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Estrone sulfate

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Identification
Molecular formula
C18H22O5S
CAS number
438-67-5
IUPAC name
(10,13-dimethyl-17-oxo-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-yl) hydrogen sulfate
State
State

Estrone sulfate is typically found as a solid at room temperature. It is used in various pharmaceutical applications, largely related to hormone therapy.

Melting point (Celsius)
248.00
Melting point (Kelvin)
521.00
Boiling point (Celsius)
670.00
Boiling point (Kelvin)
943.00
General information
Molecular weight
350.43g/mol
Molar mass
350.4740g/mol
Density
1.3600g/cm3
Appearence

Estrone sulfate typically appears as a white to off-white powder. It is usually odorless and stable under normal conditions. It may also be found in a crystalline form.

Comment on solubility

Solubility of (10,13-dimethyl-17-oxo-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-yl) hydrogen sulfate

The solubility of the compound (10,13-dimethyl-17-oxo-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-yl) hydrogen sulfate (C18H22O5S) can be influenced by various factors. Understanding its solubility characteristics is essential for both its practical applications and theoretical studies.

Key Factors Influencing Solubility:

  • Polarity: This compound contains a hydrogen sulfate group, which is typically polar and can lead to increased solubility in polar solvents like water.
  • Hydrogen Bonding: The presence of hydroxyl and sulfate functional groups can facilitate hydrogen bonding, enhancing solubility in polar environments.
  • Molecular Structure: The complex multi-ring structure could affect the overall interaction with solvents, possibly leading to lower solubility in non-polar solvents due to hydrophobic interactions.
  • Temperature: Solubility often varies with temperature, so studying the compound at different temperatures may provide insight into its behavior in solution.

In summary, while the compound's hydrogen sulfate moiety suggests a degree of aqueous solubility, the extensive hydrophobic regions resulting from the multi-cyclic structure may limit solubility in organic solvents. It is essential to experimentally assess solubility in various solvents to obtain a clearer understanding of its solubility profile.

Interesting facts

Interesting Facts about (10,13-dimethyl-17-oxo-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-yl) hydrogen sulfate

This complex organic compound belongs to a fascinating class of chemicals known as steroids, widely recognized for their significant roles in biology. Here are some intriguing aspects of this compound:

  • Biological Importance: Steroids, including derivatives of this compound, are crucial in a variety of biological processes. They regulate metabolism, immune responses, and even play key roles in the development and maintenance of sexual characteristics.
  • Hydrogen Sulfate Group: The presence of a hydrogen sulfate group adds an interesting twist to the compound's reactivity. This functional group can often contribute to the compound's biological activity and solubility in various solvents.
  • Synthetic and Natural Sources: Many steroids, including those similar to this one, can be synthesized in the lab or extracted from natural sources, such as plants or animal tissues. This dual-source capability makes them versatile in applications within pharmaceuticals.
  • Applications: With steroids being integral to medicinal chemistry, compounds like this one often find use in therapies aimed at treating hormonal imbalances, inflammatory conditions, or acting as anabolic steroids for muscle growth and development.
  • Complex Structure: The intricate structure of this compound, which involves multiple functional groups and a fused ring system, makes it a subject of interest for synthetic chemists attempting to create more effective derivatives.

In conclusion, the study of (10,13-dimethyl-17-oxo-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-yl) hydrogen sulfate not only illuminates the intricate relationships between structure and function in organic chemistry but also emphasizes the enduring relevance of steroids in both natural and synthetic realms. As we investigate these compounds further, we unveil their potential to address some of today's pressing health challenges.

Synonyms
17-Oxoandrost-5-en-3-yl hydrogen sulfate
NCIOpen2_008937
CHEMBL141691
SCHEMBL12871723
DTXSID50859525
CZWCKYRVOZZJNM-UHFFFAOYSA-N
[(2R,5S,15S)-2,15-dimethyl-14-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-yl]oxidanesulfonic acid
PD074434
17-Oxoandrost-5-en-3-yl hydrogen sulfate #