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Mitoxantrone

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Identification
Molecular formula
C22H28N4O6
CAS number
65271-80-9
IUPAC name
10-hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one
State
State

The compound is a solid at room temperature.

Melting point (Celsius)
238.00
Melting point (Kelvin)
511.20
Boiling point (Celsius)
228.50
Boiling point (Kelvin)
501.70
General information
Molecular weight
518.43g/mol
Molar mass
518.4310g/mol
Density
1.3400g/cm3
Appearence

Mitoxantrone typically appears as a dark blue crystalline solid. It is commonly used in a medical context, where it is provided as a solution for injection, and these solutions are usually dark blue colored.

Comment on solubility

Solubility of 10-hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one

The solubility of 10-hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one is a complex characteristic, influenced by its molecular structure and functional groups. Understanding its solubility can provide valuable insights into its behavior in various environments. Here are some key points regarding its solubility:

  • Polarity: The presence of hydroxyl (-OH) and methoxy (-OCH3) groups increases the polarity of the compound, suggesting it might have greater solubility in polar solvents like water.
  • Hydrophobic regions: The hydrophobic benzoheptalene structure can hinder solubility in aqueous solutions, potentially limiting its dispersion in water.
  • Solvent Interaction: The solubility may vary significantly depending on the choice of solvent, with organic solvents such as ethanol or dimethyl sulfoxide (DMSO) potentially providing better solubility profiles.
  • Temperature effects: Solubility often increases with temperature, which could be beneficial for applications that require dissolution.

In summary, while the polarity-enhancing groups suggest favorable interactions with polar solvents, the compound's complex structure also dictates a nuanced solubility behavior, typically requiring organic solvents for optimal dissolution. Further empirical testing would yield more definitive insights into its solubility characteristics.

Interesting facts

Interesting Facts about 10-Hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one

This fascinating compound is at the intersection of organic chemistry and pharmacology, showcasing the intricate beauty of molecular structures and their potential applications. Its unique structure contributes to various interesting attributes:

  • Complexity of Structure: The compound features multiple functional groups, including hydroxyl, methoxy, and methylamino moieties, which can significantly influence its chemical reactivity and biological activity.
  • Potential Medicinal Use: Compounds like this one are often explored for their pharmacological properties, which may include anti-inflammatory, analgesic, or neuroprotective effects. Research into such compounds can contribute to drug discovery efforts.
  • Natural Occurrence: It’s worth noting that some related structures are found in nature, often derived from plants, and may play a role in traditional medicine.
  • Analytical Methods: The analysis and characterization of such complex molecules often require advanced techniques, such as NMR spectroscopy, mass spectrometry, and chromatography, making it a subject of interest in analytical chemistry.

Overall, the study of 10-hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one offers a glimpse into the broader world of organic compounds and their diverse applications in science and medicine. As researchers delve deeper into its properties, they may unveil further secrets that could lead to new treatments and advancements in chemistry.

Synonyms
Demecolceine
COLCHICEINE, N-DEACETYL-N-METHYL-
NSC 36559
518-11-6
Colchiceine, N-desacetyl-N-methyl-
10-hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one
Colchiceine, 7-deacetamido-7-(methylamino)-
DTXSID50199731
(7S)-1,2,3-trimethoxy-7-(methylazaniumyl)-9-oxo-6,7-dihydro-5H-benzo(a)heptalen-10-olate
(7S)-1,2,3-trimethoxy-7-(methylazaniumyl)-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-10-olate
10-hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydro-5H-benzo(a)heptalen-9-one
DTXCID10122222
(7s)-10-hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydro-5h-benzo(a)heptalen-9-one
atwwygqdygswqa-uhfffaoysa-n
Colchameine
Benzo(a)heptalen-9(5H)-one, 6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-7-(methylamino)-, (S)-
(7s)-9-hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-10(5h)-one
10-Hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one #