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1-Methylquinolin-4-one

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Identification
Molecular formula
C10H9NO
CAS number
491-35-0
IUPAC name
1-methylquinolin-4-one
State
State

At room temperature, 1-methylquinolin-4-one is a solid. It is stable under standard conditions and does not readily transition to a liquid or gas phase without the application of significant heat.

Melting point (Celsius)
78.00
Melting point (Kelvin)
351.15
Boiling point (Celsius)
312.90
Boiling point (Kelvin)
586.05
General information
Molecular weight
173.19g/mol
Molar mass
173.1910g/mol
Density
1.2060g/cm3
Appearence

1-Methylquinolin-4-one appears as a yellow crystalline solid. The compound is known for its intensely colored crystals which may appear slightly orange under certain lighting conditions.

Comment on solubility

Solubility of 1-methylquinolin-4-one

1-methylquinolin-4-one, a derivative of quinoline, is known for its intriguing solubility characteristics. When assessing the solubility of this compound, several important factors come into play:

  • Solvent Type: 1-methylquinolin-4-one exhibits variable solubility depending on the solvent. It is generally soluble in organic solvents like ethanol and methanol due to its non-polar structure.
  • Temperature Influence: Like many organic compounds, the solubility of 1-methylquinolin-4-one increases with temperature, making heating a useful method to enhance dissolution.
  • Polarity Consideration: The presence of the carbonyl group (C=O) in the structure contributes to its ability to interact with polar solvents, but overall it remains more compatible with non-polar systems.
  • Crystal Structure: The crystalline nature of this compound can also affect its solubility, as highly ordered solids may dissolve less readily compared to amorphous forms.

In summary, while 1-methylquinolin-4-one shows a propensity for solubility in organic solvents, it is critical to consider factors like solvent type, temperature, and structural characteristics to fully understand its solubilization behavior. As with many compounds, the general guideline is: the solubility of a substance increases with temperature and is influenced by the solvent's polarity.

Interesting facts

Interesting Facts About 1-Methylquinolin-4-one

1-Methylquinolin-4-one is a fascinating compound that falls within the class of quinolines, a group known for their rich presence in both pharmaceuticals and natural products. Here are some intriguing aspects of this compound:

  • Pharmacological Significance: This compound has been studied for its biological activities, particularly as potential antimicrobial and anticancer agents. Its structural properties enable interactions that can disrupt cellular processes, making it a candidate for drug development.
  • Fluorescent Properties: 1-Methylquinolin-4-one exhibits interesting fluorescent properties, which makes it useful in various applications, including chemical sensing and bioimaging techniques.
  • Synthetic Versatility: The synthesis of this compound can be accomplished through multiple methods, often involving the condensation of specific precursors. This versatility opens pathways for the creation of derivatives that can enhance its biological activity or improve solubility in various media.
  • Role in Organic Chemistry: In the field of organic synthesis, quinoline derivatives are vital as they participate in significant reactions such as Friedlander synthesis and oxidative coupling. 1-Methylquinolin-4-one can serve as a valuable building block in these reactions, expanding the toolkit for organic chemists.
  • Natural Occurrences: Alkaloids containing quinoline structures have been isolated from plants, linking 1-methylquinolin-4-one to the expansive world of natural products, providing insights into botanical chemistry and potential therapeutic uses.

Given these characteristics, 1-methylquinolin-4-one is not just a compound of interest due to its structure, but also because of its diverse applications and the ongoing research that continues to unveil its potential.

Synonyms
Echinopsine
83-54-5
1-Methyl-4-quinolone
1-methylquinolin-4-one
Echinopsin
1-methylquinolin-4(1H)-one
N-Methyl-4-quinolone
1-Methyl-4(1H)-quinolone
4(1H)-Quinolinone,1-methyl-
N-Methyl-gamma-quinoline
1-Methyl-4(1H)-quinolinone
1-methyl-1,4-dihydroquinolin-4-one
1,4-Dihydro-1-methyl-4-oxoquinoline
Ekhinopsin
4(1H)-QUINOLONE, 1-METHYL-
4(1H)-Quinolinone, 1-methyl-
UNII-17MMY7OK1U
EINECS 201-485-3
17MMY7OK1U
BRN 0122247
N-Methylquinolin-4-one
1-Methyl-4-quinolinone
ECHINOPSINE [MI]
N-Methyl-.gamma.-quinolinone
DTXSID30232110
5-21-08-00210 (Beilstein Handbook Reference)
MFCD00179581
N-Methyl-gamma-quinolinone
1-methyl-1h-quinolin-4-one
CHEBI:4749
SCHEMBL1809581
DTXCID30154601
HMS1648C04
AAA08354
BBL028347
EX-A11523
STL372984
AKOS000277978
VS-08731
quinoline, 1,4-dihydro-1-methyl-4-oxo-
NS00022827
D86440
EN300-7424849
Q4533321
Z1198151716