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Diphenhydramine

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Identification
Molecular formula
C17H21NO1
CAS number
58-73-1
IUPAC name
(1-methylpyrrolidin-3-yl) 2-methoxy-2,2-diphenyl-acetate
State
State

At room temperature, diphenhydramine is usually in a solid state. In environments conducive to melting, it can transition into a liquid form. In pharmaceuticals, it is typically found as a hydrochloride salt which makes it more water-soluble and easier to administer in liquid form as well.

Melting point (Celsius)
167.00
Melting point (Kelvin)
440.15
Boiling point (Celsius)
310.00
Boiling point (Kelvin)
583.15
General information
Molecular weight
255.35g/mol
Molar mass
255.3470g/mol
Density
1.0950g/cm3
Appearence

Diphenhydramine, in its pure form, appears as a white crystalline solid, which may also sometimes be found in granular powder form. The compound is hygroscopic, which means it can absorb moisture from the air. It's noted for being almost odorless but can have a slight, characteristic odor when impure. Solubility: It is soluble in water, chloroform, and ethanol, but its solubility can vary depending on the solvent used and the pH conditions.

Comment on solubility

Solubility of (1-methylpyrrolidin-3-yl) 2-methoxy-2,2-diphenyl-acetate

The solubility of (1-methylpyrrolidin-3-yl) 2-methoxy-2,2-diphenyl-acetate can be influenced by various factors, primarily due to its unique structure. This compound exhibits a blend of hydrophobic and hydrophilic characteristics, leading to distinctive solubility properties.

Key Factors Affecting Solubility:

  • Polarity: The presence of the methoxy group introduces some polarity, which can enhance solubility in polar solvents.
  • Hydrophobic Aromatic Rings: The diphenyl groups contribute significantly to hydrophobic interactions, making the compound less soluble in water but potentially soluble in organic solvents.
  • Temperature: As is common with many organic compounds, increasing temperature may improve solubility in organic solvents.

In general, it is expected that this compound would be:

  • Insoluble or poorly soluble in water, due to the bulky hydrophobic aromatic groups.
  • More soluble in organic solvents, such as ethanol or dichloromethane, where the hydrophobic characteristics can be effectively balanced.

Understanding the solubility profile of (1-methylpyrrolidin-3-yl) 2-methoxy-2,2-diphenyl-acetate is crucial for its application in various chemical processes and formulations. Always consider conducting solubility tests under different conditions for precise measurements.

Interesting facts

Interesting Facts about (1-methylpyrrolidin-3-yl) 2-methoxy-2,2-diphenyl-acetate

(1-methylpyrrolidin-3-yl) 2-methoxy-2,2-diphenyl-acetate is a fascinating compound that blends elements of organic chemistry with potential applications in various fields. Here are some intriguing aspects to consider:

  • Chemical Structure: This compound features a pyrrolidine ring, which is notable for its role in organic synthesis and natural products. The inclusion of diphenyl and a methoxy group adds to the complexity and functional versatility of the molecule.
  • Pharmaceutical Potential: Pyrrolidine derivatives have been the focus of research for their biological activities. Some studies suggest that compounds similar to this one could exhibit novel therapeutic effects, making them of interest in drug development.
  • Reactivity: The presence of the methoxy group could influence the reactivity of this compound, making it a potential candidate for various substitution reactions. This could lead to the synthesis of more complex structures with useful properties.
  • Synthesis: Chemists often explore novel reaction pathways for creating such compounds. Engaging in the synthesis of (1-methylpyrrolidin-3-yl) 2-methoxy-2,2-diphenyl-acetate could inspire innovative methodologies in organic chemistry.
  • Characterization Techniques: Characterizing this compound involves sophisticated techniques such as NMR spectroscopy and mass spectrometry. These methods allow scientists to elucidate the structure and confirm the purity of the compound, paving the way for further studies.

The networking of various functional groups within this compound provides a unique opportunity for research and development in both academic and industrial settings. As the field of medicinal chemistry continues to evolve, it is compounds like (1-methylpyrrolidin-3-yl) 2-methoxy-2,2-diphenyl-acetate that can lead to breakthrough discoveries in drug design and synthesis.