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Promethazine hydrochloride

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Identification
Molecular formula
C17H21N2S · HCl
CAS number
58-33-3
IUPAC name
10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine;hydrochloride
State
State

At room temperature, promethazine hydrochloride is a solid.

Melting point (Celsius)
223.00
Melting point (Kelvin)
496.15
Boiling point (Celsius)
275.00
Boiling point (Kelvin)
548.15
General information
Molecular weight
320.88g/mol
Molar mass
320.8820g/mol
Density
1.4210g/cm3
Appearence

Promethazine hydrochloride typically appears as a white to faintly yellow crystalline powder. It is sensitive to light, which may cause discoloration when exposed for long periods.

Comment on solubility

Solubility of 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine hydrochloride

The solubility characteristics of 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine hydrochloride are essential for its biological applications and pharmacological efficacy. Several factors influence its solubility:

  • Nature of the compound: Being a hydrochloride salt enhances its solubility in water, as the ionic bond typically improves the solubility properties compared to its free base form.
  • Polarity: The presence of both hydrophilic (due to the hydrochloride) and hydrophobic moieties (from the phenothiazine structure) gives rise to a unique solubility profile.
  • Solvent considerations: Polar solvents such as water or ethanol tend to dissolve the compound more effectively while nonpolar solvents may result in low solubility.

It is often noted that, as a rule, “like dissolves like,” meaning that this compound is more likely to be soluble in polar solvents due to its ionic character. However, specific solubility values can vary depending on concentration, temperature, and the presence of other substances.

In summary, the solubility of 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine hydrochloride represents a balance influenced by various chemical properties and environmental factors, underscoring its relevance in both research and practical applications.

Interesting facts

Interesting Facts about 10-[(1-Methylpyrrolidin-3-yl)methyl]phenothiazine Hydrochloride

10-[(1-Methylpyrrolidin-3-yl)methyl]phenothiazine hydrochloride is a fascinating compound known for its role in medicinal chemistry and neuroscience. As a derivative of phenothiazine, it exhibits properties that make it significant in pharmacology.

Key Features

  • Pharmacological Significance: This compound is primarily recognized for its therapeutic potential in treating various psychiatric disorders such as schizophrenia and bipolar disorder. Its structure allows it to interact effectively with the central nervous system.
  • Mechanism of Action: By blocking dopaminergic receptors—primarily D2 receptors—this compound can help in alleviating symptoms of psychosis, emphasizing the importance of receptor interaction in drug efficacy.
  • Synthetic Versatility: The synthesis of 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine hydrochloride allows for modifications that can tailor its activity or improve its pharmacokinetic properties.

The compound's interaction with various neurotransmitter systems adds to its complexity. According to a study, compounds in this class can have multiple receptor targets, which can lead to broader therapeutic effects or unwanted side effects.

Research and Applications

This compound is not just a subject of theoretical study; it is actively researched for its potential applications in:

  • Neuropharmacology
  • Psychoactive medication development
  • Understanding biochemical pathways involved in mood regulation

With ongoing research and exploration in the field of medicinal chemistry, the significance of 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine hydrochloride continues to grow, paving the way for advancements in treatment strategies for complex mental health disorders. The ongoing studies will undoubtedly reveal more about its precise effects and potential applications.

Synonyms
METHDILAZINE HYDROCHLORIDE
1229-35-2
Methdilazine Hcl
Bristaline
Disyncran
Tacaryl hydrochloride
Methdilazine monohydrochloride
CCRIS 6256
NSC 169091
MJ 5022
HSDB 5192
UNII-T0GSO02UEZ
T0GSO02UEZ
EINECS 214-967-3
NSC-169091
DTXSID3025548
10-(1-Methyl-3-pyrroldiylmethyl)phenothiazine hydrochloride
DTXCID905548
Methdilazine hydrochloride (USP)
Methdilazine hydrochloride [USP]
10-((1-Methyl-3-pyrrolidinyl)methyl)phenothiazine, hydrochloride
CHEBI:140855
Phenothiazine, 10-((1-methyl-3-pyrrolidinyl)methyl)-, hydrochloride
Phenothiazine, 10-((1-methyl-3-pyrrolidinyl)methyl)-, monohydrochloride
10H-Phenothiazine, 10-((1-methyl-3-pyrrolidinyl)methyl)-, monohydrochloride
10-[(1-Methyl-3-pyrrolidinyl)methyl]phenothiazine hydrochloride
METHDILAZINE HYDROCHLORIDE (MART.)
METHDILAZINE HYDROCHLORIDE [MART.]
METHDILAZINE HYDROCHLORIDE (USP-RS)
METHDILAZINE HYDROCHLORIDE [USP-RS]
METHDILAZINE HYDROCHLORIDE (USP IMPURITY)
METHDILAZINE HYDROCHLORIDE [USP IMPURITY]
10-((1-methyl-3-pyrrolidinyl)methyl)phenothiazine hydrochloride
10-((1-methylpyrrolidin-3-yl)methyl)-10H-phenothiazine hydrochloride (1:1)
10-[(1-methylpyrrolidin-3-yl)methyl]-10H-phenothiazine hydrochloride (1:1)
DILOSYM
(+-)-METHDILAZINE HYDROCHLORIDE
METHDILAZINE HYDROCHLORIDE, (+-)-
10-((1-Methyl-3-pyrrolidinyl)methyl)-10H-phenothiazine Hydrochloride
10-((1-METHYL-3-PYRROLIDINYL)METHYL)-PHENOTHIAZINE, HYDROCHLORIDE
214-967-3
10-((1-Methylpyrrolidin-3-yl)methyl)-10H-phenothiazine hydrochloride
Methdilazine (hydrochloride)
Dilosyn; Disyncran
10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine;hydrochloride
1229-35-2 (HCl)
10H-Phenothiazine, 10-[(1-methyl-3-pyrrolidinyl)methyl]-, hydrochloride (1:1)
10-[(1-methylpyrrolidin-3-yl)methyl]-10H-phenothiazine hydrochloride
NSC169091
C18H21ClN2S
Methilazine hydrochloride
Tacaryl hydrochloride (TN)
SCHEMBL211226
CHEMBL1200532
HY-B1690A
Tox21_110047
AKOS016014016
METHDILAZINE HYDROCHLORIDE [MI]
METHDILAZINE HYDROCHLORIDE [HSDB]
NCGC00014482-01
(+/-)-METHDILAZINE HYDROCHLORIDE
DA-65365
METHDILAZINE HYDROCHLORIDE [VANDF]
CAS-1229-35-2
METHDILAZINE HYDROCHLORIDE [WHO-DD]
CS-0013674
METHDILAZINE HYDROCHLORIDE, (+/-)-
NS00081198
D04980
METHDILAZINE HYDROCHLORIDE [ORANGE BOOK]
WLN: T C666 BN ISJ B1- CT5NTJ A1 &GH
Q27289510
10-[(1-methylpyrrolidin-1-ium-3-yl)methyl]phenothiazine;chloride