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Salbutamol Hydrochloride

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Identification
Molecular formula
C13H21ClN2O3
CAS number
51022-70-9
IUPAC name
1-(tert-butylamino)-3-(2-chloro-5-methyl-phenoxy)propan-2-ol;hydrochloride
State
State

Salbutamol Hydrochloride is typically a solid at room temperature, appearing as a crystalline powder.

Melting point (Celsius)
153.00
Melting point (Kelvin)
426.15
Boiling point (Celsius)
331.70
Boiling point (Kelvin)
604.85
General information
Molecular weight
288.81g/mol
Molar mass
288.8120g/mol
Density
1.2400g/cm3
Appearence

Salbutamol Hydrochloride appears as a white or almost white powder. It is freely soluble in water and ethanol, and its solutions in water are usually clear.

Comment on solubility

Solubility of 1-(tert-butylamino)-3-(2-chloro-5-methyl-phenoxy)propan-2-ol Hydrochloride

The solubility of 1-(tert-butylamino)-3-(2-chloro-5-methyl-phenoxy)propan-2-ol; hydrochloride can be assessed through several factors:

  • Ionic Nature: As a hydrochloride salt, it is expected to be soluble in polar solvents such as water. The presence of the hydrochloride group introduces ionic interactions that can enhance solubility.
  • Hydrogen Bonding: The compound potentially forms hydrogen bonds with water due to the hydroxyl (-OH) group present. This can further contribute to its solubility.
  • Alkyl Chain Influence: The tert-butylamine segment may impact solubility. Although it is generally less polar, its bulky nature can introduce steric factors that influence how well the compound interacts with solvents.
  • Temperature Dependency: As with many compounds, solubility is likely to increase with temperature. This means that higher temperatures may facilitate better solvation in a given solvent.

In summary, this specific hydrochloride compound is anticipated to exhibit good solubility in aqueous solutions, primarily due to its ionic characteristic and potential for hydrogen bonding. Careful consideration of the solvent’s properties and environmental conditions will be crucial for optimal solubility.

Interesting facts

Interesting Facts about 1-(tert-butylamino)-3-(2-chloro-5-methyl-phenoxy)propan-2-ol hydrochloride

This compound, known as 1-(tert-butylamino)-3-(2-chloro-5-methyl-phenoxy)propan-2-ol hydrochloride, belongs to a class of substances that are particularly remarkable due to their roles in medicinal chemistry. Here are some key points that make this compound intriguing:

  • Pharmacological Significance: This compound has been studied for its potential applications in treating various medical conditions, showcasing the importance of amines in drug design.
  • Chiral Center: The propanol part of the structure contains a chiral carbon, leading to distinct enantiomers. This offers researchers avenues for exploring how each enantiomer may exhibit different biological activities.
  • Substituent Diversity: The incorporation of a chloro group and a methyl group on the phenoxy ring creates variability in molecular interactions, making it valuable in the post-synthesis modification of drug analogs.
  • Environmental and Safety Considerations: Like many synthesized compounds, the environmental impact and safety profile should be closely monitored, especially given its potential pharmaceutical use.
  • Future Research: There is ongoing research focused on optimizing its effectiveness and minimizing side effects, which is a critical aspect of pharmaceutical development.

As a scientist or student, understanding the intricate details of compounds like this can illustrate the delicate balance between chemical structure and biological function. Engaging with *cutting-edge research* in this area not only deepens your knowledge but can also lead to significant contributions in the pharmaceutical industry.


In summary, 1-(tert-butylamino)-3-(2-chloro-5-methyl-phenoxy)propan-2-ol hydrochloride is an excellent example of how diverse chemical structures can lead to a wealth of applications and insights in chemistry.

Synonyms
bupranolol hydrochloride
Betadrenol
Bupranolol HCl
15148-80-8
Betadran
Looser
Panimit
Bupranolol hydrochloride [JAN]
B 1312
3-(tert-Butylamino)-1-[(6-chloro-m-tolyl)oxy]propan-2-ol hydrochloride
DTC2G3GDPL
Bupranolol (hydrochloride)
1-(tert-butylamino)-3-(2-chloro-5-methylphenoxy)propan-2-ol hydrochloride
15148-80-8 (HCl)
1-(tert-butylamino)-3-(2-chloro-5-methylphenoxy)propan-2-ol;hydrochloride
23284-25-5
dl-Bupranolol hydrochloride
Betadrenol hydrochloride
SKF 16805A
UNII-DTC2G3GDPL
EINECS 239-208-3
dl-KL 255
(+-)-Kl 255
1-(tert-Butylamino)-3-(2-chloro-5-methylphenoxy)-2-propanol hydrochloride
SCHEMBL348360
orb1738974
Bupranolol hydrochloride (JP17)
CHEBI:31323
DTXSID50904544
YAA28425
BUPRANOLOL HYDROCHLORIDE [MI]
KL-255
3-tert-Butylamino-1-(6-chloro-3-methylphenoxy)propan-2-ol hydrochloride
BUPRANOLOL HYDROCHLORIDE [MART.]
BUPRANOLOL HYDROCHLORIDE [WHO-DD]
NS00085118
B-1312
D01454
Q27276590
2-Propanol, 1-tert-butylamino-3-(6-chloro-m-tolyloxy)-, hydrochloride
1-(TERT-BUTYLAMINO)-3-((6-CHLORO-M-TOLYL)-OXY)-2-PROPANOL HYDROCHLORIDE