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Thiothixene

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Identification
Molecular formula
C23H29N2S
CAS number
144-62-7
IUPAC name
1-methyl-N-phenyl-N-(2-thienylmethyl)piperidin-4-amine
State
State

At room temperature, thiothixene is in a solid state, specifically available as a powder.

Melting point (Celsius)
148.00
Melting point (Kelvin)
421.15
Boiling point (Celsius)
537.50
Boiling point (Kelvin)
810.60
General information
Molecular weight
443.59g/mol
Molar mass
443.5850g/mol
Density
1.2481g/cm3
Appearence

Thiothixene appears as a crystalline, off-white to buff-colored powder. It is typically odorless.

Comment on solubility

Solubility Overview

The compound 1-methyl-N-phenyl-N-(2-thienylmethyl)piperidin-4-amine exhibits an intriguing solubility profile that is influenced by several structural features. Understanding its solubility is vital for applications in both chemical synthesis and pharmacology.

Solubility Characteristics

  • Polarity: The presence of a piperidine ring combined with various functional groups contributes to the compound's overall polarity.
  • Aromatic Interactions: The phenyl group and thiophene moiety can facilitate interactions with solvents, often enhancing solubility in organic solvents.
  • Hydrogen Bonding: With amine functionalities, the potential for hydrogen bonding can play a significant role in solubility in polar solvents like water.

In general, much of the solubility behavior can be summarized with the following observations:

  • It is likely to be more soluble in organic solvents rather than aqueous environments due to its complex structure.
  • Multiple polar functional groups can contribute to varying degrees of solubility based on the solvent employed.

As a general rule of thumb, "like dissolves like," which means that understanding both the solvent characteristics and the compound's functional groups is essential for predicting its solubility.

In conclusion, the solubility of 1-methyl-N-phenyl-N-(2-thienylmethyl)piperidin-4-amine is a nuanced topic requiring consideration of its intricate molecular structure and the chemical environment to understand its behavior comprehensively.

Interesting facts

Interesting Facts About 1-methyl-N-phenyl-N-(2-thienylmethyl)piperidin-4-amine

The compound 1-methyl-N-phenyl-N-(2-thienylmethyl)piperidin-4-amine is a fascinating chemical with diverse potential applications in the field of medicinal chemistry.

Structure and Functionality

  • Complex Structure: This compound features a piperidine ring, a common motif in many pharmaceuticals, contributing to its potential biological activity.
  • Thienyl Group: The presence of the thienyl group enhances the compound's interactions with biological targets, making it an interesting candidate for drug development.
  • Substituted Amine: The amine functional group plays a crucial role in forming hydrogen bonds, which is essential in the affinity of the compound towards various receptors.

Biological Significance

This compound has drawn interest due to its potential pharmacological properties:

  • Neurotransmitter Activity: Its structural components suggest it may interact with neurotransmitter systems, possibly influencing mood and cognition.
  • Research Applications: Compounds like this are often used in studies to explore mechanisms of action for cognitive enhancers and treatments for neuropsychiatric disorders.

Chemical Properties

Beyond its biological implications, the chemical properties of 1-methyl-N-phenyl-N-(2-thienylmethyl)piperidin-4-amine lend to its usability in various applications:

  • Synthetic Versatility: This compound can serve as a building block in organic synthesis, facilitating the creation of more complex molecules.
  • Interdisciplinary Research: It invites collaboration between chemists and biologists, fostering innovative approaches to drug design and development.

In conclusion, 1-methyl-N-phenyl-N-(2-thienylmethyl)piperidin-4-amine stands out as a compound of interest due to its unique structural features and promising biological activity. As research continues, it could pave the way for new therapeutic avenues, thereby marking its significance in contemporary chemistry.

Synonyms
Thenalidine
Thenophenopiperidine
Thenaldine
86-12-4
1-Methyl-4-N-2-thenylanilinopiperidine
Tenalidina
Thenalidinum
1-Methyl-4-amino-N-phenyl-N-(2-thenyl)piperidine
4-Piperidinamine, 1-methyl-N-phenyl-N-(2-thienylmethyl)-
DTXSID1048835
1-methyl-4-(N-2-thenylanilino)piperidine
6U94N2D00F
DTXCID8028761
1-methyl-N-phenyl-N-((thiophen-2-yl)methyl)piperidin-4-amine
1-Methyl-N-phenyl-N-[(thiophen-2-yl)methyl]piperidin-4-amine
D04AA03
R06AX03
201-651-5
Sanbosten
1-methyl-N-phenyl-N-(thiophen-2-ylmethyl)piperidin-4-amine
Piperidine, 1-methyl-4-(N-2-thenylanilino)-
Thenalidine (INN)
NCGC00183847-01
THENALIDINE [INN]
Tenalidina [INN-Spanish]
Thenalidinum [INN-Latin]
thenalidin
Sanbosten; Sandostene; Thenaldine; Thenalidin;Thenophenopiperidine
Thenalidine [INN:BAN]
EINECS 201-651-5
AS 716
BRN 0244448
UNII-6U94N2D00F
THENALDINE [MI]
SCHEMBL29498
THENALIDINE [WHO-DD]
4-22-00-03760 (Beilstein Handbook Reference)
CHEMBL2105458
CHEBI:135187
Tox21_113317
DB04826
CAS-86-12-4
NS00006482
D07194
H20720
EN300-18563901
Q6578796
N-(1-Methyl-4-piperidinyl)-N-phenyl-N-(2-thienylmethyl)amine #
Thenalidine; 4-Piperidinamine, 1-methyl-N-phenyl-N-(2-thienylmethyl)-; 2-Thenylamine, N-(1-methyl-4-piperidyl)-N-phenyl- (5CI); Piperidine, 1-methyl-4-(N-2-thenylanilino)- (8CI); Piperidine, 1-methyl-4-N-thenylanilino- (6CI); 1-Methyl-N-phenyl-N-(2-thienylmethyl)-4-pi