol
Density
1.2123g/cm3
Appearence

Brotizolam is typically a white or off-white crystalline powder.

Comment on solubility

Solubility of 1-methyl-5-phenyl-2,3-dihydro-1,4-benzodiazepin-7-amine

The solubility of 1-methyl-5-phenyl-2,3-dihydro-1,4-benzodiazepin-7-amine in various solvents can give valuable insights into its chemical behavior and potential applications. Generally, the solubility of this compound can be influenced by several factors:

  • Polarity: The presence of polar and nonpolar functional groups in the structure affects solubility. Compounds that are polar tend to dissolve better in polar solvents such as water, while nonpolar compounds find better solubility in organic solvents like hexane.
  • Temperature: As with many compounds, solubility may increase with temperature. Higher temperatures can provide the additional energy needed to overcome intermolecular forces.
  • pH Levels: For amine compounds, changes in pH can significantly influence solubility. Basic conditions can lead to enhanced solubility of cationic forms, while acidic environments might form insoluble salts.

In practice, this compound exhibits moderate solubility characteristics, typically demonstrating better solubility in organic solvents compared to aqueous solutions. As stated, "the versatility of chemical compounds often allows for improved solubility under specific conditions." Thus, understanding the solubility behavior of 1-methyl-5-phenyl-2,3-dihydro-1,4-benzodiazepin-7-amine is crucial for its applications in pharmaceuticals and synthesis, enabling effective formulation in drug development processes.

Interesting facts

Interesting Facts about 1-methyl-5-phenyl-2,3-dihydro-1,4-benzodiazepin-7-amine

This compound belongs to the benzodiazepine family, renowned for their pharmaceutical significance. Benzodiazepines are widely recognized for their effects as anxiolytics, sedatives, and muscle relaxants. Here are some intriguing details about 1-methyl-5-phenyl-2,3-dihydro-1,4-benzodiazepin-7-amine:

  • Structure and Variability: The presence of a methyl group and a phenyl ring in its structure contributes to the unique properties of this compound among benzodiazepines.
  • Biological Activity: Compounds in the benzodiazepine class generally exhibit a range of biological activities, including modulation of the GABA receptors, which play a crucial role in inhibitory neurotransmission in the nervous system.
  • Medical Applications: While specific applications of this compound may not be widely studied, benzodiazepines are commonly prescribed for anxiety disorders, sleep disturbances, and seizure management.
  • Research Potential: The unique structure of 1-methyl-5-phenyl-2,3-dihydro-1,4-benzodiazepin-7-amine could lead researchers to explore its potential derivatives, designing new analogs with improved efficacy or reduced side effects.
  • Historical Significance: The discovery of benzodiazepines represents a significant milestone in pharmacology, leading to safer alternatives to barbiturates for treating anxiety-related conditions.

As we continue to delve into the properties and applications of compounds like 1-methyl-5-phenyl-2,3-dihydro-1,4-benzodiazepin-7-amine, the ongoing research in this field promises to reveal further therapeutic potentials and important insights into neurochemistry.

Synonyms
ME7AGD1ROQ
RO-5-4964 free base
BRN 0750422
UNII-ME7AGD1ROQ
1H-1,4-BENZODIAZEPINE, 2,3-DIHYDRO-7-AMINO-1-METHYL-5-PHENYL-
2,3-Dihydro-7-amino-1-methyl-5-phenyl-1H-1,4-benzodiazepine
DTXSID70183177
5-25-11-00389 (Beilstein Handbook Reference)
1H-1,4-Benzodiazepin-7-amine, 2,3-dihydro-1-methyl-5-phenyl-
2,3-DIHYDRO-1-METHYL-5-PHENYL-1H-1,4-BENZODIAZEPIN-7-AMINE
DTXCID80105668
2898-06-8