Skip to main content

Flurazepam

ADVERTISEMENT
Identification
Molecular formula
C21H23ClF2N4O1
CAS number
17617-23-1
IUPAC name
1-methyl-5-phenyl-7-(trifluoromethyl)-1,5-benzodiazepine-2,4-dione
State
State

Flurazepam is typically a solid at room temperature.

Melting point (Celsius)
169.00
Melting point (Kelvin)
442.15
Boiling point (Celsius)
352.20
Boiling point (Kelvin)
625.35
General information
Molecular weight
368.76g/mol
Molar mass
368.7550g/mol
Density
1.4935g/cm3
Appearence

Flurazepam typically appears as a white or almost white crystalline powder. It can also sometimes appear in the form of crystals. This compound is odourless.

Comment on solubility

Solubility of 1-methyl-5-phenyl-7-(trifluoromethyl)-1,5-benzodiazepine-2,4-dione

The solubility of 1-methyl-5-phenyl-7-(trifluoromethyl)-1,5-benzodiazepine-2,4-dione can be quite complex due to its intricate molecular structure. Here are some important points to consider:

  • Polarity: With the presence of the trifluoromethyl group, the compound exhibits notable polar characteristics.
  • Solvent Interaction: It is likely to show varying solubility in different solvents:
    • High solubility in polar solvents such as methanol and ethanol.
    • Low solubility in non-polar solvents like hexane.
  • Temperature Dependence: The solubility might increase with temperature, which is a common behavior for many organic compounds.
  • pH Influence: The solubility could also be influenced by the pH of the solution.

In summary, understanding the solubility of this compound is essential for its applications, particularly in pharmaceuticals where solubility can dictate bioavailability. Overall, it is a compound that demonstrates significant solubility behavior, making it a subject of interest in both synthetic and analytical chemistry.

Interesting facts

Interesting Facts about 1-Methyl-5-phenyl-7-(trifluoromethyl)-1,5-benzodiazepine-2,4-dione

The compound 1-methyl-5-phenyl-7-(trifluoromethyl)-1,5-benzodiazepine-2,4-dione belongs to a class of compounds known as benzodiazepines, which are significant in medicinal chemistry. Here are some key insights:

  • Pharmacological Activity: Benzodiazepines are primarily known for their psychoactive effects. They act as anxiolytics, sedatives, and muscle relaxants, making them important in treating anxiety, insomnia, and seizure disorders.
  • Structure-Activity Relationship: The unique structural features of this particular compound, such as the trifluoromethyl group, can greatly influence its biological activity and potency. The presence of electron-withdrawing groups often enhances the compound's lipophilicity, thus affecting its absorption and distribution.
  • Research Applications: Compounds like this one are often used in research to study their effects on the central nervous system. They can serve as valuable references for developing new therapeutic agents with reduced side effects.
  • Potential Side Effects: While benzodiazepines are effective, they are also associated with a risk of dependence and withdrawal symptoms. Understanding the pharmacokinetics and pharmacodynamics of this compound could lead to safer alternatives.
  • Future Prospects: As research progresses, modifications to the structure of benzodiazepines continue to be explored. The aim is to create derivatives that retain therapeutic benefits while minimizing adverse effects. Scientists are optimistic about the potential of such derivatives in enhancing mental health treatments.

As a student of chemistry, exploring the interactions and applications of compounds like 1-methyl-5-phenyl-7-(trifluoromethyl)-1,5-benzodiazepine-2,4-dione reveals the intricate relationship between molecular structure and function. Studying such compounds is essential for innovations in pharmaceutical chemistry.

Synonyms
Triflubazam
22365-40-8
Triflubazamum
WE352
ORF-8063
WE-352
1H-1,5-Benzodiazepine-2,4(3H,5H)-dione, 1-methyl-5-phenyl-7-(trifluoromethyl)-
80D8H0388T
DTXSID40176899
1-methyl-5-phenyl-7-trifluoromethyl-(1H)-1,5-benzodiazepine-2,4-(3H,5H)dione
RefChem:933399
DTXCID2099390
1-methyl-5-phenyl-7-(trifluoromethyl)-1,5-benzodiazepine-2,4-dione
Triflubazam [USAN:INN]
Triflubazamum [INN-Latin]
ORF 8063
WE 352
BRN 0765367
UNII-80D8H0388T
1-Methyl-5-phenyl-7-(trifluoromethyl)-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
TRIFLUBAZAM [INN]
Triflubazam (USAN/INN)
TRIFLUBAZAM [USAN]
5-24-08-00072 (Beilstein Handbook Reference)
SCHEMBL635822
orb1745204
CHEMBL2107285
1-Methyl-5-phenyl-7-(trifluoromethyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
TS-09485
HY-101553
CS-0021697
NS00121057
D06231
Q7841496