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1-Phenylcyclohexylamine

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Identification
Molecular formula
C12H17N
CAS number
2205-91-8
IUPAC name
1-phenylcyclohexanamine
State
State

At room temperature, 1-Phenylcyclohexylamine can be either a liquid or a solid, depending on the ambient conditions, specifically the temperature. If the temperature is above its melting point of 16 °C, it may be observed as a liquid, whereas below this temperature, it is found as a solid.

Melting point (Celsius)
16.00
Melting point (Kelvin)
289.15
Boiling point (Celsius)
285.00
Boiling point (Kelvin)
558.15
General information
Molecular weight
161.28g/mol
Molar mass
161.2750g/mol
Density
1.0057g/cm3
Appearence

1-Phenylcyclohexylamine appears as a colorless to pale yellow liquid or solid, depending on the temperature. It has a characteristic amine odor, which is often described as fishy or ammonia-like.

Comment on solubility

Solubility of 1-phenylcyclohexanamine

1-phenylcyclohexanamine, also known as phenylcylohexylamine, exhibits unique solubility characteristics that are important to consider:

  • Solvent Compatibility: It is generally soluble in organic solvents such as ethanol and chloroform, making it useful in various organic synthesis processes.
  • Water Solubility: The solubility in water is limited, which may be attributed to the hydrophobic nature of the cyclohexyl and phenyl groups.
  • Influencing Factors: Factors such as temperature and pH can significantly affect its solubility. For instance, increasing temperature often enhances solubility in organic solvents.
  • Applications: Understanding its solubility is crucial for its application in pharmaceutical formulations, where solubility in aqueous solutions is often required.

As a rule of thumb, it is essential to perform solubility tests under various conditions when working with 1-phenylcyclohexanamine to obtain specific data for your experimental needs.

Interesting facts

Exploring 1-Phenylcyclohexanamine

1-Phenylcyclohexanamine, also known as cyclohexanamine, 1-phenyl-, is an intriguing compound of considerable interest in the realm of organic chemistry.

Key Characteristics

  • Structural Diversity: This compound features a cyclohexane ring integrated with a phenyl group and an amine functional group, illustrating an interesting mix of cyclic and aromatic characteristics.
  • Applications: 1-Phenylcyclohexanamine has been investigated for its potential applications in pharmaceuticals, particularly as a building block in the synthesis of various bioactive compounds.
  • Synthetic Routes: The synthesis of 1-phenylcyclohexanamine can be achieved through several methods, including amination reactions that highlight fundamental principles of organic synthesis, making it a valuable example for students and chemists alike.

Chemical Behavior

The presence of the amine group grants this compound significant reactivity, allowing for various chemical transformations that can lead to the development of new materials or compounds.

Cultural and Historical Context

Interestingly, compounds of this type have played a role in the development of selective serotonin reuptake inhibitors (SSRIs) and other therapeutic agents, making them essential in medicinal chemistry.

Quote to Consider

As chemist Linus Pauling once said, "The best way to have a good idea is to have lots of ideas." Exploring the realm of compounds like 1-phenylcyclohexanamine exemplifies this notion, showcasing how a single structure can lead to diverse applications and innovations.

In summary, 1-phenylcyclohexanamine embodies the fascinating and complex interplay between structure and function in organic compounds, making it a worthy subject of study for both budding and experienced chemists.

Synonyms
1-PHENYLCYCLOHEXYLAMINE
2201-24-3
Cyclohexanamine, 1-phenyl-
1-phenylcyclohexan-1-amine
HBO2D49I2S
DTXSID30176449
RefChem:76987
DTXCID8098940
IEM1921
1-Phenylcyclohexanamine
1-Phenyl-cyclohexylamine
Cyclohexanamine, phenyl-
Precusor of PCP
1-AMINO-1-PHENYLCYCLOHEXANE
NCGC00247718-01
DEA No. 7460
MFCD00871835
AI3-05775
1-Phenylcyclohexanamine #
UNII-HBO2D49I2S
NCIOpen2_004407
SCHEMBL43248
SCHEMBL723224
CHEMBL253838
SCHEMBL11825356
TQP1673
AKOS009321775
DB01506
PD008819
DB-022381
NS00067963
Q27092781
1-PHENYLCYCLOHEXYLAMINE (PRECURSORS TO PHENCYCLIDINE (PCP))