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Methylene Blue

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Identification
Molecular formula
C16H18N3SCl
CAS number
7220-79-3
IUPAC name
10-[2-(dimethylamino)propyl]-N,N-dimethyl-phenothiazine-2-sulfonamide;methanesulfonic acid
State
State

At room temperature, methylene blue is typically found as a solid. It is often used in powder form or dissolved in a liquid for applications where its coloring properties are needed.

Melting point (Celsius)
100.00
Melting point (Kelvin)
373.15
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.15
General information
Molecular weight
373.90g/mol
Molar mass
373.9000g/mol
Density
1.2780g/cm3
Appearence

Methylene blue is a dark green solid at room temperature. It is commonly encountered as a powder. When dissolved in water, it generates a deep blue solution. The intensity of the blue color depends on the concentration of the solution.

Comment on solubility

Solubility of 10-[2-(dimethylamino)propyl]-N,N-dimethyl-phenothiazine-2-sulfonamide; methanesulfonic acid

The solubility of 10-[2-(dimethylamino)propyl]-N,N-dimethyl-phenothiazine-2-sulfonamide; methanesulfonic acid can be influenced by various factors unique to its molecular structure. Key aspects include:

  • Polarity: This compound possesses both hydrophobic (non-polar) and hydrophilic (polar) portions, which can significantly affect its solubility in different solvents.
  • Temperature: As with many organic compounds, solubility may increase with temperature. This is an important consideration when preparing solutions for chemical reactions or analyses.
  • pH Levels: The presence of the sulfonamide and methanesulfonic acid groups suggests that alterations in pH could enhance or reduce solubility due to ionization of functional groups.
  • Solvent Type: This compound is likely to have different solubility characteristics in polar solvents (like water) versus non-polar solvents (like hexane).

In general, compounds with both sulfonamide and amine functional groups tend to exhibit good solubility in polar solvents, while their presence in non-polar solvents may be limited. As a result, one might anticipate that this compound will show favorable solubility in aqueous environments, depending significantly on the solvent composition and conditions.


In conclusion, for practical applications, experimental determination of solubility under various conditions is essential for accurate assessment and utilization of the compound in various fields, including pharmaceuticals and materials science.

Interesting facts

Interesting Facts about 10-[2-(dimethylamino)propyl]-N,N-dimethyl-phenothiazine-2-sulfonamide; methanesulfonic acid

This complex compound, known for its unique structure and properties, has garnered attention in various fields of research, especially in medicinal chemistry. Here are some fascinating insights:

  • Pharmacological Uses: The compound is part of the phenothiazine family, which has been extensively studied for its therapeutic effects. Many derivatives of phenothiazines are used as antipsychotic medications, showcasing the importance of this class in psychiatry.
  • Dimethylamino Group: The presence of dimethylamino groups in the structure has significant implications for the compound’s biological activity. These groups can enhance lipophilicity and improve the interaction with biological membranes, potentially increasing its effectiveness as a therapeutic agent.
  • Surfactant Qualities: Some studies suggest that compounds like this one exhibit surfactant properties, making them useful in formulations where solubility and stability of drugs are vital.
  • Potential in Research: The compound is a subject of ongoing research for its potential applications in neurochemistry and cancer therapies, indicating a frontline role in the development of new medicinal agents.
  • Mechanism of Action: Understanding the mechanism of action of phenothiazine derivatives can lead to the development of more targeted therapies. Research indicates that this compound may act on various neurotransmitter systems, suggesting complex pharmacodynamics.

In summary, 10-[2-(dimethylamino)propyl]-N,N-dimethyl-phenothiazine-2-sulfonamide; methanesulfonic acid illustrates the crossroads of medicinal chemistry and pharmacology, where the design and modification of chemical compounds can lead to significant advancements in treatment options for various disorders. Its intricate structure, versatile applications, and ongoing research make it a compelling subject for chemists and pharmacologists alike.

Synonyms
FONAZINE MESYLATE
Neomestine
Calsekin
Promaquid
Yoristen
Bonpac
Dimethothiazine mesylate
Banistyl
IL-6302 mesylate
13115-40-7
Fonazine methanesulfonate
dimetotiazine mesilate
Migristne
Fonazine mesilate
Fonazine mesylate [USAN]
10-[2-(dimethylamino)propyl]-N,N-dimethyl-10H-phenothiazine-2-sulphonamide monomethanesulphonate
Il-6302 mesilate
8599 R.P. MESYLATE
Dimethothiazine mesilate
8599 r.p. mesilate
B28V86NGNK
Dimetotiazine mesilate [JAN]
10-[2-(dimethylamino)propyl]-N,N-dimethylphenothiazine-2-sulfonamide;methanesulfonic acid
10H-Phenothiazine-2-sulfonamide, 10-(2-(dimethylamino)propyl)-N,N-dimethyl-, monomethanesulfonate
Fonazine mesylate (USAN)
Dimetotiazine mesilate (JAN)
8599RP mesylate
RP 8599 mesylate
10-(2-(Dimethylamino)propyl)-N,N-dimethyl-10H-phenothiazine-2-sulphonamide monomethanesulphonate
Dimethothiazine methanesulfonate
EINECS 236-041-8
UNII-B28V86NGNK
Banistyl (TN)
7455-39-2
10-(2-(Dimethylamino)propyl)-N,N-dimethylphenothiazine-2-sulfonamide methanesulfonate
SCHEMBL121515
CHEMBL2104669
CHEBI:31499
DTXSID10927092
JGKVKXPDDVRUKC-UHFFFAOYSA-N
GLXC-10519
FONAZINE METHANESULFONATE [MI]
DIMETOTIAZINE MESILATE [MART.]
DIMETOTIAZINE MESILATE [WHO-DD]
Phenothiazine-2-sulfonamide, 10-(2-(dimethylamino)propyl)-N,N-dimethyl-, monomethanesulfonate
NS00085323
D01902
Q5277354
10-[2-(Dimethylamino)propyl]-N,N-dimethylphenothiazine-2-sulfonamide monomethanesulfonate
10-(2-(DIMETHYLAMINO)PROPYL)-N,N-DIMETHYLPHENOTHIAZINE-2-SULPHONAMIDE MONOMETHANESULPHONATE
10H-PHENOTHIAZINE-2-SULPHONAMIDE, 10-(2-(DIMETHYLAMINO)PROPYL)-N,N-DIMETHYL-, MONOMETHANESULPHONATE
Methanesulfonic acid--10-[2-(dimethylamino)propyl]-N,N-dimethyl-10H-phenothiazine-2-sulfonamide (1/1)