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Estradiol

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Identification
Molecular formula
C18H24O2
CAS number
50-28-2
IUPAC name
10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol
State
State

Estradiol is in a solid state at room temperature.

Melting point (Celsius)
173.00
Melting point (Kelvin)
446.15
Boiling point (Celsius)
563.00
Boiling point (Kelvin)
836.15
General information
Molecular weight
272.38g/mol
Molar mass
272.3830g/mol
Density
1.1659g/cm3
Appearence

Estradiol appears as a white to off-white crystalline powder. It is practically odorless.

Comment on solubility

Solubility of 10,13-Dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol

The solubility of complex organic compounds like 10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol can be quite nuanced and depend on a variety of factors:

  • Polarity: This compound likely exhibits relatively low polarity due to its hydrocarbon backbone, which suggests that it may be more soluble in non-polar solvents.
  • Solvent Interaction: It may dissolve better in organic solvents like hexane or chloroform than in polar solvents like water.
  • Temperature: As with many organic compounds, solubility can increase with temperature, potentially allowing for better dissolution in organic solvents when heated.
  • Functional Groups: The presence of hydroxyl (-OH) groups may impart some degree of hydrophilicity, allowing for limited solubility in polar solvents; however, this effect might be outweighed by the larger hydrophobic structure.

Given these factors, it might be said that 10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol will demonstrate:

  1. Greater solubility in non-polar organic solvents
  2. Limited solubility in polar solvents

In summary, the solubility profile of this compound underscores the importance of considering both molecular structure and solvent characteristics, ultimately influencing its usability in various chemical applications.

Interesting facts

Interesting Facts About 10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol

This fascinating compound, often categorized as a steroid, holds remarkable significance in both biological and industrial contexts. Below are several intriguing points that highlight its importance:

  • Biological Relevance: The compound is known for its resemblance to steroids, which are crucial in a multitude of physiological processes such as hormone regulation, cell signaling, and metabolism.
  • Natural Occurrence: It has been found in various natural sources, prompting researchers to explore its ecological functions and potential health benefits.
  • Structure and Stability: Its unique polycyclic structure allows for intriguing stereochemistry, contributing to its stability and reactivity under specific conditions.
  • Synthetic Applications: The compound has drawn interest in synthetic organic chemistry, as it serves as a valuable precursor for the synthesis of more complex molecules.
  • Research Applications: Due to its structural characteristics, this compound can serve as a model for studying interactions in biological systems, which is essential for drug development and pharmaceutical chemistry.

Due to its unique properties, 10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol continues to be a subject of extensive research while inspiring many young chemists to delve deeper into the realms of organic and medicinal chemistry.

Synonyms
10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol
Androstane-3.alpha.,17.beta.-diol
Etiocholane-3.alpha.,17.beta.-diol
Androstane-3,17-diol #
5.alpha.-Androstane-3.alpha.,17.beta.-androstanediol
5?-Androstan-3?,17?-diol
3.alpha.,17.beta.-Dihydroxy-5.alpha.-androstane
5ALPHA-ANDROSTAN-3ALPHA,17BETA-DIOL-16,16,17-D3
Oprea1_827742
SCHEMBL12657941
NSC9899
CBMYJHIOYJEBSB-UHFFFAOYSA-N
ABA12676
EDA03733
FAA85610
FAA85611
UAA76769
(3?,5?)-Androstane-3,17-diol
5beta-androstane-3beta,17alpha-diol
AKOS004903575
PD015599
Androstane-3, (3.alpha.,5.alpha.,17.beta.)-
(17S)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol