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1-Methylquinazolin-4-one

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Identification
Molecular formula
C9H8N2O
CAS number
4428-94-2
IUPAC name
1-methylquinazolin-4-one
State
State

At room temperature, 1-Methylquinazolin-4-one is typically in a solid crystalline state.

Melting point (Celsius)
172.50
Melting point (Kelvin)
445.65
Boiling point (Celsius)
364.00
Boiling point (Kelvin)
637.15
General information
Molecular weight
160.17g/mol
Molar mass
160.1740g/mol
Density
1.2224g/cm3
Appearence

1-Methylquinazolin-4-one typically appears as a yellow crystalline solid. Its crystalline structure and physical state can vary depending on the specific form and processing it undergoes.

Comment on solubility

Solubility Characteristics of 1-methylquinazolin-4-one

1-methylquinazolin-4-one, with its unique structure, presents intriguing solubility behavior in various solvents. Understanding the solubility of this compound is crucial, particularly for applications in pharmaceuticals and materials science. Here are some key points to note:

  • Solvent Compatibility: 1-methylquinazolin-4-one is generally soluble in polar organic solvents such as dimethyl sulfoxide (DMSO) and methanol. However, it exhibits limited solubility in non-polar solvents like hexane or chloroform.
  • Temperature Dependence: The solubility of 1-methylquinazolin-4-one can increase with temperature, highlighting the importance of thermal conditions in solvent selection.
  • pH Sensitivity: As with many organic compounds, the solubility of 1-methylquinazolin-4-one can be influenced by the pH of the solution, which may affect ionization and stabilization of the molecule.
  • Practical Considerations: When working with 1-methylquinazolin-4-one, it is advisable to test different solvents to determine the most effective medium for dissolving the compound for various applications.

In summary, the solubility of 1-methylquinazolin-4-one is comparatively favorable in polar mediums, with several factors influencing its behavior in different chemical environments. Understanding these factors can lead to more effective utilization of this compound in research and development.

Interesting facts

Interesting Facts about 1-Methylquinazolin-4-one

1-Methylquinazolin-4-one is an intriguing compound that belongs to the quinazolinone family, which is notable for its diverse biological activities and usefulness in medicinal chemistry. Here are some fascinating aspects of this compound:

  • Biological Significance: The quinazolinone derivatives, including 1-methylquinazolin-4-one, exhibit a broad spectrum of pharmacological properties. Research has indicated their potential as antitumor, anti-inflammatory, and antimicrobial agents.
  • Mechanistic Insights: This compound has garnered attention due to its ability to interact with various biological targets. It can influence several metabolic pathways, making it a promising candidate for drug development.
  • Synthetic Versatility: The synthesis of 1-methylquinazolin-4-one can be achieved through multiple methods, showcasing its versatility in the laboratory. Various synthetic routes allow chemists to explore modifications to enhance its efficacy and reduce side effects.
  • Research Applications: Scientists are actively investigating 1-methylquinazolin-4-one for its role in developing therapies against diseases like cancer and infections. The compound serves as a significant lead structure for the design of new drug candidates.
  • Structural Role: The quinazolinone scaffold provides a unique framework for modifying chemical properties. This structural diversity allows for exploring new interactions that may lead to novel therapeutic agents.

In summary, 1-methylquinazolin-4-one stands out not only for its rich chemistry but also for its potential impact on medicinal science. Continual research into this compound might lead to significant advancements in the pharmaceutical field, providing hope for innovative treatments that leverage its unique properties.

Synonyms
Glycorine
1-Methyl-4(1H)-quinazolinone
4(1H)-QUINAZOLINONE, 1-METHYL-
1-methylquinazolin-4-one
GHK8W83JM1
NSC 94558
BRN 0127680
NSC-94558
UNII-GHK8W83JM1
1-METHYL-4-QUINAZOLONE
DTXSID00188312
5-24-03-00048 (Beilstein Handbook Reference)
DTXCID30110803
qaxcwbivfceygg-uhfffaoysa-n
1-Methylquinazolin-4(1H)-one
3476-68-4
1-methyl-1,4-dihydroquinazolin-4-one
Glycorin
NSC94558
SCHEMBL1304538
KUC112567N
MFCD01685943
AKOS006373184
KSC-321-040
AS-49991
DS-003098
quinazoline, 1,4-dihydro-1-methyl-4-oxo-
O10431
AC-907/34120056