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1-Phenylpiperazine

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Identification
Molecular formula
C10H14N2
CAS number
92-54-6
IUPAC name
1-phenylpiperazine
State
State

At room temperature, 1-Phenylpiperazine can be found as a liquid or crystalline solid, depending on its purity.

Melting point (Celsius)
-8.00
Melting point (Kelvin)
265.15
Boiling point (Celsius)
276.00
Boiling point (Kelvin)
549.15
General information
Molecular weight
162.24g/mol
Molar mass
162.2370g/mol
Density
1.1015g/cm3
Appearence

1-Phenylpiperazine is often found as a colorless to pale yellow liquid or in crystalline form. It can exist as a crystalline solid when purified and exhibits a distinct odor.

Comment on solubility

Solubility of 1-Phenylpiperazine

1-Phenylpiperazine, with the chemical formula C11H15N, exhibits intriguing solubility properties that are significant in its applications in medicinal chemistry and pharmacology. Here are some key points regarding its solubility:

  • Solvent Compatibility: 1-Phenylpiperazine is known to be soluble in a variety of organic solvents, including ethanol and dimethyl sulfoxide (DMSO), making it versatile for laboratory use.
  • Water Solubility: Its solubility in water is limited; however, it can still dissolve to an extent at elevated temperatures.
  • pH Influence: The solubility may vary depending on the pH of the solution. It can be expected that increased acidity enhances its solubility due to potential protonation of the nitrogen atom.
  • Hydrophobic Characteristics: Due to the presence of phenyl groups, 1-phenylpiperazine demonstrates some hydrophobic characteristics, which contribute to its lower solubility in polar solvents.

As a result, while it exhibits reasonable solubility in certain organic solvents, the challenges of its water solubility necessitate careful consideration in formulation processes particularly when dealing with biological systems. The balance between polarity and hydrophobicity is crucial for optimizing its behavior in various environments.

Interesting facts

Interesting Facts About 1-Phenylpiperazine

1-Phenylpiperazine (1-PP) is a fascinating compound that has garnered attention in both the pharmaceutical and chemical research communities. Its unique structure and properties contribute to its diverse applications across various fields. Here are some intriguing aspects of this compound:

  • Pharmacological Interest: 1-PP is often studied for its role as a serotonin receptor modulator. Given its structural similarity to other bioactive amines, it is explored for potential therapeutic applications in treating mood disorders.
  • Research Applications: The compound is utilized as a chemical probe in neuropharmacology, helping scientists understand the mechanisms of serotonin and dopamine receptors. This can lead to advancements in neuroscience and drug design.
  • Versatile Intermediary: In synthetic organic chemistry, 1-PP serves as an important precursor. It can be transformed into various derivatives, expanding its usefulness in creating complex molecules.
  • Behavioral Studies: Some studies have indicated that 1-PP can influence animal behavior, providing insights into the relationship between chemical compounds and psychoactive effects. This makes it a valuable substance for experimental psychology.
  • Stability Factor: 1-Phenylpiperazine's stability under various conditions makes it a preferred choice in synthetic reactions, which aids in the development of new pharmaceuticals.

In summary, 1-phenylpiperazine stands out for its multifaceted roles in science, from contributing to our understanding of neurotransmitter function to its potential use in drug development. As research progresses, the full scope of its capabilities may continue to unfold, piquing the interest of scientists and students alike.

Synonyms
1-PHENYLPIPERAZINE
92-54-6
Phenylpiperazine
N-Phenylpiperazine
Piperazine, 1-phenyl-
1-Phenyl-piperazine
N-Phenyldiethylenediamine
1-Fenylpiperazin
1-Fenylpiperazin [Czech]
CCRIS 4334
4-phenylpiperazine
EINECS 202-165-6
UNII-J9225CBI7D
n-phenyl piperazine
BRN 0132157
DTXSID8057855
AI3-26332
MFCD00005957
CHEMBL9434
PHENYLPIPERAZINE, 1-
J9225CBI7D
DTXCID9031644
EC 202-165-6
5-23-01-00160 (Beilstein Handbook Reference)
LEVODROPROPIZINE IMPURITY B [EP IMPURITY]
N-phenylpiperazin
LEVODROPROPIZINE IMPURITY B (EP IMPURITY)
Piperazine, 1-phenyl-, dihydrochloride
phenyl piperazine
phenyl-piperazine
4-phenylpiperazin
N-phenylpiperizine
N-phenylpyperazine
1-Phenypiperazine
1-Phenylpiperazine; N-Phenylpiperazine; NPP; Phenylpiperazine; Levodropropizine Imp. B (EP)
4-phenylpiperizine
N-phenyl piperazin
N-phenyl-piperazine
1-phenyl piperazine
4-phenyl piperazine
4-phenyl-piperazine
1-N-phenylpiperazine
N'-phenyl-piperazine
1-Phenylpiperazine, 99%
SCHEMBL24889
BIDD:GT0830
BCP22010
Tox21_113878
BBL027548
BDBM50001898
STL282711
AKOS000119106
AB00546
AC-2107
CS-W019986
FP10343
LF-0549
CAS-92-54-6
NCGC00253765-01
DB-027446
NS00004455
P0980
SR-01000944921
Q4862383
SR-01000944921-1
F2190-0343
Levodropropizine impurity B, European Pharmacopoeia (EP) Reference Standard
VU9