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1-nitropiperidine

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Identification
Molecular formula
C5H10N2O2
CAS number
1129-39-1
IUPAC name
1-nitropiperidine
State
State

1-Nitropiperidine is typically found as a liquid at room temperature, and it remains stable under standard conditions.

Melting point (Celsius)
-46.00
Melting point (Kelvin)
227.15
Boiling point (Celsius)
220.00
Boiling point (Kelvin)
493.15
General information
Molecular weight
130.16g/mol
Molar mass
130.1620g/mol
Density
1.1680g/cm3
Appearence

1-Nitropiperidine typically appears as a colorless to pale-yellow liquid. It can have a pungent odor that is often characteristic of nitro compounds.

Comment on solubility

Solubility of 1-Nitropiperidine

1-Nitropiperidine, with the chemical formula C5H9N2O2, exhibits interesting solubility characteristics. Understanding its solubility can provide valuable insights for its applications in various chemical processes.

Key Aspects of Solubility

  • Polarity: Due to the presence of the nitro group, 1-nitropiperidine tends to have moderate polarity, which can affect its solubility in different solvents.
  • Solvent Interaction: It is generally soluble in polar solvents such as water, alcohols, and polar organic solvents. This is essential for its usability in polar environments.
  • Temperature Dependence: Like many organic compounds, the solubility of 1-nitropiperidine may increase with temperature, making it easier to dissolve in hot solvents.
  • Application Impact: The solubility properties contribute to 1-nitropiperidine's functionality in synthetic chemistry and drug formulation.

In summary, the solubility of 1-nitropiperidine in various solvents highlights its versatility and importance in chemical applications. Its moderate polarity and solubility dynamics facilitate effective interactions in solution, an essential consideration for researchers and industrial chemists alike.

Interesting facts

Interesting Facts about 1-Nitropiperidine

1-Nitropiperidine is a fascinating organic compound that belongs to the class of nitro derivatives of piperidine. Here are some intriguing aspects of this compound:

  • Structure and Stability: The presence of the nitro group increases the molecular polarity, which can influence the compound's reactivity and interactions with other substances.
  • Versatile Intermediary: 1-Nitropiperidine acts as a versatile intermediate in the synthesis of various pharmaceuticals and agrochemicals, showcasing its significance in medicinal chemistry.
  • Functionalization: This compound can be further functionalized to create a diverse array of substituted piperidine derivatives, aiding in drug development.
  • Biological Activity: Research into nitropiperidines has revealed potential biological activities, making them interesting candidates for the investigation of new therapeutic agents.

Applications in Research

The exploration of 1-nitropiperidine extends beyond organic synthesis; its role as a building block in medicinal chemistry is particularly noteworthy. It has been involved in:

  • Developing central nervous system agents.
  • Investigating compounds with antihypertensive properties.
  • Contributing to research on anti-inflammatory drugs.

Safety and Handling

When working with 1-nitropiperidine, safety is paramount. Researchers must observe standard laboratory protocols, including the use of personal protective equipment (PPE) and adequate ventilation, to mitigate any hazardous influences of nitro compounds.

In summary, 1-nitropiperidine stands out in the chemical landscape not just for its structural attributes but also for its extensive applications and potential in the realm of drug discovery and development.

Synonyms
N-NITROPIPERIDINE
Piperidine, 1-nitro-
1-nitro-piperidine
7119-94-0
nitropiperidine
SCHEMBL2347952
DTXSID60221390
PFHGNIMWELIXGP-UHFFFAOYSA-N
AKOS015905384