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Phenylephrine Hydrochloride

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Identification
Molecular formula
C9H13NO2 · HCl
CAS number
61-76-7
IUPAC name
1-phenyl-2-(pyrimidin-2-ylamino)ethanol;hydrochloride
State
State

Phenylephrine hydrochloride is typically a solid at room temperature. It is most commonly encountered as a crystalline powder used in medications for its decongestant properties.

Melting point (Celsius)
146.00
Melting point (Kelvin)
419.00
Boiling point (Celsius)
150.00
Boiling point (Kelvin)
423.00
General information
Molecular weight
203.27g/mol
Molar mass
203.2740g/mol
Density
1.2200g/cm3
Appearence

Phenylephrine hydrochloride appears as a white to off-white crystalline powder. It is soluble in water and alcohol, which makes it suitable for use in pharmaceutical formulations.

Comment on solubility

Solubility of 1-phenyl-2-(pyrimidin-2-ylamino)ethanol;hydrochloride

The solubility of 1-phenyl-2-(pyrimidin-2-ylamino)ethanol;hydrochloride is influenced by several factors, making it an interesting compound to study in terms of solubility properties. As a hydrochloride salt, it generally exhibits the following characteristics:

  • High Solubility in Water: Being a hydrochloride salt, it tends to be more soluble in aqueous solutions compared to its free base form. This enhanced solubility can be attributed to the ionic nature of the salt, which allows it to interact favorably with water molecules.
  • Temperature Dependence: The solubility can increase with temperature, which is common for many salts. Higher temperatures often lead to increased molecular movement, allowing more solute to dissolve.
  • pH Influence: The solubility of this compound may also be affected by the pH of the solution. In more acidic conditions, the protonation of amino groups can further enhance its solubility.

As noted in solubility studies, "the solubility behavior of salts can vary significantly based on ionic interactions in the solvent." Therefore, practicing careful control of the solvent environment will yield the best insights into its solubility attributes.

In solid-state, this compound's conformational stability may also hint at possible solubility challenges in nonpolar solvents where it may exhibit lower solubility. Thus, understanding the solubility landscape of 1-phenyl-2-(pyrimidin-2-ylamino)ethanol;hydrochloride is key for applications in pharmaceuticals and chemical formulations.

Interesting facts

Interesting Facts about 1-phenyl-2-(pyrimidin-2-ylamino)ethanol; hydrochloride

1-phenyl-2-(pyrimidin-2-ylamino)ethanol; hydrochloride is a fascinating compound that presents several intriguing aspects, especially in the realm of medicinal chemistry. Here are some noteworthy points:

  • Pharmacological Potential: This compound is often explored for its potential as a therapeutic agent. Its structure suggests that it may interact with biological targets, making it an interesting candidate for drug development.
  • Structure Activity Relationship (SAR): The presence of both a phenyl and a pyrimidine ring in its structure offers various avenues for modifications, potentially enhancing its efficacy and selectivity against specific targets.
  • Research Applications: Researchers are investigating compounds like this one for their possible roles in treating neurological disorders or cancer, due to their ability to influence cellular signaling pathways.
  • Synthesis Techniques: The synthesis of such compounds often involves intricate synthetic pathways that can teach students valuable lessons in organic synthesis techniques, including amination and ring closure reactions.
  • Derivative Studies: Derivatives of this molecule can lead to fascinating studies in structure modification, enabling scientists to understand how slight changes in molecular structure can lead to significant changes in biological activity.
  • Real-World Relevance: Compounds that resemble this chemical often appear in clinical trials, showcasing their relevance in real-world medicine and the importance of such studies in advancing human health.

In the words of the famous chemist Linus Pauling, "The best way to have a good idea is to have a lot of ideas." This underscores the importance of exploring various compounds and their potential, such as 1-phenyl-2-(pyrimidin-2-ylamino)ethanol; hydrochloride, which could lead to groundbreaking therapeutic advancements.

Synonyms
Fenyripol hydrochloride
Fenyripol HCl
2441-88-5
IN 836
Fenyripol hydrochloride [USAN]
IN 836 (VAN)
UNII-R4I084C0NO
NSC 43183
NSC-43183
R4I084C0NO
IN-836
Benzenemethanol, alpha-((2-pyrimidinylamino)methyl)-, monohydrochloride
Fenyripol Hydrochloride (USAN)
2-(beta-Hydroxy-beta-phenethylamino)-pyrimidine hydrochloride
alpha-((2-Pyrimidinylamino)methyl)benzyl alcohol hydrochloride
alpha-((2-Pyrimidinylamino)methyl)benzyl alcohol monohydrochloride
Benzyl alcohol, alpha-(2-pyrimidinylaminomethyl)-, hydrochloride
2-(beta-Hydroxy-beta-phenyl-ethyl-amino)-pyrimidine chlorhydrate [French]
NSC43183
2-(beta-Hydroxy-beta-phenyl-ethyl-amino)-pyrimidine chlorhydrate
BENZYL ALCOHOL, alpha-((2-PYRIMIDINYLAMINO)METHYL)-, MONOHYDROCHLORIDE
BENZENEMETHANOL, .ALPHA.-((2-PYRIMIDINYLAMINO)METHYL)-, MONOHYDROCHLORIDE
.alpha.-[(2-Pyrimidinylamino)methyl]benzyl alcohol monohydrochloride
alpha-[(2-Pyrimidinylamino)methyl]benzyl alcohol monohydrochloride
.ALPHA.-((2-PYRIMIDINYLAMINO)METHYL)BENZYL ALCOHOL MONOHYDROCHLORIDE
1-phenyl-2-(pyrimidin-2-ylamino)ethanol;hydrochloride
.alpha.-(2-Pyrimidinylaminomethyl)benzyl alcohol hydrochloride
SCHEMBL120829
CHEMBL2106557
AKOS040751796
D04165
Q27287786
2-[(.beta.-Hydroxyphenethyl)amino]pyrimidine hydrochloride