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Glycyrrhetinic acid

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Identification
Molecular formula
C30H46O4
CAS number
471-53-4
IUPAC name
10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid
State
State
At room temperature, glycyrrhetinic acid is a solid substance.
Melting point (Celsius)
315.00
Melting point (Kelvin)
588.15
Boiling point (Celsius)
444.00
Boiling point (Kelvin)
717.15
General information
Molecular weight
470.70g/mol
Molar mass
470.7030g/mol
Density
1.1600g/cm3
Appearence

Glycyrrhetinic acid is a white to off-white crystalline powder. It is known for its characteristic potential to form a shiny crystalline structure under appropriate conditions.

Comment on solubility

Solubility of 10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid (C30H46O4)

The solubility of 10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid is influenced by several factors, primarily due to its complex molecular structure. Its solubility characteristics can be summarized as follows:

  • Polarity: The presence of multiple hydroxy groups indicates some degree of polarity, which can enhance solubility in polar solvents such as water to some extent.
  • Hydrophobic Regions: Given the large hydrocarbon structure with multiple methyl groups, the compound also exhibits hydrophobic properties. This typically leads to reduced solubility in water.
  • Solvent Interactions: The solubility will vary significantly depending on the solvent used. For example, it may be more soluble in organic solvents like chloroform or ethanol due to its hydrophobic characteristics.
  • Acidic Nature: Being a carboxylic acid, it may ionize in basic conditions, potentially increasing solubility in aqueous solutions under certain pH conditions.

In conclusion, while this compound may have some degree of solubility in both polar and non-polar solvents, the balance between its hydrophilic and hydrophobic characteristics renders it less soluble in water. As one insightfully notes, “Understanding the solubility of such complex molecules requires a depth of consideration regarding their structural nuances.”

Interesting facts

Interesting Facts about 10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid

This fascinating compound, known for its complex structure and biological significance, is a noteworthy subject of study in the realm of organic chemistry. Here are some captivating insights about this molecule:

  • Complexity of Structure: With a highly intricate polycyclic framework, this compound showcases the beauty of organic structures. The presence of multiple rings and functional groups adds to its uniqueness and potential applications.

  • Biological Relevance: Compounds like this one are often investigated for their biological activities. Researchers are particularly interested in their potential roles in pharmaceutical development, possibly influencing various biological pathways.

  • Synthesis Challenges: The synthesis of such complex organic molecules can pose significant challenges, often requiring innovative methodologies and techniques in organic synthesis.

  • Applications in Research: This compound might be of interest in fields like drug discovery and development, where understanding its interactions with biological systems can lead to new therapeutic agents.

  • Structures and Derivatives: The study of this compound can lead to discovering derivatives with modified properties, enhancing their potential usage in various fields, including materials science and nanotechnology.

As a scientist or student diving into the world of organic chemistry, it is essential to recognize the significance that complex compounds such as this hold in advancing our scientific knowledge and applications. *"The beauty of chemistry lies in its complexity and potential, where each compound tells its own story."*

Synonyms
enoxolone
Uralenic acid
GLYCYRRHETINIC ACID
Glycyrrhetin
Biosone
3-Hydroxy-11-oxoolean-12-en-29-oic acid
3-Glycyrrhetinic acid
.alpha.-Glycyrrhetinic acid
18.beta.-Glycyrrhetic acid
18.beta.-Glycyrrhtinic acid
18.beta.-Glycyrrhetinic acid
NSC35347
NSC35350
1449-05-4
Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3.beta.,20.beta.)-
Arthrodont
3.beta.-Hydroxy-11-oxoolean-12-en-30-oic acid
Olean-12-en-30-oic acid, 3.beta.-hydroxy-11-oxo-
18a-glycyrrhetinic acid
NSC-35350
Glyccyrhetic acid
NCGC00181115-01
.beta.-Glycyrrhetic acid
.beta.-Glycyrrhetinic acid
SCHEMBL25465
10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid
18-.beta.-Glycrrhetinic acid
18.alpha.-Glycyrrhetinic acid
Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3beta,20beta)-
18-.beta.-Glycyrrhetinic acid
CHEMBL1863561
Glycyrrhetinic acid, 18 alpha-
DTXSID50859383
MPDGHEJMBKOTSU-UHFFFAOYSA-N
BBL009942
GLYCYRRHETINIC ACID,18 ALPHA
STK801355
AKOS005612983
P.O. 12
NCI60_003170
VS-02260
DB-042758
Olean-12-en-29-oic acid, (3.beta.,20.beta.)-
3.beta.-Hydroxy-11-oxo-18.alpha.-olean-12-en-30-oic acid
Olean-12-en-29-oic acid, (3.beta.,18.alpha.,20.beta.)-
(3.beta.,20.beta.)-3-Hydroxy-11-oxoolean-12-en-29-oic acid
18.alpha.-olean-12-en-30-oic acid, 3.beta.-hydroxy-11-oxo-
3-Hydroxy-11-oxoolean-12-en-29-oic acid, (3.beta.,20.beta.)- #
WLN: L F6 E6 B666 CV DUTJ A1 HVQ H1 K1 N1 O1 S1 S1 TQ -.alpha.
WLN: L F6 E6 B666 CV DUTJ A1 HVQ H1 K1 N1 O1 S1 S1 TQ -BETA
10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid