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Nadolol

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Identification
Molecular formula
C17H27NO3
CAS number
42200-33-9
IUPAC name
1-(tert-butylamino)-3-(1-naphthyl)propan-2-ol
State
State

At room temperature, nadolol is in a solid state.

Melting point (Celsius)
128.00
Melting point (Kelvin)
401.00
Boiling point (Celsius)
570.85
Boiling point (Kelvin)
843.85
General information
Molecular weight
309.44g/mol
Molar mass
309.4420g/mol
Density
1.1380g/cm3
Appearence

Nadolol is a white crystalline powder. It is slightly soluble in water and alcohols, providing solutions that are slightly alkaline.

Comment on solubility

Solubility Characteristics of 1-(tert-butylamino)-3-(1-naphthyl)propan-2-ol

The compound 1-(tert-butylamino)-3-(1-naphthyl)propan-2-ol exhibits unique solubility properties that are influenced by its organic structure and functional groups. Understanding its solubility is essential for applications in medicinal chemistry and other fields.

Solubility Overview:

This compound's solubility can be characterized by the following points:

  • Polar vs. Nonpolar: Due to the presence of a tert-butylamino group, the compound is relatively polar. However, the naphthyl component adds a significant hydrophobic character.
  • Solvent Compatibility: It is more soluble in organic solvents such as ethanol and dimethyl sulfoxide (DMSO), while exhibiting lower solubility in water.
  • Impact of pH: The solubility can be affected by the pH of the solution. In acidic conditions, protonation of the amine group may enhance solubility in aqueous media.

Overall, the solubility of 1-(tert-butylamino)-3-(1-naphthyl)propan-2-ol is a balance between its polar and nonpolar aspects, making it important for researchers to consider the environment and solvents used in their studies.

Interesting facts

Interesting Facts about 1-(tert-butylamino)-3-(1-naphthyl)propan-2-ol

1-(tert-butylamino)-3-(1-naphthyl)propan-2-ol is a fascinating compound known for its unique properties and applications. Here are some noteworthy facts:

  • Structure and Features: The compound features a chiral center, making it optically active. This characteristic allows for the possibility of two enantiomers, which can exhibit different biological activities.
  • Pharmacological Influence: This compound is often studied in pharmacology due to its interaction with certain receptors in the body. Its structure can influence its ability to act as a ligand, making it a subject of interest for developing new medications.
  • Solubility Characteristics: While we will not delve into specific solubility data, the bulky tert-butyl group often contributes to hydrophobic interactions, which can affect how the compound behaves in various solvents and biological systems.
  • Research Applications: Compounds such as 1-(tert-butylamino)-3-(1-naphthyl)propan-2-ol are valuable in the study of biochemical pathways and drug design, as they can serve as models for active pharmaceutical ingredients.
  • Historical Context: The exploration of similar naphthyl derivatives has roots in organic chemistry and medicinal chemistry, as researchers have sought to uncover structures that lead to improved efficacy and reduced side effects in therapeutic contexts.

In summary, 1-(tert-butylamino)-3-(1-naphthyl)propan-2-ol is more than just a chemical compound; it represents a blend of structural complexity and functional potential that continues to inspire research and innovation in the field of chemistry.

Synonyms
AKOS015327921