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Flumazenil

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Identification
Molecular formula
C15H14ClFN4O3
CAS number
78755-81-4
IUPAC name
10-chloro-11b-(2-fluorophenyl)-7-(2-hydroxyethyl)-3,5-dihydro-2H-oxazolo[3,2-d][1,4]benzodiazepin-6-one
State
State

At room temperature, Flumazenil is a solid.

Melting point (Celsius)
199.00
Melting point (Kelvin)
472.15
Boiling point (Celsius)
390.00
Boiling point (Kelvin)
663.15
General information
Molecular weight
303.75g/mol
Molar mass
303.7360g/mol
Density
1.2800g/cm3
Appearence

Flumazenil is typically a white to off-white crystalline powder.

Comment on solubility

Solubility of 10-chloro-11b-(2-fluorophenyl)-7-(2-hydroxyethyl)-3,5-dihydro-2H-oxazolo[3,2-d][1,4]benzodiazepin-6-one

The solubility of a compound can significantly influence its bioavailability and therapeutic effectiveness. In the case of 10-chloro-11b-(2-fluorophenyl)-7-(2-hydroxyethyl)-3,5-dihydro-2H-oxazolo[3,2-d][1,4]benzodiazepin-6-one (C15H14ClFN4O3), several factors determine its solubility profile.

Key considerations include:

  • Polarity: The presence of polar functional groups, such as -OH and -Cl, suggests some level of solubility in polar solvents.
  • Hydrogen Bonding: The -OH group may allow for hydrogen bonding, enhancing solubility in aqueous environments.
  • Molecular Weight: Its relatively moderate molecular weight can facilitate interactions with solvents, impacting solubility.
  • Solvent Interaction: The choice of solvent (water, ethanol, dimethyl sulfoxide) can drastically change solubility parameters.

While specific solubility data is not widely reported for this compound, one might expect some degree of solubility in polar solvents due to its structural features. However, it is essential to conduct empirical tests to determine its exact solubility behavior.

In conclusion, understanding the solubility characteristics of 10-chloro-11b-(2-fluorophenyl)-7-(2-hydroxyethyl)-3,5-dihydro-2H-oxazolo[3,2-d][1,4]benzodiazepin-6-one requires consideration of its chemical structure and interactions, emphasizing the importance of solvent choice in practical applications.

Interesting facts

Exploring 10-chloro-11b-(2-fluorophenyl)-7-(2-hydroxyethyl)-3,5-dihydro-2H-oxazolo[3,2-d][1,4]benzodiazepin-6-one

This compound belongs to a fascinating class of chemicals known as benzodiazepines, which are primarily recognized for their impact on the central nervous system. Benzodiazepines are often utilized for their therapeutic effects, including anxiolytic (anti-anxiety), sedative, and anticonvulsant properties. Here are some fascinating aspects of this particular compound:

  • Structural Complexity: The molecular structure is characterized by the presence of an oxazolo[3,2-d][1,4]benzodiazepine framework, which features a unique blend of both aromatic and heterocyclic elements. This structural diversity contributes to its potential biological activity.
  • Chlorine and Fluorine Substituents: The presence of chlorine and fluorine atoms in the molecule can significantly alter its chemical properties. These halogens are known for their electronegative nature, influencing the compound's reactivity and interaction with biological systems.
  • Hydroxyl Group: The 2-hydroxyethyl substituent adds another layer of complexity to the compound, potentially enhancing its solubility and biological interactions in aqueous environments.
  • Potential Applications: Due to its structural characteristics, this compound may exhibit significant pharmacological activity, making it a candidate for further research in drug development, particularly in fields related to neurology and psychiatry.

In the words of a seasoned chemist, “The intricacies in synthesis and the resulting biological properties of benzodiazepines are often a testament to the elegance of medicinal chemistry.” Today's ongoing research could unveil new therapeutic agents based on compounds like this, underscoring the importance of understanding their chemistry deeply.

Thus, the study of 10-chloro-11b-(2-fluorophenyl)-7-(2-hydroxyethyl)-3,5-dihydro-2H-oxazolo[3,2-d][1,4]benzodiazepin-6-one not only highlights its individual merits but also its potential as a valuable tool in the expansion of medicinal chemistry and drug design.

Synonyms
flutazolam
27060-91-9
Coreminal
5G2K7O5D8S
10-chloro-11b-(2-fluorophenyl)-7-(2-hydroxyethyl)-3,5-dihydro-2H-[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6-one
10-Chloro-11b-(o-fluorophenyl)-2,3,7,11b-tetrahydro-7-(2-hydroxyethyl)oxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one
Flutazolamum
Flutazolam [INN:JAN]
Flutazolamum [INN-Latin]
MS-4101
BRN 1092501
UNII-5G2K7O5D8S
Coreminal (TN)
10-Chloro-11b-(2-fluorophenyl)-2,3,7,11b-tetrahydro-7-(2-hydroxyethyl)oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one; Coreminal; Flutazolam; MS 4101; Ro 7-6102; 10-Chloro-11b-(o-fluorophenyl)-2,3,7,11b-tetrahydro-7-(2-hydroxyethyl)-oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one
10-chloro-11b-(2-fluorophenyl)-7-(2-hydroxyethyl)-2,3,5,11b-tetrahydrooxazolo(3,2-d) [1,4]benzodiazepin-6(7H)-one
10-chloro-11b-(2-fluorophenyl)-7-(2-hydroxyethyl)-2,3,5,11b-tetrahydrooxazolo(3,2-d)[1,4]benzodiazepin-6(7H)-one
10-chloro-11b-(2-fluorophenyl)-7-(2-hydroxyethyl)-2,3,5,11b-tetrahydrooxazolo[3,2-d] [1,4]benzodiazepin-6(7H)-one
10-Chloro-11b-(2-fluorophenyl)-7-(2-hydroxyethyl)-2,3,5,11b-tetrahydrooxazolo[3,2-d][1,4]benzodiazepin-6(7H)-one
FLUTAZOLAM [MI]
Flutazolam (JAN/INN)
FLUTAZOLAM [INN]
FLUTAZOLAM [JAN]
FLUTAZOLAM [MART.]
FLUTAZOLAM [WHO-DD]
10-Chloro-11b-(2-fluorophenyl)-2,3,7,11b-tetrahydro-7-(2-hydroxyethyl)oxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one
SCHEMBL546958
CHEMBL1697836
DTXSID6023072
CHEBI:31628
WMFSSTNVXWNLKI-UHFFFAOYSA-N
GLXC-10548
CBA06091
AKOS040748369
Flutazolam (1.0mg/ml in Acetonitrile)
DA-73413
Oxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one, 10-chloro-11b-(o-fluorophenyl)-2,3,7,11b-tetrahydro-7-(2-hydroxyethyl)-
HY-111481
CS-0042166
D01286
Q5462935
10-chloro-11b-(2-fluorophenyl)-7-(2-hydroxyethyl)-2,3,5,11b-tetrahydrooxazolo(3,2-d)[ 1,4]benzodiazepin-6(7H)-one
10-chloro-11b-(2-fluorophenyl)-7-(2-hydroxyethyl)-2,3,7,11b-tetrahydro[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one