Skip to main content

Nitrazepam

ADVERTISEMENT
Identification
Molecular formula
C15H11N3O3
CAS number
146-22-5
IUPAC name
1-methyl-7-nitro-5-phenyl-3H-1,4-benzodiazepin-2-one
State
State

At room temperature, nitrazepam is in a solid state, specifically as a crystalline powder.

Melting point (Celsius)
227.00
Melting point (Kelvin)
500.15
Boiling point (Celsius)
257.00
Boiling point (Kelvin)
530.15
General information
Molecular weight
281.27g/mol
Molar mass
281.2750g/mol
Density
1.4350g/cm3
Appearence

Nitrazepam is a fine, white to pale yellow crystalline powder. It is sparingly soluble in water and more soluble in organic solvents such as ethanol and methanol.

Comment on solubility

Solubility of 1-methyl-7-nitro-5-phenyl-3H-1,4-benzodiazepin-2-one

The solubility of 1-methyl-7-nitro-5-phenyl-3H-1,4-benzodiazepin-2-one (C15H11N3O3) is an interesting aspect of its chemical behavior. As a member of the benzodiazepine family, this compound exhibits specific solubility characteristics influenced by its molecular structure.

Factors Influencing Solubility

Several factors play a crucial role in determining the solubility of this compound:

  • Polarity: The presence of functional groups such as the nitro group (-NO2) and carbonyl group (C=O) affects how well the compound interacts with solvents.
  • Hydrogen bonding: The potential for hydrogen bonding can facilitate solubility in polar solvents, whereas non-polar solvents may not dissolve the compound effectively.
  • Temperature: Solubility often increases with temperature, making the solubility behavior temperature-dependent.

Typically, compounds closely related to 1-methyl-7-nitro-5-phenyl-3H-1,4-benzodiazepin-2-one show moderate solubility in organic solvents such as ethanol and somewhat limited solubility in water. This characteristic may be attributed to the compound's relatively large hydrophobic phenyl group paired with its polar functional groups.

Practical Considerations

Understanding the solubility of this compound is vital for applications in:

  • Pharmaceutical formulations, where solubility can influence absorption and bioavailability.
  • Analytical processes, including methods for extraction or chromatography.

In conclusion, the solubility of 1-methyl-7-nitro-5-phenyl-3H-1,4-benzodiazepin-2-one is not only a fundamental property but also a significant factor affecting its utilization in various chemical and pharmaceutical applications. As with many compounds, solubility behavior can be complex and is subject to further exploration.

Interesting facts

Interesting Facts About 1-Methyl-7-nitro-5-phenyl-3H-1,4-benzodiazepin-2-one

1-Methyl-7-nitro-5-phenyl-3H-1,4-benzodiazepin-2-one is a complex compound belonging to the benzodiazepine class, which is renowned for its various pharmacological properties. This compound is particularly intriguing due to its unique structure and the diverse biological activities that it can exhibit.

Key Insights:

  • Medicinal Use: The benzodiazepine derivatives are often used for their anxiolytic, sedative, and muscle-relaxant effects. This specific compound is of interest for research related to anxiety and sleep disorders.
  • Structure-Activity Relationship: The combination of a nitro group and a phenyl moiety is noteworthy, as these substituents can significantly influence the compound's interaction with neurotransmitter receptors.
  • Synthesis Challenges: The synthetic route for creating this benzodiazepine is often complex, involving multiple steps and careful control of reaction conditions to achieve the desired modifications on the benzodiazepine scaffold.
  • Research Potential: Studies are ongoing to explore its effectiveness and safety profile, opening avenues for the development of new therapeutic agents.

As a chemistry student or a scientist delving into this compound, consider the implications of its chemical structure on its biological activity. This compound serves as a prime example of how slight modifications at specific locations can lead to profound changes in pharmacological action. What discoveries await within the realms of its molecular interactions remains a compelling question in the field of medicinal chemistry.

In conclusion, 1-methyl-7-nitro-5-phenyl-3H-1,4-benzodiazepin-2-one exemplifies the intricate dance between chemical structure and biological activity, making it a fascinating subject for continued research and exploration.

Synonyms
nimetazepam
2011-67-8
1-Methylnitrazepam
Elimin
Erimin
Methylnitrazepam
Nimetazepamum
1,3-Dihydro-1-methyl-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one
Ro 5-3453
S 1530
Nimetazepam [INN:JAN]
Nimetazepamum [INN-Latin]
1-Methyl-5-phenyl-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one
1-methyl-7-nitro-5-phenyl-3H-1,4-benzodiazepin-2-one
EINECS 217-931-5
1-Methyl-7-nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
S-1530
Erimin (TN)
BRN 0759813
DTXSID6023369
CHEBI:31912
2H-1,4-BENZODIAZEPIN-2-ONE, 1,3-DIHYDRO-1-METHYL-7-NITRO-5-PHENYL-
NIMETAZEPAM [MI]
NIMETAZEPAM [INN]
NIMETAZEPAM [JAN]
NIMETAZEPAM [MART.]
NIMETAZEPAM [WHO-DD]
DTXCID303369
4532264KW6
NCGC00164577-01
Nimetazepamum (INN-Latin)
NIMETAZEPAM (MART.)
Nimetazepam (1mg/ml in Methanol)
1-methyl-7-nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one
SMR000238177
CAS-2011-67-8
Dormalon
DEA No. 2837
UNII-4532264KW6
Nimetazepam (JAN/INN)
SCHEMBL79886
MLS000759521
MLS001424150
CHEMBL13341
Nimetazepam, 1mg/ml in Methanol
HMS2051L16
HMS3393L16
Tox21_112205
AKOS030239804
Tox21_112205_1
CCG-101044
FN26224
NC00294
NCGC00164577-02
NS00009644
D01593
A814257
Q6149812
7-nitro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one
217-931-5