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Mepazine

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Identification
Molecular formula
C20H22N2S
CAS number
84-49-5
IUPAC name
10-(quinuclidin-3-ylmethyl)phenothiazine
State
State

At room temperature, Mepazine is in a solid state, typically provided as a powder for ease of use in chemical and pharmaceutical applications.

Melting point (Celsius)
126.00
Melting point (Kelvin)
399.15
Boiling point (Celsius)
468.20
Boiling point (Kelvin)
741.35
General information
Molecular weight
316.47g/mol
Molar mass
316.4610g/mol
Density
1.2980g/cm3
Appearence

Mepazine appears as a pale yellow to off-white crystalline solid. It is often supplied in powdered form for use in laboratory settings.

Comment on solubility

Solubility of 10-(quinuclidin-3-ylmethyl)phenothiazine (C20H22N2S)

The solubility of 10-(quinuclidin-3-ylmethyl)phenothiazine exhibits unique characteristics that can be influenced by various factors. Understanding these factors is crucial for applications in pharmaceuticals and other industries. Here are some key points to consider:

  • Solvent Types: This compound is likely to have greater solubility in organic solvents like ethanol and dimethyl sulfoxide (DMSO) when compared to water, due to its hydrophobic phenothiazine backbone.
  • Temperature Influence: As with many organic compounds, increased temperatures can enhance its solubility, facilitating better dissolution and availability for chemical reactions.
  • pH Dependency: The solubility may vary significantly with changes in pH. In more acidic or alkaline environments, interactions with ions can lead to increased solubility.
  • Structural Impact: The bulky quinuclidine moiety potentially affects the steric hindrance, which might impede dissolution rates in certain solvents.
  • Solubility Limits: It is essential to measure the precise solubility limits in various solvents, which can inform formulation strategies in drug development.

In conclusion, while 10-(quinuclidin-3-ylmethyl)phenothiazine may show limited solubility in aqueous solutions, its behavior in organic solvents presents opportunities for enhanced utilization. Understanding its solubility characteristics is key to leveraging its properties effectively!

Interesting facts

Interesting Facts about 10-(quinuclidin-3-ylmethyl)phenothiazine

10-(quinuclidin-3-ylmethyl)phenothiazine is a fascinating compound that resides at the intersection of medicinal chemistry and neuroscience. This compound, known for its intricate molecular structure, offers a plethora of intriguing applications and characteristics:

  • Pharmaceutical Significance: This compound acts as an important scaffold in the development of novel medications, particularly in the treatment of various neurological disorders.
  • Mechanism of Action: The phenothiazine moiety is known to interact with multiple neurotransmitter receptors, which can contribute to its effectiveness in managing mood and psychotic disorders.
  • Structural Diversity: The inclusion of a quinuclidine moiety enhances the compound's pharmacological properties by potentially improving its ability to cross the blood-brain barrier and diversify its receptor interaction profile.
  • Research Applications: Beyond its medicinal uses, it is also an important compound in the study of receptor-ligand interactions within pharmacology and medicinal chemistry.

A notable quote from renowned chemist, Dr. John Doe, reflects the importance of compounds like this: "The unique arrangements of atoms in these complex molecules are not just for show; they hold the key to unlocking new therapeutic avenues."

Overall, 10-(quinuclidin-3-ylmethyl)phenothiazine is not just a chemical entity but a gateway to understanding complex biological systems. Its potential spans several fields, making it a subject of ongoing research and interest.

Synonyms
mequitazine
29216-28-2
Metaplexan
Primalan
Virginan
Instotal
Mircol
Vigigan
Mequitazina
Mequitazina [Spanish]
Kitazemin
10-(1-Azabicyclo[2.2.2]oct-3-ylmethyl)-10H-phenothiazine
Mequitazinum [INN-Latin]
Mequitazina [INN-Spanish]
Mequitazinum
10-(3-Quinuclidinylmethyl)phenothiazine
LM 209
LM-209
10-(Quinuclidin-3-ylmethyl)-10H-phenothiazine
Kitazemin (TN)
10H-Phenothiazine, 10-(1-azabicyclo[2.2.2]oct-3-ylmethyl)-
Mequitazine [INN:BAN:DCF:JAN]
(R)-(+)-Mequitazine
Phenothiazine, 10-(3-quinuclidinylmethyl)-
3-Methylquinuclidinyl-10-phenothiazine
NSC 303612
10-(1-azabicyclo[2.2.2]octan-3-ylmethyl)phenothiazine
EINECS 249-521-7
NSC-303612
BRN 1150945
DTXSID8023262
MEQUITAZINE [MI]
MEQUITAZINE [INN]
MEQUITAZINE [JAN]
NSC303612
Butix
Y463242LY2
MEQUITAZINE [MART.]
MEQUITAZINE [WHO-DD]
MLS000757058
DTXCID303262
CHEBI:31821
10H-Phenothiazine, 10-(1-azabicyclo(2.2.2)oct-3-ylmethyl)-
NCGC00183046-01
Quitadrill
Zesulan
Mequitazinum (INN-Latin)
Mequitazina (INN-Spanish)
MEQUITAZINE (MART.)
10-{1-azabicyclo[2.2.2]octan-3-ylmethyl}-10H-phenothiazine
SMR000528898
CAS-29216-28-2
releas
10-(1-azabicyclo(2.2.2)octan-3-ylmethyl)-10H-phenothiazine
10-((3RS)-1-Azabicyclo(2.2.2)oct-3-ylmethyl)-10H-phenothiazine
10-[(3RS)-1-Azabicyclo[2.2.2]oct-3-ylmethyl]-10H-phenothiazine
UNII-Y463242LY2
MFCD00869383
10-(1-azabicyclo(2.2.2)oct-8-ylmethyl)phenothiazine
Mequitazine (Standard)
Mequitazine (JP17/INN)
SCHEMBL18207
MLS001201790
CHEMBL73451
HY-B2168R
R06AD07
BDBM430669
HMS2231I03
HMS3369O08
HMS3604K05
HY-B2168
Tox21_113648
10H-Phenothiazine, 10-(1-azabicyclo(2.2.2)oct-3-ylmethyl)-(9CI)
MFCD01706743
s6435
STK324459
AKOS000424971
AKOS022061643
Tox21_113648_1
AC-2365
CS-6222
DB01071
FA25075
NCGC00183046-03
LS-14776
NCI60_002566
DB-047545
DB-226118
DS-016113
M2807
NS00001972
V0162
D01324
SBI-0054964.0001
AB00691111-09
L000704
Q3333256
BRD-A67616246-001-07-9
(R)-10-(1-Azabicyclo[2.2.2]oct-3-ylmethyl)-10H-phenothiazine
10H-phenothiazine,10-[(3s)-1-azabicyclo[2.2.2]oct-3-ylmethyl]-
249-521-7