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Amphetamine

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Identification
Molecular formula
C9H13N
CAS number
300-62-9
IUPAC name
1-phenylpropan-1-amine
State
State

Amphetamine is generally found as a solid at room temperature, particularly when synthesized in the form of a sulfate salt or hydrochloride salt. In its freebase form, it is a liquid.

Melting point (Celsius)
11.30
Melting point (Kelvin)
284.45
Boiling point (Celsius)
203.00
Boiling point (Kelvin)
476.15
General information
Molecular weight
135.21g/mol
Molar mass
135.2060g/mol
Density
0.9360g/cm3
Appearence

Amphetamine typically appears as a colorless liquid or a white crystalline powder. The appearance may vary based on purification and the preparation process.

Comment on solubility

Solubility of 1-phenylpropan-1-amine

1-phenylpropan-1-amine, also known as phenylpropan-1-amine, displays notable solubility characteristics that are essential for its chemical behavior and applications. Its solubility can be summarized as follows:

  • Solvent Compatibility: This compound is generally soluble in polar solvents such as water and alcohols, due to the presence of its amine functional group.
  • Temperature Influence: The solubility tends to increase with temperature, a common phenomenon seen with many organic compounds.
  • Hydrophobic Interactions: The phenyl ring provides some hydrophobic character which can impact its solubility in non-polar solvents. Hence, the solubility in non-polar solvents like hexane is low.

It is important to note that pH levels can also influence the solubility of amines. In acidic conditions, 1-phenylpropan-1-amine can exist in its protonated form, enhancing its solubility in water. As a rule of thumb, when thinking about solubility:

  1. **For polar solvents:** Soluble.
  2. **For non-polar solvents:** Insoluble.
  3. **In acidic solutions:** Increased solubility due to protonation.

Overall, understanding the solubility of 1-phenylpropan-1-amine is crucial for its application in synthetic chemistry and pharmaceuticals where its solubility profile governs reactivity and integration into various formulations.

Interesting facts

Interesting Facts About 1-Phenylpropan-1-amine

1-Phenylpropan-1-amine, commonly known as phenylpropanamine, is a fascinating compound in the realm of organic chemistry. Here are some intriguing aspects of this compound:

  • Applications in Medicine: This compound has garnered attention in medicinal chemistry due to its potential therapeutic applications, especially in the treatment of conditions like ADHD.
  • Sympathetic Stimulation: As an α-aminopropylphenylamine, it acts as a stimulant, engaging the sympathetic nervous system, similar to how certain popular amphetamines function.
  • Synthesis: 1-Phenylpropan-1-amine can be synthesized through various methods, including reductive amination processes, which highlight the beauty and intricacies of organic synthesis.
  • Chemical Structure: The presence of a phenyl group attached to a propan-1-amine backbone creates unique steric and electronic conditions that influence its reactivity and interactions. This makes it an interesting target for chemical modifications.
  • Sensitivity to Regulation: Due to its potential use in illicit drug synthesis, compounds like 1-phenylpropan-1-amine face strict regulations in many countries, emphasizing the importance of ethical considerations in research.

In summary, 1-phenylpropan-1-amine serves as a prime example of how a single chemical compound can play diverse roles in science, from therapeutic efficacy to regulatory challenges. As a branch of study, understanding such compounds opens avenues for innovation in both chemistry and healthcare.

Synonyms
1-phenylpropan-1-amine
2941-20-0
1-Phenylpropylamine
1-phenyl-1-propanamine
CHEBI:153571
DTXSID30859841
DTXCID50210379
608-356-4
alpha-Ethylbenzylamine
1-Phenyl-propylamine
a-ethylbenzylamine
alpha-Ethylbenzenemethanamine
alpha-Phenylpropylamine
35600-74-9
MFCD00038169
(S)-alpha-ethylbenzylamine
BENZYLAMINE, alpha-ETHYL-
Phenylpropan-1-Amine
1-phenyl-propyl-amine
alpha -ethylbenzylamine
(s)-a-ethylbenzylamine
1-(phenyl)-propylamine
(RS)-1-phenylpropylamine
EC 608-356-4
benzene, (1-aminopropyl)-
1-Phenyl-2-methylethylamine
SCHEMBL43945
alpha-Ethylbenzylamine, 97%
Benzenemethanamine, .alpha.-ethyl
ALBB-001474
STR04886
STK400150
AKOS000123098
AKOS017258862
AB91926
SB44721
SB45120
SY080814
DB-022454
DB-047912
CS-0204798
NS00002444
EN300-34041
F78690
A819886
Z1262252904
(R)-2-Phenyl-1-propylamine;(R)-(+)-beta-Methylphenethylamine