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1-Methyl-6-phenyl-1,2,3,4-tetrahydroisoquinolinium chloride

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Identification
Molecular formula
C16H20ClN
CAS number
39691-78-8
IUPAC name
1-methyl-6-phenyl-1,2,3,4-tetrahydroisoquinolin-2-ium;chloride
State
State

At room temperature, 1-methyl-6-phenyl-1,2,3,4-tetrahydroisoquinolinium chloride is typically found in a solid state. The compound is stable under standard conditions.

Melting point (Celsius)
180.00
Melting point (Kelvin)
453.00
Boiling point (Celsius)
275.00
Boiling point (Kelvin)
548.00
General information
Molecular weight
275.78g/mol
Molar mass
275.7780g/mol
Density
1.1200g/cm3
Appearence

1-Methyl-6-phenyl-1,2,3,4-tetrahydroisoquinolinium chloride typically appears as a crystalline solid. Its specific color and clarity can vary depending on its purity and form of crystallization.

Comment on solubility

Solubility of 1-methyl-6-phenyl-1,2,3,4-tetrahydroisoquinolin-2-ium; chloride

The solubility of 1-methyl-6-phenyl-1,2,3,4-tetrahydroisoquinolin-2-ium; chloride can be influenced by several factors, including its ionic nature and the chemical environment. Generally, quaternary ammonium salts like this compound tend to exhibit a high degree of solubility in polar solvents. Here are a few key points to consider:

  • Solvent Polarity: The compound is likely to be soluble in water due to its ionic character. Ionic compounds often dissolve well in polar solvents.
  • Temperature Effects: Increased temperature can enhance the solubility of many compounds, including 1-methyl-6-phenyl-1,2,3,4-tetrahydroisoquinolin-2-ium; chloride.
  • pH Influence: At different pH levels, the solubility can vary due to potential protonation or deprotonation of the nitrogen centers.
  • Presence of Other Ions: The solubility may also be affected by the presence of other ions in the solution, which could lead to competition for solvation.

Because of these factors, it is essential to empirically determine the solubility under specific experimental conditions. Understanding the solubility characteristics of this compound is crucial for applications in various areas, including medicinal chemistry and drug formulation.

Interesting facts

Interesting Facts About 1-methyl-6-phenyl-1,2,3,4-tetrahydroisoquinolin-2-ium;chloride

This fascinating compound is a member of the tetrahydroisoquinoline family, which is renowned for its structural complexity and versatility in organic chemistry. The unique structure of 1-methyl-6-phenyl-1,2,3,4-tetrahydroisoquinolin-2-ium includes a methyl group and a phenyl group attached to the tetrahydroisoquinoline skeleton, which contributes to its distinctive properties and possible reactivity.

Key Highlights:

  • Biological Importance: Compounds like this are often investigated for their potential biological activities, including effects on the central nervous system. They can act as precursors to neuroactive substances.
  • Synthetic Utility: The synthesis of tetrahydroisoquinoline derivatives is a focus area in medicinal chemistry, as they serve as scaffolds for drug development, particularly in treating neurodegenerative diseases.
  • Research Potential: Current research investigates the implications of such compounds in pharmacology and toxicology, considering their interactions at the molecular level.

Moreover, the presence of the chloride ion plays a crucial role in enhancing the solubility and stability of the compound in various solvents, making it a valuable subject for further studies in various formulations and mechanisms of action.

Quote from Chemistry Literature:
"As synthetic chemists continue to explore the nuances of complex molecules, the dual reactivity showcased by tetrahydroisoquinolines opens new avenues for innovation and discovery in pharmaceutical sciences."

This compound, therefore, not only captivates scientists with its intricate structure but also holds promise for future advancements in both theoretical and applied chemistry, particularly in the development of therapeutic agents.

Synonyms
24464-12-8
DTXSID50947350
1-Methyl-6-phenyl-1,2,3,4-tetrahydroisoquinoline--hydrogen chloride (1/1)
RefChem:1055827
DTXCID401375610
1-Methyl-6-phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride
ISOQUINOLINE, 1,2,3,4-TETRAHYDRO-1-METHYL-6-PHENYL-, HYDROCHLORIDE