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1-Phenyl-4-(2-(2H-tetrazol-5-yl)ethyl)piperazine

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Identification
Molecular formula
C13H18N6
CAS number
156488-17-4
IUPAC name
1-phenyl-4-[2-(2H-tetrazol-5-yl)ethyl]piperazine
State
State

At room temperature, this compound is a solid, primarily in a crystalline powder form. It is stable under normal conditions but should be stored carefully to prevent moisture uptake or degradation.

Melting point (Celsius)
194.00
Melting point (Kelvin)
467.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
258.33g/mol
Molar mass
257.3000g/mol
Density
1.2800g/cm3
Appearence

The compound typically appears as a white to off-white crystalline powder. It is not known to have any distinctive odor and is usually used in research settings.

Comment on solubility

Solubility of 1-phenyl-4-[2-(2H-tetrazol-5-yl)ethyl]piperazine

1-phenyl-4-[2-(2H-tetrazol-5-yl)ethyl]piperazine is a compound of notable interest in the field of pharmaceuticals and chemistry due to its unique structure. When discussing its solubility, several key factors and characteristics can be highlighted:

  • Solvent Compatibility: This compound exhibits variable solubility in different solvents. It is generally more soluble in polar organic solvents such as ethanol and dimethyl sulfoxide (DMSO), while its solubility in non-polar solvents like hexane tends to be low.
  • pH Dependence: The solubility might also be influenced by the pH of the solution, given the presence of the tetrazole functional group, which can affect its ionization and, subsequently, its solubility characteristics.
  • Temperature Effects: Like many organic compounds, solubility can increase with temperature; hence, conducting solubility experiments at different temperatures can be crucial for optimizing its use in applications.
  • Crystal Structure Influence: The solubility can be impacted by the crystal lattice energies, where the molecular structure can lead to varying degrees of stability which subsequently affects how easily the compound dissolves.

In summary, while 1-phenyl-4-[2-(2H-tetrazol-5-yl)ethyl]piperazine shows interesting solubility behaviors, understanding the interaction between its molecular structure and the solvent is essential for effective utilization in various applications. As one might often say, "Solubility is the key to bioavailability in pharmaceutical design." Therefore, further studies and experimentation are warranted.

Interesting facts

Exploring 1-Phenyl-4-[2-(2H-tetrazol-5-yl)ethyl]piperazine

1-Phenyl-4-[2-(2H-tetrazol-5-yl)ethyl]piperazine is a fascinating compound due to its structural complexity and potential applications in various fields. Here are some interesting facts:

  • Pharmacological Potential: This compound is notable for its potential use in pharmacology. The presence of the piperazine moiety suggests possible activity as an anti-anxiety agent or psychoactive compound.
  • Tetrazole Influence: The incorporation of the tetrazole ring is particularly intriguing. Tetrazole compounds are known for their biological activity and have been studied for their role in drug design, offering properties like enhancing solubility and bioavailability.
  • Structure-Activity Relationship: Understanding how modifications to the phenyl and piperazine structures can influence the compound's activity is essential. This is a core aspect of medicinal chemistry, helping scientists to optimize the compound for better therapeutic effects.
  • Research Focus: Various studies are ongoing to explore the effects this compound may have on neurotransmitter systems in the brain. Further research could unveil new therapeutic strategies for treating neurological disorders.
  • Versatile Applications: Besides therapeutic uses, compounds with similar structures are often investigated in the field of materials science and nanotechnology, paving new pathways for innovation.

In summary, 1-phenyl-4-[2-(2H-tetrazol-5-yl)ethyl]piperazine combines structural elegance with significant research potential, encouraging scientists to delve deeper into its many possibilities. As we continue to explore its properties and reactions, who knows what exciting applications may arise in the future?

Synonyms
Zolertine
Zolertina
Zolertinum
4004-94-8
Zolertine [INN]
Zolertinum [INN-Latin]
Zolertina [INN-Spanish]
UNII-EMD433OT6A
EMD433OT6A
1-Phenyl-4-(2-(1H-tetrazol-5-yl)ethyl)piperazine
Piperazine, 1-phenyl-4-(2-(1H-tetrazol-5-yl)ethyl)-
Zolertinum (INN-Latin)
Zolertina (INN-Spanish)
1-phenyl-4-(2-(5-tetrazolyl)ethyl)piperazine
1-phenyl-4-[2-(2H-tetrazol-5-yl)ethyl]piperazine
SCHEMBL613371
CHEMBL2111068
DTXSID70863301
XTTHMUYLNLEJRS-UHFFFAOYSA-N
NCGC00408903-01
NS00126735
5-[2-(4-PHENYL-1-PIPERAZYL)ETHYL]-TETRAZOLE
Q15634025