1-Phenyl-3-(p-tolylsulfonyl)isothiourea

Identification

Molecular formula

C₁₄H₁₄N₂O₂S

CAS number

25828-99-9

IUPAC name

1-phenyl-3-(p-tolylsulfonyl)isothiourea

State

This compound is typically a solid at room temperature, characterized by its powdery form, which is white to off-white in color, making it identifiable and manageable during experimental handling.

Melting point (Celsius)

172.00

Melting point (Kelvin)

445.15

Boiling point (Celsius)

442.90

Boiling point (Kelvin)

716.05

General information

Molecular weight

278.35g/mol

Molar mass

278.3550g/mol

Density

1.2900g/cm³

Appearence

1-Phenyl-3-(p-tolylsulfonyl)isothiourea is a solid compound that can be characterized by its crystalline appearance. It usually appears as a white to off-white powder. Its solid state and coloration make it relatively easy to handle in laboratory environments.

Comment on solubility

Solubility of 1-phenyl-3-(p-tolylsulfonyl)isothiourea

The solubility of 1-phenyl-3-(p-tolylsulfonyl)isothiourea, a compound characterized by its unique functional groups, can be influenced by several factors:

Polarity: The presence of the sulfonyl group enhances polarity, which typically increases solubility in polar solvents.
Hydrogen Bonding: The isothiourea moiety is capable of forming hydrogen bonds, which can improve solubility in solvents that can participate in such interactions.
Effect of Substituents: The phenyl and p-tolyl groups contribute to the hydrophobic character of the molecule, potentially limiting solubility in strictly aqueous environments.
Common Solvents: This compound may exhibit good solubility in common organic solvents like DMSO, DMF, or methanol due to favorable interactions.

Overall, while the solubility of 1-phenyl-3-(p-tolylsulfonyl)isothiourea is influenced by its molecular structure, it is expected to be more soluble in polar organic solvents rather than in non-polar media. Understanding the solubility characteristics of this compound is essential for its application in various chemical processes.

Interesting facts

Exploring 1-phenyl-3-(p-tolylsulfonyl)isothiourea

1-phenyl-3-(p-tolylsulfonyl)isothiourea is a fascinating compound that has garnered attention in various fields of research due to its unique structure and properties. Here are some interesting facts about this compound:

Chemical Structure: This compound features a distinctive isothiourea group, which is known for its ability to form strong bonds with various substrates, making it a valuable compound in medicinal chemistry.
Biological Activity: Research has indicated that derivatives of isothiourea can exhibit significant biological activity, including antitumor and antifungal properties. This makes 1-phenyl-3-(p-tolylsulfonyl)isothiourea a potential candidate for further pharmacological studies.
Reactivity: The presence of a sulfonyl group enhances the compound's reactivity, allowing for various chemical transformations, which can lead to the synthesis of novel compounds with enhanced biological activity.
Synthetic Route: The synthesis of isothioureas often involves a straightforward reaction between isothiocyanates and amines, offering a practical approach for chemists interested in exploring this class of compounds.
Applications: Beyond medicinal uses, compounds in the isothiourea family can serve as catalysts in organic reactions, showcasing their versatility in synthetic chemistry.

As chemists continue to explore the implications of this compound, it is clear that 1-phenyl-3-(p-tolylsulfonyl)isothiourea holds significant promise in both basic and applied research fields. The ongoing studies will undoubtedly illuminate further applications and enhance our understanding of its properties.