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1-nitro-2-(trifluoromethyl)benzene

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Identification
Molecular formula
C7H4F3NO2
CAS number
1333-72-4
IUPAC name
1-nitro-2-(trifluoromethyl)benzene
State
State

This compound is typically in a liquid state at room temperature.

Melting point (Celsius)
-1.00
Melting point (Kelvin)
272.15
Boiling point (Celsius)
217.70
Boiling point (Kelvin)
490.85
General information
Molecular weight
189.12g/mol
Molar mass
189.1150g/mol
Density
1.4460g/cm3
Appearence

1-nitro-2-(trifluoromethyl)benzene is a colorless to light yellow liquid. It may appear slightly viscous and has an aromatic odor.

Comment on solubility

Solubility of 1-nitro-2-(trifluoromethyl)benzene

When discussing the solubility of 1-nitro-2-(trifluoromethyl)benzene, several key factors come into play:

  • Polarity: The presence of a nitro group (−NO₂) makes this compound more polar, while the trifluoromethyl group (−CF₃) introduces steric hindrance and hydrophobic character. This combination can result in moderate solubility in polar solvents.
  • Solvent Interactions: The solubility is primarily observed in organic solvents like ethanol and acetone. However, the presence of nonpolar components can lead to reduced solubility in highly polar solvents such as water.
  • Temperature Dependence: Typically, solubility may increase with rising temperatures; thus, heat can enhance the dissolution process for this compound in compatible solvents.

It is important to note that the solubility behavior can also be influenced by the specific conditions of the system, such as pressure and concentration of other solutes. As a general observation, because of its molecular structure, 1-nitro-2-(trifluoromethyl)benzene may precipitate in aqueous conditions while remaining more soluble in organic mixtures. Therefore, when experimenting with this compound, one should carefully consider the choice of solvent and the expected temperature conditions.

Interesting facts

Facts About 1-Nitro-2-(trifluoromethyl)benzene

1-Nitro-2-(trifluoromethyl)benzene, often just called 2-Trifluoromethyl-1-nitrobenzene, is a fascinating compound in the field of organic chemistry. This compound can be appreciated not just for its unique structure but also for its various applications and potential in scientific research.

Structure and Functional Groups

What makes this compound particularly interesting is its combination of functional groups:

  • Nitro group (-NO2): Known for its electron-withdrawing properties, it significantly influences the reactivity and polarization of the aromatic ring.
  • Trifluoromethyl group (-CF3): This group imparts unique electronic characteristics and enhances lipophilicity, making the molecule useful in drug discovery and materials science.

Applications in Research

The unique characteristics of 1-nitro-2-(trifluoromethyl)benzene have led to its use in various research domains:

  • Pharmaceuticals: The compound's functional groups can aid in the development of new drugs, as modifications may lead to better efficacy or reduced toxicity.
  • Materials Science: Its properties make it an excellent candidate for studying new materials, including polymers and coatings with enhanced chemical stability.
  • Agricultural Chemicals: Compounds in this family can sometimes be utilized in creating pesticides and herbicides, showcasing their versatility.

Interesting Chemical Behavior

This compound exhibits some intriguing chemical behaviors due to the presence of the nitro and trifluoromethyl groups. Generally, nitro compounds are known to be:

  • Reactive towards nucleophiles, allowing for interesting synthesis routes.
  • Strong electrophiles, making them susceptible to electrophilic substitution reactions.

As with many aromatic compounds, the electron-withdrawing effects of the nitro and trifluoromethyl groups can lead to enhanced reactivity under specific conditions.

Conclusion

1-Nitro-2-(trifluoromethyl)benzene stands out as a compound of interest due to its structural and chemical properties. It's a prime example of how functional groups can alter the behavior and potential applications of organic compounds. In the ever-evolving landscape of chemical research, compounds like this offer exciting avenues for exploration!

Synonyms
2-Nitrobenzotrifluoride
384-22-5
1-Nitro-2-(trifluoromethyl)benzene
o-Nitrobenzotrifluoride
2-NITRO-ALPHA,ALPHA,ALPHA-TRIFLUOROTOLUENE
Benzene, nitro(trifluoromethyl)-
o-(Trifluoromethyl)nitrobenzene
HSDB 4260
Benzene, 1-nitro-2-(trifluoromethyl)-
CCRIS 2813
UNII-OVB3L8GIVJ
1-Nitro-2-trifluoromethyl-benzene
EINECS 206-855-8
2-(Trifluoromethyl)nitrobenzene
DTXSID4025793
OVB3L8GIVJ
MFCD00007145
DTXCID805793
2-Nitro-.alpha.,.alpha.,.alpha.-trifluorotoluene
.alpha.,.alpha.,.alpha.-Trifluoro-o-nitrotoluene
Toluene, .alpha.,.alpha.,.alpha.-trifluoro-o-nitro-
Toluene, 2-nitro-.alpha.,.alpha.,.alpha.-trifluoro-
NITRO-.ALPHA.,.ALPHA.,.ALPHA.-TRIFLUOROTOLUENE, 2-
2-NITRO-.ALPHA.,.ALPHA.,.ALPHA.-TRIFLUOROTOLUENE [HSDB]
CAS-384-22-5
2-Nitro-a,a,a-trifluorotoluene
alpha,alpha,alpha-Trifluoro-o-nitrotoluene
Toluene, alpha,alpha,alpha-trifluoro-o-nitro-
2-TRIFLUOROMETHYLNITROBENZENE
oNitrobenzotrifluoride
2Nitrobenzotrifluoride
2-Nitrotrifluoromethylbenzene
o(Trifluoromethyl)nitrobenzene
1Nitro2(trifluoromethyl)benzene
SCHEMBL1999849
CHEMBL3182055
1-Nitro-2(trifluoromethyl)benzene
Benzene, 1nitro2(trifluoromethyl)
Tox21_201264
Tox21_303057
1-nitro-2-(trifluoromethyl)-benzene
UN2306
AKOS005259564
alpha,alpha,alphaTrifluoroonitrotoluene
AC-4152
CS-W002022
GS-3373
NCGC00249011-01
NCGC00257176-01
NCGC00258816-01
Toluene, alpha,alpha,alphatrifluoroonitro
SY020734
NS00042223
Toluene, 2-nitro-alpha,alpha,alpha-trifluoro-
o-Nitro-.alpha.,.alpha.,.alpha.-trifluorotoluene
NITRO-ALPHA,ALPHA,ALPHA-TRIFLUOROTOLUENE, 2-
Q27285862
F0001-1092
1-Nitro-2-(trifluoromethyl)benzene, 2-(Trifluoromethyl)nitrobenzene