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Physostigmine

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Identification
Molecular formula
C15H21N3O2
CAS number
57-47-6
IUPAC name
(10-oxo-8-azatricyclo[5.3.1.03,8]undecan-5-yl) 1H-indole-3-carboxylate
State
State

Physostigmine is typically a solid at room temperature.

Melting point (Celsius)
105.00
Melting point (Kelvin)
378.15
Boiling point (Celsius)
572.00
Boiling point (Kelvin)
845.15
General information
Molecular weight
275.35g/mol
Molar mass
275.3260g/mol
Density
1.4000g/cm3
Appearence

Physostigmine is a crystalline solid that appears as white or yellowish crystals.

Comment on solubility

Solubility Insights for (10-oxo-8-azatricyclo[5.3.1.03,8]undecan-5-yl) 1H-indole-3-carboxylate

The solubility of the compound (10-oxo-8-azatricyclo[5.3.1.03,8]undecan-5-yl) 1H-indole-3-carboxylate, with the chemical formula C15H21N3O2, can be influenced by various factors due to its intricate structure. The presence of multiple functional groups and the overall geometry plays a critical role in determining its solubility characteristics. Here are some key points to consider:

  • Polarity: The presence of carboxylate groups typically enhances solubility in polar solvents, while a larger hydrophobic portion can decrease it.
  • Solvent Interaction: This compound may dissolve better in organic solvents such as ethanol or acetone compared to water due to the hydrophobic nature of portions of its structure.
  • Temperature Dependence: Solubility can vary significantly with temperature; generally, increased temperatures can enhance solubility for many organic compounds.
  • Hydrogen Bonding: Compounds with the ability to form inter- or intramolecular hydrogen bonds may have altered solubility characteristics as well.

As a result, its solubility behavior could be summarized as follows: "The compound is expected to exhibit a moderate to low solubility profile in aqueous environments while potentially showing improved solubility in various organic solvents." Understanding these nuances is essential for applications where this compound may be utilized.

Interesting facts

Interesting Facts About (10-oxo-8-azatricyclo[5.3.1.03,8]undecan-5-yl) 1H-indole-3-carboxylate

(10-oxo-8-azatricyclo[5.3.1.03,8]undecan-5-yl) 1H-indole-3-carboxylate is a fascinating compound that sits at the intersection of organic chemistry and medicinal research. The unique structural characteristics of this compound lend themselves to both biological significance and synthetic intrigue. Here are some compelling facts:

  • Complex Structure: The designation of this compound highlights its intricate molecular architecture with a tricyclic framework, which is essential in influencing its reactivity and potential applications.
  • Bioactivity: Compounds that incorporate both indole and their derivatives often exhibit a wide range of biological activities, including anti-inflammatory and antitumor properties. This makes them of interest in pharmaceuticals.
  • Research Applications: The unique azatricyclo structure opens pathways for novel research into drug development, especially in the fields of neurochemistry and oncology, where many potent compounds owe their effectiveness to complex cyclic structures.
  • Synthesis Challenges: The synthesis of such a compound may pose challenges due to steric hindrances and the need for specific reaction conditions, which challenges chemists to develop innovative methodologies.
  • Interdisciplinary Interest: This compound attracts attention not only in synthetic organic chemistry but also in pharmacology, biochemistry, and molecular biology, underscoring the interdisciplinary nature of modern chemical research.

In conclusion, (10-oxo-8-azatricyclo[5.3.1.03,8]undecan-5-yl) 1H-indole-3-carboxylate exemplifies the marvels of chemical diversity and the potential that lies in even the most intricate structures. It reflects how chemistry enables us to uncover the complexities of nature and develop solutions that could significantly impact human health.

Synonyms
Anzemet
CHEBI:4682
139014-62-3
Dolasetron (INN)
(2alpha,6alpha,8alpha,9ass)-octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl-1Hindole-3-carboxylate monomethanesulfonate, monohydrate
3-oxooctahydro-2h-2,6-methanoquinolizin-8-yl 1h-indole-3-carboxylate
SCHEMBL42065
CHEMBL124754
SCHEMBL14014817
DTXSID20861231
(3R)-10-oxo-8-azatricyclo[5.3.1.03,8]undec-5-yl 1H-indole-3-carboxylate
NS00005447
C07866
D07867
(10-oxo-8-azatricyclo[5.3.1.03,8]undecan-5-yl) 1H-indole-3-carboxylate
1H-Indole-3-carboxylic acid 10-oxo-8-aza-tricyclo[5.3.1.03,8]undec-5-yl ester