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1-Phenylpiperidine

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Identification
Molecular formula
C11H15N
CAS number
77-12-3
IUPAC name
1-phenylpiperidine
State
State

At room temperature, 1-Phenylpiperidine is typically found as a liquid or crystalline solid, depending on purity and storage conditions.

Melting point (Celsius)
39.00
Melting point (Kelvin)
312.15
Boiling point (Celsius)
255.00
Boiling point (Kelvin)
528.15
General information
Molecular weight
161.24g/mol
Molar mass
161.2400g/mol
Density
0.9310g/cm3
Appearence

1-Phenylpiperidine typically appears as a colorless to pale yellow liquid. It can also be found in solid form as crystalline powder.

Comment on solubility

Solubility of 1-phenylpiperidine

1-phenylpiperidine is known to have some unique solubility characteristics that are important to consider in various applications. Here are some key points:

  • Solvent Compatibility: 1-phenylpiperidine is generally soluble in organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO). This makes it useful in organic synthesis and pharmaceutical formulations.
  • Water Solubility: The compound exhibits poor solubility in water. This is crucial when considering its transport and bioavailability in biological systems.
  • Influence of Temperature: As with many organic compounds, solubility may increase with temperature. This property can be exploited during the crystallization process to obtain higher purity.
  • pH Dependence: The solubility of 1-phenylpiperidine can be influenced by the pH of the solution, particularly because it can exist in a protonated form under acidic conditions.

Overall, the solubility profile of 1-phenylpiperidine underscores the importance of choosing the right solvent and conditions for its applications, especially in drug formulation and chemical reactions. It’s always beneficial to conduct solubility tests under specific conditions to ensure desired outcomes.

Interesting facts

Interesting Facts About 1-Phenylpiperidine

1-Phenylpiperidine is a fascinating compound often studied in organic chemistry due to its unique structure and potential applications. Here are some engaging facts about this intriguing chemical:

  • Structural Diversity: The molecule consists of a piperidine ring substituted with a phenyl group. This structure contributes to its diverse chemical properties and reactivity.
  • Pharmacological Potential: 1-Phenylpiperidine has garnered interest in medicinal chemistry for its potential as a scaffold in drug development. Researchers investigate its activity as an analgesic, anti-inflammatory agent, and psychoactive compound.
  • Role in Synthesis: It serves as a versatile intermediate in the synthesis of various biologically active compounds. Chemists utilize it to create derivatives with enhanced properties.
  • Bubble Burst: Did you know that piperidine itself has a history of being used as a base in organic reactions? The addition of a phenyl group opens up even more reaction pathways!
  • Behavioral Studies: Due to its psychoactive properties, it has become a subject of behavioral studies, particularly in examining its effects on the central nervous system.

In summary, 1-phenylpiperidine is not just a molecular structure; it's a building block for new possibilities in science and pharmacology. As researchers dive deeper into its properties and applications, it promises to reveal more about the connections between structure and function in chemistry.

Synonyms
1-PHENYLPIPERIDINE
N-Phenylpiperidine
Piperidine, 1-phenyl-
EINECS 223-848-5
NSC 53427
DTXSID4063294
DTXCID7039838
223-848-5
inchi=1/c11h15n/c1-3-7-11(8-4-1)12-9-5-2-6-10-12/h1,3-4,7-8h,2,5-6,9-10h
llskxgrdupmxlc-uhfffaoysa-n
4096-20-2
1-Phenyl-piperidine
phenylpiperidine
MFCD00129777
phenylpiperadine
N-phenylpiperdine
N-phenyl-piperidine
NSC53427
1-phenyl piperidine
N-(phenyl)piperidine
SCHEMBL93630
CHEMBL4439365
AC7935
NSC-53427
AKOS005146029
FS-5253
AC-20742
FP148660
SY051417
CS-0156104
NS00030887
P2159