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1-Methylindole-2-carboxylic acid

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Identification
Molecular formula
C10H9NO2
CAS number
941-58-2
IUPAC name
1-methylindole-2-carboxylic acid
State
State

At room temperature, 1-Methylindole-2-carboxylic acid is typically found in a solid state.

Melting point (Celsius)
130.00
Melting point (Kelvin)
403.15
Boiling point (Celsius)
401.80
Boiling point (Kelvin)
674.95
General information
Molecular weight
175.19g/mol
Molar mass
175.1890g/mol
Density
1.2950g/cm3
Appearence

1-Methylindole-2-carboxylic acid typically appears as a crystalline solid powder that can range in color from white to off-white.

Comment on solubility

Solubility of 1-methylindole-2-carboxylic acid

1-methylindole-2-carboxylic acid, with its intricate molecular structure, exhibits interesting solubility characteristics that are important for various applications.

This compound is known to be:

  • Soluble in organic solvents: It tends to dissolve well in polar organic solvents such as methanol, ethanol, and acetone. This solubility can be attributed to the presence of the carboxylic acid group, which interacts favorably with the solvent molecules.
  • Less soluble in water: Although there is potential for some solubility due to hydrogen bonding, its overall hydrophobic indole ring structure limits its ability to remain in aqueous solutions.

Overall, the solubility behavior can be summarized with the following key points:

  • Polar organic solvents enhance solubility.
  • Hydrophilic interactions refrain its solubility in water.

In research and practical applications, understanding the solubility of 1-methylindole-2-carboxylic acid is crucial for its use in pharmaceuticals, organic synthesis, and other chemical processes. As such, consider its solubility profile when exploring methodologies for its utilization.

Interesting facts

Interesting Facts about 1-Methylindole-2-Carboxylic Acid

1-Methylindole-2-carboxylic acid is a fascinating compound that holds significance in both organic chemistry and various biological applications. Here are some intriguing aspects of this compound:

  • Structural Characteristics: This compound is part of the indole family, which is characterized by a fused bicyclic structure. The presence of a methyl group and a carboxylic acid group adds to its unique properties and reactivity.
  • Biological Relevance: Indoles, including 1-methylindole-2-carboxylic acid, are often encountered in nature and can be found in various plant alkaloids. They are relevant in several biological processes, including neurotransmitter regulation and plant defense mechanisms.
  • Applications in Synthesis: The compound serves as an essential building block in organic synthesis, particularly in the pharmaceutical industry. Its derivatives are often utilized in the development of medicinal compounds that target various biological pathways.
  • Research Potential: Emerging studies suggest that 1-methylindole-2-carboxylic acid and its derivatives may exhibit potential anti-inflammatory and anticancer properties. This positions the compound as a candidate for further investigation in the field of drug development.
  • Environmental Impact: The compound contributes to our understanding of environmental chemistry, as some indole derivatives are known for their roles in the degradation of pollutants, highlighting their potential in bioremediation applications.

In conclusion, 1-methylindole-2-carboxylic acid is a compound rich in diversity and potential. Its applicability across various fields not only makes it a subject of interest but also extends its importance beyond traditional chemistry into the realms of biology and environmental science.

Synonyms
1-Methyl-1H-indole-2-carboxylic acid
16136-58-6
1H-INDOLE-2-CARBOXYLIC ACID, 1-METHYL-
1-Methyl-2-indolecarboxylic acid
BRN 0007274
DTXSID60167123
5-22-03-00015 (Beilstein Handbook Reference)
NSC 68357
DTXCID8089614
625-083-6
1-Methylindole-2-carboxylic acid
MFCD00005801
Indole-2-carboxylic acid, 1-methyl-
CHEMBL36834
NSC68357
N-Methylindolcarbonsaure
ChemDiv3_011259
SCHEMBL117186
SCHEMBL3483087
SCHEMBL3483102
MAHAMBLNIDMREX-UHFFFAOYSA-
N-methylindole-2-carboxylic acid
HMS1504P17
(N-methyl)indole-2-carboxylic acid
1-methyl-1H-indole carboxylic acid
ALBB-007751
1-methyl-1H-2-indolecarboxylic acid
BBL037008
BDBM50424778
NSC-68357
SBB049025
STK120292
1-methyl-1H-indol-2-carboxylic acid
AKOS000262610
CG-0519
CS-W007740
FM56787
PB40936
IDI1_028817
1-Methylindole-2-carboxylic acid, 98%
AC-22708
ST039851
SY050484
DB-027144
EU-0015870
M1519
EN300-51846
CS-007/03901012
Z57204959
F0919-4682
InChI=1/C10H9NO2/c1-11-8-5-3-2-4-7(8)6-9(11)10(12)13/h2-6H,1H3,(H,12,13)