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Tacrine

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Identification
Molecular formula
C13H14N2
CAS number
321-64-2
IUPAC name
1-piperidyl(1,2,3,4-tetrahydroacridin-9-yl)methanone
State
State

At room temperature, Tacrine is in a solid state and comes in a powder form.

Melting point (Celsius)
194.00
Melting point (Kelvin)
467.15
Boiling point (Celsius)
518.20
Boiling point (Kelvin)
791.35
General information
Molecular weight
198.27g/mol
Molar mass
198.2730g/mol
Density
1.3140g/cm3
Appearence

Tacrine is typically a white to off-white crystalline powder.

Comment on solubility

Solubility of 1-piperidyl(1,2,3,4-tetrahydroacridin-9-yl)methanone

The solubility of 1-piperidyl(1,2,3,4-tetrahydroacridin-9-yl)methanone is a critical parameter to consider in both computational and experimental chemistry. This compound is organic and has attributes that influence its solubility profile. Some key factors include:

  • Polar nature: Given the presence of nitrogen in the piperidine structure, this compound exhibits polar characteristics, which can enhance its interaction with polar solvents.
  • Hydrophobic regions: The tetrahydroacridine structure introduces hydrophobic characteristics, which may limit solubility in highly polar solvents.
  • Functional groups: The presence of a carbonyl group (part of the methanone functionality) tends to increase solubility in polar solvents due to its ability to engage in hydrogen bonding.

Experimental findings show that the solubility of this compound is likely to vary significantly between solvents. For instance:

  • Solubility in water: It may exhibit limited solubility due to the presence of hydrophobic regions within the molecular structure.
  • Solubility in organic solvents: It is expected to dissolve more readily in non-polar to slightly polar organic solvents such as ethanol or acetone.

In conclusion, while the solubility of 1-piperidyl(1,2,3,4-tetrahydroacridin-9-yl)methanone can be influenced by various factors including polarity, functional groups, and solvent interactions, experimental validation is essential for precise solubility data. Understanding these interactions can greatly assist in applications ranging from drug formulation to material science.

Interesting facts

Interesting Facts About 1-Piperidyl(1,2,3,4-tetrahydroacridin-9-yl)methanone

1-Piperidyl(1,2,3,4-tetrahydroacridin-9-yl)methanone is a compound that has attracted attention for its potential applications in the fields of medicinal chemistry and neuroscience. Here are some fascinating insights:

  • Novel Structure: This compound features a unique fusion of a piperidine ring and a tetrahydroacridine moiety, making it an interesting candidate for exploring structure-activity relationships.
  • Potential Therapeutic Uses: Researchers are investigating its implications as a pharmacological agent. Its structure suggests possible effects on neurotransmitter systems, particularly in relation to acetylcholine and dopamine, which can be crucial in treating cognitive disorders.
  • Neuroprotective Properties: Compounds related to tetrahydroacridine are often studied for neuroprotective effects. This compound may exhibit such properties and is being evaluated for its potential in neurodegenerative diseases.
  • Research Interest: Due to its complex structure, scientists are conducting synthetic studies to develop analogs that can enhance its bioactivity and selectivity, aiming for lower side effects in therapeutic applications.
  • Medicinal Chemistry: As a promising lead compound, it serves as a blueprint for developing new drugs targeting cognitive impairments and other neurological disorders.

In conclusion, 1-piperidyl(1,2,3,4-tetrahydroacridin-9-yl)methanone is more than just a compound; it represents a growing field of research aimed at unlocking novel treatments for complex brain disorders. As a scientist or chemistry student, it’s exciting to see how compounds like this shape the future of drug discovery and development.

Synonyms
BRN 0419592
KETONE, PIPERIDINO(1,2,3,4-TETRAHYDRO-9-ACRIDINYL)
7101-58-8
4-(1-Piperidyl)carbonyl-2,3-tetramethylenequinoline
Acridine, 1,2,3,4-tetrahydro-9-(piperidinocarbonyl)-
DTXSID70221240
5-22-03-00350 (Beilstein Handbook Reference)
DTXCID70143731
piperidin-1-yl(1,2,3,4-tetrahydroacridin-9-yl)methanone
HMS1770M12
AKOS001453099
Z27689054
PIPERIDINO(1,2,3,4-TETRAHYDRO-9-ACRIDINYL)METHANONE