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1-Methylisoquinoline

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Identification
Molecular formula
C10H9N
CAS number
3349-63-5
IUPAC name
1-methylisoquinoline
State
State

At room temperature, 1-methylisoquinoline is a liquid. It remains stable under normal conditions but should be stored away from oxidizing agents and direct sunlight to prevent degradation.

Melting point (Celsius)
12.00
Melting point (Kelvin)
285.15
Boiling point (Celsius)
258.00
Boiling point (Kelvin)
531.15
General information
Molecular weight
129.17g/mol
Molar mass
129.1720g/mol
Density
1.0838g/cm3
Appearence

1-Methylisoquinoline is a colorless to pale yellow organic liquid. It can sometimes appear slightly brown upon exposure to air due to oxidation. It has a pungent, characteristic aromatic odor typical of nitrogen-containing heterocycles.

Comment on solubility

Solubility of 1-methylisoquinoline

1-methylisoquinoline, a nitrogen-containing heterocyclic compound, exhibits notable solubility characteristics that are important for its practical applications.

In terms of solubility:

  • Organic Solvents: 1-methylisoquinoline is generally soluble in a variety of organic solvents such as ethanol, methanol, and chloroform. This solvent compatibility makes it useful in organic chemistry and pharmaceuticals.
  • Aqueous Solubility: The compound's solubility in water is limited. This can be attributed to its hydrophobic structure, which hinders its ability to interact favorably with water molecules.
  • pH Influence: The solubility may change with pH variations, particularly in acidic or basic solutions, leading to potential ionization and altered solubility profiles.

In summary, while 1-methylisoquinoline dissolves well in organic solvents, its interactions with water are considerably weaker, emphasizing its classification as primarily a hydrophobic compound. As noted, "solubility is a complex interplay of molecular structure and environmental conditions," highlighting the intricacies involved in understanding this compound's behavior in various media.

Interesting facts

Interesting Facts about 1-Methylisoquinoline

1-Methylisoquinoline is a fascinating compound belonging to the class of isoquinolines, which are bicyclic structures derived from benzene and pyridine rings. Here are some remarkable aspects of this compound:

  • Structure and Properties: The unique bicyclic structure of 1-methylisoquinoline contributes to its interesting electronic properties, making it a subject of study in the field of organic chemistry.
  • Natural Occurrence: Compounds related to isoquinolines are often found in various natural sources, including plants, where they can serve as alkaloids with medicinal properties.
  • Biological Activity: Similar isoquinoline derivatives have been observed to exhibit a range of biological activities, including antimicrobial, antitumor, and anti-inflammatory effects, making them potential candidates for pharmaceuticals.
  • Synthesis Techniques: 1-Methylisoquinoline can be synthesized through various methods, including the Bischler-Napieralski reaction or other multi-step synthetic routes. This versatility allows chemists to create derivatives for specialized applications.
  • Research Potential: Owing to its structural framework, 1-methylisoquinoline has garnered interest in materials science and organic electronics, particularly in light-emitting devices and organic solar cells.

In the words of a renowned chemist: "Understanding the diverse structures of alkaloids can lead to groundbreaking discoveries in drug development." This highlights the importance of compounds like 1-methylisoquinoline in ongoing scientific research.

Overall, the study of 1-methylisoquinoline opens up numerous avenues in both synthetic organic chemistry and medicinal applications, making it a compound worth exploring further.

Synonyms
1-METHYLISOQUINOLINE
1721-93-3
Isoquinaldine
Isoquinoline, 1-methyl-
1-Methyl-isoquinoline
UNII-Z96HOX9RT9
Z96HOX9RT9
EINECS 217-017-6
NSC 101175
NSC-101175
DTXSID20870904
58853-80-8
Isoquinoline, 1-methyl-(8CI)
DTXCID00818586
Isoquinoline, 1-methyl-(8CI)(9CI)
217-017-6
inchi=1/c10h9n/c1-8-10-5-3-2-4-9(10)6-7-11-8/h2-7h,1h
pbymyajonqzorl-uhfffaoysa-n
Isoquinoline, methyl-
CHEMBL364698
MFCD00006902
1-methyl isoquinoline
1-Methylisoquinoline, 97%
SCHEMBL70488
CHEBI:125469
BCP30416
BDBM50159268
NSC101175
AKOS015842462
BP-12703
TS-01867
DB-000536
Isoquinoline, methyl-;1-methyl isoquinoline
M0298
NS00048390
EN300-120889
Y10177
1-Methylisoquinoline; Isoquinaldine; NSC 101175
A811385
BRD-K02603382-001-01-0
Q27216088
Z1255415440