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Methdilazine

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Identification
Molecular formula
C18H22N2S
CAS number
1982-37-2
IUPAC name
10-[(1-methyl-3-piperidyl)methyl]phenothiazine
State
State

At room temperature, Methdilazine is generally found in a solid state, typically as a crystalline powder.

Melting point (Celsius)
85.00
Melting point (Kelvin)
358.15
Boiling point (Celsius)
484.80
Boiling point (Kelvin)
757.95
General information
Molecular weight
282.45g/mol
Molar mass
282.4280g/mol
Density
1.1980g/cm3
Appearence

Methdilazine typically appears as a white or slightly yellow crystalline solid.

Comment on solubility

Solubility of 10-[(1-methyl-3-piperidyl)methyl]phenothiazine (C18H22N2S)

10-[(1-methyl-3-piperidyl)methyl]phenothiazine exhibits intriguing solubility characteristics that are essential for its applications in various fields. Understanding the solubility of this compound helps predict its behavior in different environments and formulations. Here are some key points:

  • Solvent Dependence: The solubility of C18H22N2S can vary significantly depending on the solvent used. It is generally more soluble in organic solvents such as ethanol and DMSO compared to water.
  • Temperature Influence: Increasing the temperature typically enhances solubility, making it a crucial factor during the preparatory processes or when formulating drugs.
  • Hydrophilic vs. Hydrophobic Balance: The presence of the piperidine moiety contributes to a moderate hydrophilic nature, while the phenothiazine backbone adds hydrophobic characteristics, leading to ambivalent solubility behavior.
  • pH Sensitivity: The solubility can also be pH-sensitive, with potential variations in protonation states affecting dissolution in aqueous solutions.

In conclusion, the solubility profile of 10-[(1-methyl-3-piperidyl)methyl]phenothiazine is crucial for its pharmacological effectiveness and must be carefully considered in formulation strategies. Further studies on ionic strength and complexation might offer additional insights into its solubility dynamics.

Interesting facts

Exploring 10-[(1-methyl-3-piperidyl)methyl]phenothiazine

10-[(1-methyl-3-piperidyl)methyl]phenothiazine is a complex compound that serves an important role in medicinal chemistry, particularly in the development of antipsychotic medications. This compound belongs to the phenothiazine class, a group well-known for its diverse pharmacological properties. Here are some engaging facts about this intriguing chemical:

  • Therapeutic Applications: Phenothiazines are primarily used to treat schizophrenia and other psychiatric disorders. They act by antagonizing dopamine receptors in the brain, helping to alleviate symptoms of psychosis.
  • Molecular Structure: The unique structure of 10-[(1-methyl-3-piperidyl)methyl]phenothiazine allows for a specific interaction with various neurotransmitter systems, including serotonin and norepinephrine.
  • History: The discovery of phenothiazines dates back to the 1950s and marked a significant milestone in the development of antipsychotic medications. It was a breakthrough for patients suffering from mental illnesses.
  • Synergistic Effects: Researchers are continuously studying how modifying different groups in compounds similar to this can lead to improved efficacy and reduced side effects, maximizing therapeutic benefits.

As a chemical scientist or student, understanding this molecule not only expands your knowledge of pharmacologically active compounds but also underlines the significance of chemical modifications in enhancing drug design.

With ongoing studies around 10-[(1-methyl-3-piperidyl)methyl]phenothiazine, the future holds promises for more effective treatments that can improve the quality of life for many individuals affected by mental health disorders.

Synonyms
Pecazine
MEPAZINE
60-89-9
Nothiazine
Pacatal
Meprazine
Mepazin
Paxital
Pecatal
Mepazine Base
Lacumin
Pakatal
Pacatal Base
mepasin
Pecazina
Mesapin
MPMP
Pacatol
Pecazinum
Pecazine [INN:BAN]
Pecazinum [INN-Latin]
Pecazina [INN-Spanish]
(N-Methyl-3-piperidyl)methylphenothiazine
10-[(1-methylpiperidin-3-yl)methyl]phenothiazine
10H-Phenothiazine, 10-((1-methyl-3-piperidinyl)methyl)-
P 391
EINECS 200-490-8
10-(1-Methylpiperidyl-3-methyl)phenothiazine
DTXSID2046177
UNII-PH34873A38
AI3-50131
III-2318
MEPAZINE [MI]
PECAZINE [INN]
10-(1-Methyl-3-piperidyl)methyl phenothiazine
10-((1-Methyl-3-piperidyl)methyl)phenothiazine
PECAZINE [WHO-DD]
PH34873A38
Phenothiazine, 10-((1-methyl-3-piperidyl)methyl)-
10H-Phenothiazine, 10-[(1-methyl-3-piperidinyl)methyl]-
DTXCID0026177
10-[(1-Methyl-3-piperidyl)methyl]phenothiazine
NCGC00160480-01
Pecazinum (INN-Latin)
Pecazina (INN-Spanish)
P-391
Phenothiazine, 10-[(1-methyl-3-piperidyl)methyl]-
pecazin
10-((1-METHYL-3-PIPERIDINYL)METHYL)-10H-PHENOTHIAZINE
BDBM50177661
10-((1-methylpiperidin-3-yl)methyl)phenothiazine
10-[(1-Methyl-3-piperidinyl)methyl]-10H-phenothiazine
Mepazine?
Pecazine HCl
Probes1_000237
Probes2_000278
NCIOpen2_008134
Oprea1_067080
Oprea1_208564
US9504692, Mepezine
CBDivE_007551
MLS006011657
SCHEMBL149976
CHEMBL395110
GTPL9782
CHEBI:135324
AAA06089
Tox21_111842
STK386548
AKOS000280691
AKOS021820849
CCG-108581
FP30405
CAS-60-89-9
DA-75417
MS-24522
SMR004703409
HY-121282
CS-0081367
G12767
AB00275848-07
10-[(1-Methyl-3-piperidyl)-methyl]-phenothiazin
phenothiazine, 10-[3-(N-methyl)piperidinyl]methyl-
BRD-A82772293-001-01-6
BRD-A82772293-001-03-2
Q27286554
10-[(1-methylpiperidin-3-yl)methyl]-10H-phenothiazine
10-[(1-Methyl-3-piperidinyl)methyl]-10H-phenothiazine #
10-[(1-METHYL-3-PIPERIDYL)METHYL]-10H-PHENOTHIAZINE
200-490-8