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Amitifadine

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Identification
Molecular formula
C20H25NO
CAS number
446050-35-9
IUPAC name
10-(cyclopropylmethyl)-1,13-dimethyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol
State
State

At room temperature, Amitifadine is in a solid state, typically presented as a powder for ease of use in laboratory settings or pharmaceutical formulations.

Melting point (Celsius)
121.00
Melting point (Kelvin)
394.15
Boiling point (Celsius)
275.00
Boiling point (Kelvin)
548.15
General information
Molecular weight
311.43g/mol
Molar mass
311.4320g/mol
Density
1.2300g/cm3
Appearence

Amitifadine is a crystalline solid that appears as a white to off-white powder. The compound's structure is complex, with both aromatic and aliphatic characteristics due to its unique tricyclic form. It is often handled in its solid state and appears as fine granules or a powder.

Comment on solubility

Solubility of 10-(cyclopropylmethyl)-1,13-dimethyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol

The solubility of the compound 10-(cyclopropylmethyl)-1,13-dimethyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol is influenced by its unique molecular structure and functional groups. Understanding the solubility characteristics of this compound is crucial for its applications in various fields. Here are some key points to consider:

  • Polarity: The presence of hydroxyl groups can increase the polarity of the compound, making it more soluble in polar solvents like water.
  • Hydrophobic Interactions: The cyclopropylmethyl group adds hydrophobic character, which might limit solubility in polar solvents but enhance solubility in nonpolar solvents.
  • Hydrogen Bonding: The ability of the -OH group to form hydrogen bonds can enhance solubility in protic solvents, allowing for better interaction with solvent molecules.
  • pH Dependence: The solubility of this compound may vary with changes in pH, as ionization can affect the degree of solubility in different environments.

Overall, while predicting the solubility behavior of complex organic compounds like 10-(cyclopropylmethyl)-1,13-dimethyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol can be challenging, it is often a balance of hydrophilic and hydrophobic properties that ultimately determines solubility in a given solvent. Increasing the understanding of these interactions can lead to better applications and utilization of such compounds in various chemical processes.

Interesting facts

Interesting Facts About 10-(Cyclopropylmethyl)-1,13-dimethyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol

The compound 10-(cyclopropylmethyl)-1,13-dimethyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol is a fascinating example of a complex organic molecule, showcasing the incredible potential of chemical structures in medicinal chemistry and materials science. Here are some intriguing aspects of this compound:

  • Diverse Applications: Due to its unique framework, this compound has potential applications in various fields including pharmaceuticals, where it can act as a building block for drug synthesis.
  • Cyclopropylmethyl Group: The presence of the cyclopropylmethyl group in its structure contributes to its unique chemical reactivity and properties, allowing for interesting interactions with biological targets.
  • Drug-like Properties: Compounds with similar structures are often evaluated for their biological activity, particularly in the development of new treatments for various diseases, making this compound a candidate worth studying.
  • Structural Complexity: The tricyclic framework adds a layer of complexity, making it a subject of interest in stereochemistry and conformational studies, vital for understanding its behavior in different environments.
  • Natural Occurrence: Compounds of this nature can sometimes be found in nature or can be synthesized to mimic naturally occurring molecules, showcasing how chemistry can bridge the gap between nature and synthetic design.

Additionally, chemists are often captivated by how structural modifications in such complex compounds can lead to significantly different biological activities. As quoted by one prominent chemist, "The beauty of chemistry lies in the intricate dance of atoms and molecules, where a single change can lead to groundbreaking discoveries." The exploration of compounds like 10-(cyclopropylmethyl)-1,13-dimethyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol highlights the endless possibilities within the realm of synthetic organic chemistry.

