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4'-Piperidinoacetophenone

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Identification
Molecular formula
C15H21NO
CAS number
53617-36-0
IUPAC name
1-phenyl-4-(1-piperidyl)butan-1-one
State
State

At room temperature, 4'-Piperidinoacetophenone exists as a solid.

Melting point (Celsius)
49.00
Melting point (Kelvin)
322.15
Boiling point (Celsius)
398.00
Boiling point (Kelvin)
671.15
General information
Molecular weight
229.34g/mol
Molar mass
229.3230g/mol
Density
1.0922g/cm3
Appearence

4'-Piperidinoacetophenone appears as a crystalline solid. The compound can display a color range from white to off-white.

Comment on solubility

Solubility of 1-phenyl-4-(1-piperidyl)butan-1-one

1-phenyl-4-(1-piperidyl)butan-1-one, often referred to as PPB, exhibits unique solubility characteristics that can influence its application in various fields including pharmaceuticals and organic synthesis. The solubility of this compound is primarily dictated by its structure and the functional groups present.

Factors Affecting Solubility

  • Polarity: The presence of the piperidine ring contributes to the overall polarity of the compound, which can enhance its solubility in polar solvents.
  • Hydrogen Bonding: The nitrogen in the piperidine can participate in hydrogen bonding, potentially increasing solubility in polar solvents like water.
  • Steric Hindrance: The bulky phenyl group may introduce steric hindrance causing variable solubility in different solvent systems.

In general, 1-phenyl-4-(1-piperidyl)butan-1-one is likely to have limited solubility in non-polar solvents but may dissolve more readily in polar organic solvents such as ethanol or methanol. As a result, it’s particularly valuable in scenarios where a particular solvent's properties can enhance solubility. Exploratory studies suggest that:

  • It may show moderate solubility in common organic solvents.
  • Its solubility can be substantially increased through solubilizing agents in formulations.

To summarize, understanding the solubility of PPB is crucial for its effective utilization in various chemical applications, and further studies can help elucidate its behavior in different environmental and chemical contexts.

Interesting facts

Interesting Facts About 1-Phenyl-4-(1-Piperidyl)butan-1-one

1-Phenyl-4-(1-piperidyl)butan-1-one, often referred to in scientific circles for its unique structure and potential applications, presents intriguing characteristics and relevance in various fields of research. Here are several noteworthy points:

  • Pharmacological Potential: This compound has garnered attention within the medicinal chemistry community for its potential use in synthesizing novel pharmaceutical agents. Its unique combination of phenyl and piperidyl groups can influence the biological activity of derivatives.
  • Structural Insights: The structure of 1-phenyl-4-(1-piperidyl)butan-1-one illustrates a fascinating interplay between aliphatic and aromatic rings, contributing to its diverse reactivity. The functional groups involved bolster its capability to form various derivatives.
  • Research Applications: Studies have highlighted its role in the development of compounds aimed at targeting specific receptors, making it significant in the pursuit of medicines for neurodegenerative and psychiatric disorders.
  • Synthon Utility: This compound serves as an important synthon in organic synthesis, especially in reaction pathways focusing on amine alterations, demonstrating its versatility in synthetic organic chemistry.
  • Historical Relevance: While its research may be relatively new, it is chained to the larger legacy of piperidine derivatives, which have long been studied due to their complex effects on central nervous system activity.

In conclusion, 1-phenyl-4-(1-piperidyl)butan-1-one is a compound that extends far beyond its chemical simplicity. As researchers continue to unravel its properties and applications, it stands at the intersection of chemistry and biology, exemplifying the impact that individual compounds can have on scientific progress. As noted by one researcher, "The potential of such compounds lies not just in their structures but in how we leverage them for innovation."

Synonyms
4-Piperidinobutyrophenone
4476-25-9
3'-(1-Piperidyl)butyrophenone
BRN 0167020
BUTYROPHENONE, 4-PIPERIDINO-
1-Butanone, 1-phenyl-4-(1-piperidinyl)-
DTXSID20196297
5-20-02-00354 (Beilstein Handbook Reference)
DTXCID30118788
1-Butanone, 1-phenyl-4-(1-piperidinyl)-(9CI)
1-Butanone, 1-phenyl-4-(1-piperidinyl)- (9CI)
SCHEMBL7645836
WLTFPYVGECWXFO-UHFFFAOYSA-N
AKOS009057804
1-phenyl-4-(1-piperidinyl)butan-1-one