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1-Methyl-6-phenyl-1,2,3,4-tetrahydroisoquinoline

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Identification
Molecular formula
C16H17N
CAS number
1798-66-9
IUPAC name
1-methyl-6-phenyl-1,2,3,4-tetrahydroisoquinoline
State
State

At room temperature, 1-methyl-6-phenyl-1,2,3,4-tetrahydroisoquinoline is typically a solid. It is important to store the compound in a cool, dry place to maintain its stability and prevent any potential decomposition.

Melting point (Celsius)
85.00
Melting point (Kelvin)
358.20
Boiling point (Celsius)
337.20
Boiling point (Kelvin)
610.30
General information
Molecular weight
221.32g/mol
Molar mass
221.3000g/mol
Density
1.0791g/cm3
Appearence

1-Methyl-6-phenyl-1,2,3,4-tetrahydroisoquinoline is typically found as a white to light yellow powder or crystalline solid. The exact appearance can vary slightly based on purity and specific form, but it usually maintains a consistent form at room temperature when properly synthesized.

Comment on solubility

Solubility of 1-methyl-6-phenyl-1,2,3,4-tetrahydroisoquinoline

The solubility of 1-methyl-6-phenyl-1,2,3,4-tetrahydroisoquinoline can be quite intriguing, as it presents unique characteristics inherent to its molecular structure. This compound is primarily known to be:

  • Practically insoluble in water: The hydrophobic nature of the aromatic phenyl group coupled with the tetrahydroisoquinoline framework significantly limits its interaction with water molecules.
  • Soluble in organic solvents: It demonstrates a higher solubility in non-polar solvents such as hexane, dichloromethane, and ethanol, making these solvents more favorable for dissolution.
  • Temperature-sensitive: Increased temperatures may enhance solubility in organic solvents, highlighting the potential for varying solubility profiles under different conditions.

In essence, the compound exhibits solubility behavior that can be summarized as follows:

  1. Low solubility in polar solvents (e.g., water).
  2. Better solubility in non-polar solvents.
  3. Variable solubility influenced by temperature.

In many practical applications, understanding these solubility traits is essential, especially in fields such as medicinal chemistry and pharmaceuticals, where the solubility profile may greatly affect bioavailability and therapeutic efficacy.

Interesting facts

Interesting Facts about 1-Methyl-6-phenyl-1,2,3,4-tetrahydroisoquinoline

1-Methyl-6-phenyl-1,2,3,4-tetrahydroisoquinoline is a fascinating organic compound that belongs to the class of isoquinolines, which are known for their diverse biological activities. Here are some noteworthy points about this intriguing compound:

  • Unique Structure: This compound features a tetrahydroisoquinoline structure, distinguished by its bicyclic framework. The presence of both methyl and phenyl groups contributes to its distinctive properties and reactivity.
  • Biological Significance: Isoquinolines are often studied for their potential pharmacological applications. They exhibit a range of biological activities, including antidepressant, analgesic, and anticancer effects.
  • Synthetical Interest: The synthesis of compounds like 1-methyl-6-phenyl-1,2,3,4-tetrahydroisoquinoline is a subject of interest among chemists. Various methods, such as Pictet-Spengler reaction, are employed to create such structures which can lead to the discovery of new medicinal agents.
  • Research Potential: Ongoing research aims to explore its interactions within biological systems. This compound could serve as a lead structure for drug development owing to its potential effects on neurotransmitter systems.
  • Versatility: Beyond its biological effects, this compound also serves as an important intermediate in organic synthesis, showcasing its versatility in chemical applications.

In summary, 1-methyl-6-phenyl-1,2,3,4-tetrahydroisoquinoline remains a compound of interest due to its unique structural aspects, potential therapeutic uses, and significant role in advancing the field of medicinal chemistry. As research progresses, we may uncover even more aspects of its chemistry and applications!

Synonyms
1,2,3,4-Tetrahydro-1-methyl-6-phenylisoquinoline
24464-40-2
DTXSID201240198
AKOS014013317