Synonyms
CYCLAZOCINE
3572-80-3
NIH 7981
Ciclazocina
Cyclazocinum
UM 407
WIN 20740
NSC-107429
WIN 20,740
Cyclazocine [USAN:INN]
Cyclazocinum [INN-Latin]
Ciclazocina [INN-Spanish]
2,6-Methano-3-benzazocin-8-ol, 3-(cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-
EINECS 222-689-9
NSC 107429
2-Cyclopropylmethyl-2'-hydroxy-5,9-dimethyl-6,7-benzomorphan
J5W1B1159C
CYCLAZOCINE [MI]
3-(Cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-2,6-methano-3-benzazocin-8-ol
2-Cyclopropylmethyl-5,9-dimethyl-2'-hydroxy-6,7-benzomorphan
CYCLAZOCINE [INN]
NSC107429
CYCLAZOCINE [USAN]
3-Cyclopropylmethyl-6(eq),11(ax)-dimethyl-2,6-methano-3-benzazocin-8-ol
DTXSID9022863
WIN-20740
2,6-Methano-3-benzazocin-8-ol, 1,2,3,4,5,6-hexahydro-3-(cyclopropylmethyl)-6,11-dimethyl-
Cyclazocinum (INN-Latin)
Ciclazocina (INN-Spanish)
DTXCID802863
222-689-9
yqyvfvrqlzmjkj-uhfffaoysa-n
MLS002703971
10-(cyclopropylmethyl)-1,13-dimethyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol
Cyclazocine (+)
CYCLAZOCINE (-)
7346-09-0
UNII-J5W1B1159C
Rac-Cyclazocine
EINECS 230-866-7
(+/-)-Cyclazocine
Cyclazocine (USAN/INN)
SCHEMBL37996
CHEMBL289683
cyclopropylmethyl(dimethyl)[?]ol
3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol
(cyclazocine)2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid
10-cyclopropylmethyl-1,13-dimethyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol(Cyclazocine)
2,6-Methano-3-benzazocin-8-ol,3-(cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-,(2S,6S,11S)-
3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol (cyclazocine)
3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol(Cyclazocine)
BDBM50018731
NSC172134
2-Cyclopropylmethyl-5,7-beneomorphan
NSC-172134
(2alpha,6alpha,11R*)-(1)-3-(Cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-2,6-methano-3-benzazocin-8-ol
SMR001395644
NS00029907
NS00080844
D03618
2-Cyclopropylmethyl-2'-hydroxy-5,7-benzomorphan
L001209
Q5198126
WLN: T C666 A KN&TTJ A1 B1 EQ K1- AL3TJ
3-Cyclopropylmethyl-6[eq],6-methano-3-benzazocin-8-ol
2-Cyclopropylmethyl-5,9-dimethyl-2'-hydroxy-6,7-beneomorphan
2, 1,2,3,4,5,6-hexahydro-3-(cyclopropylmethyl)-6,11-dimethyl-
2, 3-(cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-
{3-Cyclopropylmethyl-6[eq],} {11[ax]-dimethyl-2,6-methano-3-benzazocin-8-ol}
3-(Cyclopropylmethyl)-1,3,4,5,6-hexahydro-6,11-dimethyl-2,6-methano-3-benzazocin-8-ol
3-(cyclopropylmethyl)-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-8-ol
3-(Cyclopropylmethyl)1-1,3,4,5,6-hexahydro-6,11-dimethyl-2,6-methano-3-benzazocin-8-ol
(Cyclazocine) 3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol
2, 3-(cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-, (2.alpha.,6.alpha.,11R*)-
2, 6-Methano-3-benzazocin-8-ol, 1,2,3,4,5, 6-hexahydro-3-(cyclopropylmethyl)-6,11-dimethyl-
2, 6-Methano-3-benzazocin-8-ol, 3-(cyclopropylmethyl)-1,2,3,4,5, 6-hexahydro-6,11-dimethyl-
2,6-Methano-3-benzazocin-8-ol, 3-(cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-; Cyclazocine; NSC 107429; Win 20740
3-(Cyclopropylmethyl)-1,2,3, 4,5,6-hexahydro-6,11-dimethyl-2,6-methano-3-benzazocin-8-ol
3-(Cyclopropylmethyl)1-1,2,3,4,5,6-hexahydro-6,11-dimethyl-2, 6-methano-3-benzazocin-8-ol