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Thioridazine

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Identification
Molecular formula
C21H26N2O2S2
CAS number
50-52-2
IUPAC name
10-[2-(1-methyl-2-piperidyl)ethyl]-2-methylsulfonyl-phenothiazine
State
State

At room temperature, thioridazine is a solid.

Melting point (Celsius)
168.00
Melting point (Kelvin)
441.15
Boiling point (Celsius)
545.00
Boiling point (Kelvin)
818.15
General information
Molecular weight
370.57g/mol
Molar mass
370.5670g/mol
Density
1.3725g/cm3
Appearence

Thioridazine typically appears as a white or slightly yellow crystalline powder.

Comment on solubility

Solubility of 10-[2-(1-methyl-2-piperidyl)ethyl]-2-methylsulfonyl-phenothiazine

The solubility of 10-[2-(1-methyl-2-piperidyl)ethyl]-2-methylsulfonyl-phenothiazine is a fascinating subject due to its specific chemical structure and properties. Understanding its solubility can provide insights into its potential applications and behavior in different environments.

Key Points to Consider:

  • Polarity: The presence of the sulfonyl group in the compound contributes to its polar nature, which may enhance solubility in polar solvents.
  • Solvent Compatibility: This compound is likely to have varied solubility in different solvents, with better solubility in organic solvents compared to water due to its complex structure.
  • Hydrogen Bonding: The ability of the compound to form hydrogen bonds may also affect its solubility, particularly in more protic solvents.
  • Temperature Effects: Solubility is temperature-dependent; increasing temperature typically increases the solubility of solid compounds.
  • pH Considerations: The solubility can vary depending on the pH of the environment, particularly if acidic or basic conditions affect ionization.

In summary, while detailed empirical data on the solubility of 10-[2-(1-methyl-2-piperidyl)ethyl]-2-methylsulfonyl-phenothiazine is essential for practical applications, its solubility characteristics will be influenced by several factors including polarity, solvent choice, and environmental conditions. Understanding these traits can lead to optimal usage in pharmaceutical and chemical contexts.

Interesting facts

Interesting Facts About 10-[2-(1-methyl-2-piperidyl)ethyl]-2-methylsulfonyl-phenothiazine

This fascinating compound, known for its complex structure, belongs to a class of medicinal agents that have been extensively studied for their therapeutic potential. Here are some noteworthy points:

  • Pharmacological Relevance: The compound is related to phenothiazine derivatives, which are well-known for their antipsychotic and antihistaminic properties. These compounds are commonly used in the treatment of various psychiatric disorders.
  • Intriguing Structure: The incorporation of a methyl-2-piperidyl group enhances its lipophilicity, potentially affecting its ability to cross the blood-brain barrier, which is crucial for central nervous system (CNS) activity.
  • Mechanism of Action: Like other phenothiazines, this compound may act as an antagonist at dopamine receptors. Its unique substitutions might confer specific effects or side effects that are of great interest in ongoing research.
  • Potential Research Applications: The compound’s unique functional groups make it a prime candidate for study in drug development and chemical biology, particularly in the search for novel treatments for mental health conditions.
  • Synthetic Challenges: The synthesis of such multi-substituted phenothiazines often requires sophisticated synthetic strategies, making them an interesting target for organic chemists looking to employ innovative reactions and approaches.

In conclusion, 10-[2-(1-methyl-2-piperidyl)ethyl]-2-methylsulfonyl-phenothiazine stands as a testament to the rich tapestry of medicinal chemistry, highlighting the intricate relationships between structure and activity that are foundational to drug discovery.

Synonyms
Sulforidazine
Imagotan
Psychoson
Inofal
14759-06-9
Thioridazine-2-sulfone
Sulforidazina
TPN-12
Solforidazina
Sulforidazinum
Thioridazine sulfone
Thioridazine sulphone
10-(2-(1-Methyl-2-piperidyl)ethyl)-2-methylsulfonylphenothiazine
B7599I244X
10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfonylphenothiazine
10-(2-(1-methylpiperidin-2-yl)ethyl)-2-methylsulfonylphenothiazine
2-methanesulfonyl-10-(2-(1-methylpiperidin-2-yl)ethyl)-10H-phenothiazine
2-METHANESULFONYL-10-[2-(1-METHYLPIPERIDIN-2-YL)ETHYL]-10H-PHENOTHIAZINE
RefChem:932382
238-818-7
Thioridazine 2-Sulfone
10H-Phenothiazine, 10-[2-(1-methyl-2-piperidinyl)ethyl]-2-(methylsulfonyl)-
Phenothiazine, 10-(2-(1-methyl-2-piperidyl)ethyl)-2-methylsulfonyl-
Solforidazina [DCIT]
TPN 12
Sulforidazine [INN:DCF]
10H-Phenothiazine, 10-(2-(1-methyl-2-piperidinyl)ethyl)-2-(methylsulfonyl)-
Sulforidazinum [INN-Latin]
Sulforidazina [INN-Spanish]
EINECS 238-818-7
BRN 1230366
2-Methylsulfonyl-10-[2-(1-methyl-2-piperidyl)ethyl]phenothiazine
(+/-)-Thioridazine-2-sulfone
2-METHYLSULFONYL-10-(2-(1-METHYL-2-PIPERIDYL)ETHYL)PHENOTHIAZINE
UNII-B7599I244X
2-Methylsulfonyl-10-(2-(1-methyl-2-piperidyl)ethyl)phenothiazin
SULFORIDAZINE [MI]
SULFORIDAZINE [INN]
SCHEMBL145025
SULFORIDAZINE [MART.]
SULFORIDAZINE [WHO-DD]
CHEMBL2107268
SCHEMBL29598204
BDBM86723
DTXSID30864531
CHEBI:135644
MFCD00867758
NSC_31765
AKOS030239787
CAS_14759-06-9
NS00015416
THIORIDAZINE IMPURITY E [EP IMPURITY]
L000789
Q7636215
THIORIDAZINE HYDROCHLORIDE IMPURITY E [EP IMPURITY]
10-[2-(1-Methyl-2-piperidinyl)ethyl]-2-methylsulfonylphenothiazine
10-[2-(1-methyl-2-piperidyl)ethyl]-2-methylsulfonyl-phenothiazine
10-(2-(1-METHYL-2-PIPERIDINYL)ETHYL)-2-(METHYLSULFONYL)-10H-PHENOTHIAZINE
10-[2-(1-Methyl-2-piperidinyl)ethyl]-2-(methylsulfonyl)-10H-phenothiazine #
PHENOTHIAZINE, 10-(2-(1-METHYL-2-PIPERIDYL)ETHYL)-2-(METHYLSULFONYL)-