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Ethopropazine

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Identification
Molecular formula
C19H22N2S
CAS number
493-24-1
IUPAC name
10-(2-pyrrolidin-1-ylethyl)phenothiazine
State
State

At room temperature, ethopropazine is typically found in a crystalline solid form.

Melting point (Celsius)
98.00
Melting point (Kelvin)
371.15
Boiling point (Celsius)
451.50
Boiling point (Kelvin)
724.60
General information
Molecular weight
310.46g/mol
Molar mass
310.4610g/mol
Density
1.2270g/cm3
Appearence

Ethopropazine is a pale yellow to amber crystalline powder.

Comment on solubility

Solubility of 10-(2-pyrrolidin-1-ylethyl)phenothiazine

The solubility of 10-(2-pyrrolidin-1-ylethyl)phenothiazine can be influenced by various factors due to its complex structure. Here are some key points to consider:

  • Polarity: The presence of the pyrrolidinyl group introduces polar functional characteristics, which may enhance solubility in polar solvents.
  • Solvent Compatibility: Solubility might be high in solvents such as:
    • Dimethyl sulfoxide (DMSO)
    • Alcohols (e.g., ethanol, methanol)
    • Aqueous solutions under certain conditions
  • Temperature Dependency: Generally, an increase in temperature can lead to increased solubility for many organic compounds. Therefore, solubility should be explored at varying temperatures.
  • Chemical Interactions: The ability to form hydrogen bonds can also impact solubility. The interaction of the compound with solvation shells in a solvent may enhance its dissolution.

In summary, while the overall solubility of 10-(2-pyrrolidin-1-ylethyl)phenothiazine can vary significantly depending on the solvent and conditions, it is likely to exhibit better solubility in polar environments due to the structural characteristics imparted by the pyrrolidinyl moiety. Further empirical studies are encouraged to measure the exact solubility parameters.

Interesting facts

Interesting Facts about 10-(2-pyrrolidin-1-ylethyl)phenothiazine

10-(2-pyrrolidin-1-ylethyl)phenothiazine is a fascinating compound that draws interest due to its unique structure and potential applications in various fields. Here are some intriguing aspects of this compound:

  • Structural Diversity: The presence of a phenothiazine moiety combined with a pyrrolidine substituent offers a diverse range of chemical reactivity. This structural complexity is often associated with enhanced pharmacological activity.
  • Pharmacological Relevance: Compounds related to phenothiazines have a well-documented history in medicinal chemistry, particularly as antipsychotic agents. Research suggests that this specific compound may exhibit similar biological activities, expanding its potential use in psychopharmacology.
  • Research Implications: Studies involving 10-(2-pyrrolidin-1-ylethyl)phenothiazine can provide insights into the mechanism of action of phenothiazines and their derivatives, contributing to the development of novel therapeutic agents with improved efficacy and reduced side effects.
  • Interdisciplinary Interest: This compound sparks interest not only in chemistry but also in fields such as biology and pharmacology. The interplay between chemical structure and biological activity highlights the importance of interdisciplinary research.
  • Synthetic Pathways: The synthesis of this compound can serve as a valuable educational example for students exploring organic synthesis techniques, particularly those focusing on heterocyclic compounds.

In summary, 10-(2-pyrrolidin-1-ylethyl)phenothiazine is more than just a chemical formula; it represents a bridge between chemistry and medicine, showcasing the intricate relationships that exist within the realm of chemical compounds.

Synonyms
Pyrathiazine
Parathiazine
84-08-2
Pyrathiazinum
Paratiazina
Parathiazinum
10-(2-(1-Pyrrolidyl)ethyl)phenothiazine
Parathiazinum [INN-Latin]
Paratiazina [INN-Spanish]
Parathiazine [INN]
Pyrathiazine [INN]
Pyrrolidino-aethyl-phenthiazin
10-(2-(1-Pyrrolidinyl)ethyl)phenothiazine
N-(beta-Pyrrolidinoethyl)phenothiazine
Pyrrolidine, 1-(2-phenothiazin-10-ylethyl)-
Pyrrolidino-aethyl-phenthiazin [German]
DTXSID2046252
2305SQ56Z2
PARATHIAZINE [WHO-DD]
DTXCID0026252
Phenothiazine, 10-(2-(1-pyrrolidinyl)ethyl)-
Parathiazinum (INN-Latin)
Paratiazina (INN-Spanish)
10-[2-(1-Pyrrolidinyl)ethyl]-10H-phenothiazine
10-[2-(1-Pyrrolidinyl)ethyl]phenothiazine
Phenothiazine, 10-[2-(1-pyrrolidinyl)ethyl]-
10-(2-(1-Pyrrolidinyl)ethyl)-10H-phenothiazine
635-914-4
10-(2-pyrrolidin-1-ylethyl)phenothiazine
10-(2-(Pyrrolidin-1-yl)ethyl)-10H-phenothiazine
NCGC00160599-01
10H-Phenothiazine, 10-[2-(1-pyrrolidinyl)ethyl]-
UNII-2305SQ56Z2
Parathiazine (DCI)
Rolazote (Salt/Mix)
Pyrrolazote (Salt/Mix)
Pyrrolazoate (Salt/Mix)
NCIOpen2_008241
Oprea1_320249
Parathiazine (pharmaceutical)
SCHEMBL2110244
CHEMBL1887666
BDBM81472
CHEBI:135253
KJKJUXGEMYCCJN-UHFFFAOYSA-N
Tox21_111927
CAS_10646
NSC_10646
PDSP1_000148
PDSP2_000147
AKOS024338465
CAS-84-08-2
N-(.beta.-Pyrrolidinoethyl)phenothiazine
phenothiazine, 10-(N-pyrrolidinyl)ethyl-
phenothiazine, 10-(2-pyrrolidinylethyl)-
NS00114092
SR-01000945030
10-[2-(1-Pyrrolidinyl)ethyl]-10H-phenothiazine #
SR-01000945030-1
Pyrrolidine, 1-[2-(10H-phenothiazin-10-yl)ethyl]-
Q27253692